Antileishmanial Compounds from<i>Cordia fragrantissima</i> Collected in Burma (Myanmar)

Mori, Kentaro; Kawano, Marii; Fuchino, Hiroyuki; Ooi, Takashi; Satake, Motoyoshi; Agatsuma, Yutaka; Kusumi, Takenori; Sekita, Setsuko

doi:10.1021/np070211i

Cited by 29 publications

(31 citation statements)

References 19 publications

(36 reference statements)

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“…[58,59] Later, six new hydroquinones, namely alliodorol (2), allioquinol C (3), cordiachromen A (4), cordallinol (9), Cordiaquinol C (11) and cordiol A (10), were reported to be found in the acetone extract of heartwood of C. alliodora. [60] Ioset et al [61] isolated 2-(2Z)-(3-hydroxy-3,7-dimethylocta-2,6-dienyl)-1,4-benzenediol (16) from the root bark.…”

Section: Hydroquinonementioning

confidence: 99%

“…As per structural characteristics, they are classified into four classes: (1) oleanane type isolated from C. alliodora, C. cylindrostachya, C. piauhiensis, C. latifolia and C. multispicata [74][75][76][77][78] ; (2) lupane type identified from C. obliqua and C. gilletii [79][80][81] ; (3) ursane type reported from C. retusa, C. obliqua, C. rothii and C. multispicata [80,[82][83][84][85] ; and (4) dammarane type found in C. spinescens, C. multispicata and C. verbenacea. [86][87][88] [58] C. fragrantissima [59] Heartwood Timber Alliodorol (2) C. alliodora [58] Heartwood Allioquinol C (3) C. alliodora [58] Heartwood Cordiachrome A (4) C. alliodora [58] Heartwood Cordiachrome A (5) C. fragrantissima [59] Timber Cordiachrome B (6) C. fragrantissima [59] Timber Cordiachrome C (7)…”

Section: Triterpenoidsmentioning

confidence: 99%

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Traditional uses, phytochemistry and pharmacology of the medicinal species of the genusCordia(Boraginaceae)

Oza

Kulkarni

2017

Journal of Pharmacy and Pharmacology

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Objectives Cordia (family Boraginaceae) is a genus of deciduous flowering trees or shrubs comprising more than 300 species distributed widely in the tropical regions. The aim of this review was to provide exhaustive scientific information on traditional uses, phytochemistry and pharmacological activities of the 36 important species with medicinal value from the genus Cordia, to divulge prospects for further research on its therapeutic potential. Key findings Leaves, fruit, bark and seed of a majority of the species were found to possess abundant ethnomedicinal value, but leaves were found to be used most frequently to treat many ailments such as respiratory disorders, stomach pain, wound, inflammation, myalgia, cough, dysentery and diarrhoea. The phytochemical investigation of 36 species resulted in isolation of 293 chemical constituents from various chemical classes. The crude extracts, fractions, essential oils and pure compounds isolated from various Cordia species were reported to have a varied range of pharmacological activities. Summary Many of the traditional uses of the genus Cordia were supported by the results obtained from pharmacological studies performed using various extracts or pure compounds. More attention should be given to the biological evaluation using pure phytochemicals and to identify the mechanism of actions and exploring this genus for new drug discovery.

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Section: Hydroquinonementioning

confidence: 99%

Section: Triterpenoidsmentioning

confidence: 99%

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genusCordia(Boraginaceae)

Oza

Kulkarni

2017

Journal of Pharmacy and Pharmacology

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“…[5][6][7][8][9][10] These quinoid compounds, known as cordiaquinones, could be considered as chemotaxinomical markers for the Cordia genus. Nevertheless, the occurrence in their producing plants is limited to the roots and rarely to the trunk wood.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic cordiaquinones from the roots of Cordia polycephala

Freitas¹,

Maia²,

Silveira³

et al. 2012

J. Braz. Chem. Soc.

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A investigação química das raízes de Cordia polycephala resultou no isolamento de duas novas naftoquinonas terpenoídicas, 6-[10-(12,12-dimetil-13α-(22-metil-21-butenoilóxi -[10-(12,12-dimetil-13α-(tigloilóxi)-16-metenilciclohexil)etil]-naftaleno-1,4-diona, designadas de cordiaquinonas N (1) e O (2), respectivamente. As cordiaquinonas já conhecidas, B (3), L (4) e E (5), foram também isoladas. Suas estruturas foram elucidadas após detalhada análise dos dados de RMN 1 H e 13 C (1D e 2D) e EMAR (espectrometria de massas de alta resolução). Todas as cordiaquinonas (1-5) foram avaliadas contra quatro linhagens de células cancerígenas: HCT-8 (colo), HL-60 (leucemia), MDA-MB-435 (melanoma) e SF295 (glioblastoma), mostrando IC 50 na faixa de 1,2 a 11,1 mmol L -1 . As novas cordiaquinonas 1 e 2 foram as mais ativas contra todas as linhagens de câncer, enquanto 3 foi mais seletiva para células leucêmicas (IC 50 2,2 μmol L -1 ).The chemical investigation of roots of Cordia polycephala resulted in the isolation of two new terpenoid naphtoquinones, 6-[10-(12,12-dimethyl-13α-(22-methyl-21-butenoyloxy)-16-methenylcyclohexyl)ethyl]-naphtalene-1,4-dione and (6-[10-(12,12-dimethyl-13α-(tigloyloxy)-16-methenylcyclohexyl)ethyl]-naphtalene-1,4-dione, named as cordiaquinone N (1) and O (2), respectively. The known cordiaquinones B (3), L (4) and E (5) were also isolated. Their structures were elucidated after detailed 1D and 2D NMR and high resolution electrospray ionization mass spectrometry (HRESIMS) data analysis. All cordiaquinones (1-5) were evaluated against four human cancer cell lines: HCT-8 (colon), HL-60 (leukemia), MDA-MB-435 (melanoma) and SF295 (glioblastoma), showing IC 50 values in the range of 1.2 to 11.1 mmol L -1 . The new cordiaquinones 1 and 2 were the most active against all cancer cell lines, while compound 3 was selective to leukemia HL-60 cells (IC 50 2.2 mmol L -1 ).

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“…We have already reported several leishmanicidal constituents of medicinal plants in tropical and subtropical regions (Peru, Myanmar, Bolivia, Pakistan, etc.). [7][8][9][10][11] In the first screening of hundreds of Peruvian medicinal plant extracts for leishmanicidal activity, we found that the extract of Bocconia pearcei fruit exhibited potent activity.…”

mentioning

confidence: 99%

In Vitro Leishmanicidal Activity of Benzophenanthridine Alkaloids from Bocconia pearcei and Related Compounds

Fuchino

Kawano

Mori‐Yasumoto

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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Antileishmanial Compounds fromCordia fragrantissima Collected in Burma (Myanmar)

Cited by 29 publications

References 19 publications

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genusCordia(Boraginaceae)

Traditional uses, phytochemistry and pharmacology of the medicinal species of the genusCordia(Boraginaceae)

Cytotoxic cordiaquinones from the roots of Cordia polycephala

In Vitro Leishmanicidal Activity of Benzophenanthridine Alkaloids from Bocconia pearcei and Related Compounds

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