Antileishmanial activity of indole alkaloids from Aspidosperma ramiflorum

Anti-promastigote Activity of the Amazon Plants

“…Various alkaloids presented anti-leishmanial activity [14][15][16]. In the present study we selected two species of this family, but any alkaloid was detected or isolated.…”

Crystal structure of 3-amino-8-methoxy-1-(4-methoxy phenyl)-1H-benzo[f]chromene-2-carbonitrile, C22H18N2O3

“…Literature reveals that chromenes and benzochromenes are an important chemical synthon, associated with a broad range of pharmacological activities such as antimicrobial [2][3][4][5], anticancer agent [6] hypolipidemic [7], antioxidant [8,9], analgesic [10], antileishmanial [11,12], vascular-disrupting activity [13], estrogenic anticoagulant and antispasmolytic [14], blood platelet antiaggregating [15] effects and activities. As part of our programmed aim to develop new methodologies for the preparation of 1H-benzo[f ]chromene derivatives [16][17][18], we have synthesized the title compound under microwave irradiation conditions.…”

Use of Associated Chromatographic Techniques in Bio-Monitored Isolation of Bioactive Monoterpenoid Indole Alkaloids from Aspidosperma ramiflorum

“…After that, Oliveira 1999 isolated beyond these compounds the 16-(E)-isositrikine (5), all them from stem barks (Figure 1). The basic crude extract from stem barks of A. ramiflorum showed a good antileishmanial activity (Ferreira et al, 2004), which we attributed to the presence of indole alkaloids, and soon after, we described the fractionation, purification and isolation of alkaloids responsible www.intechopen.com for the activity against Leishmania (L.) amazonensis (Tanaka et al, 2007). Our results revealed that dimeric corynanthe alkaloids Ramiflorines A (1) and B (2) were responsible for the activity against promastigote forms of L. amazonensis with significant activity (LD 50 values of 16.3 ± 1.6 µg/ml and 4.9 ± 0.9 µg/ml, respectively).…”