Antileishmanial Activity ofHandroanthus serratifolius(Vahl) S. Grose (Bignoniaceae)

Costa, Erica Vanessa Souza; Brígido, Heliton Patrick Cordovil; Silva, João Victor da Silva e; Coelho–Ferreira, Márlia; Brandão, Geraldo Célio; Dolabela, Maria Fâni

doi:10.1155/2017/8074275

Cited by 19 publications

(14 citation statements)

References 22 publications

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“…Modulatory effect was not verified for BA indicating that the modulatory effect showed by DCMF could be attributed to their minor components or that it results of a synergy between BA and their minor constituents. The marked action of DCMF when compared with BA is possibly due to its lipophilic characteristics, where other compounds might act as a coadjuvant probably forming BA-conjugates in order to better interact with the cell membrane (Costa et al 2017). The advantage of BA-conjugated compounds in inducing a higher cytotoxic activity involving apoptosis associated with loss of mitochondrial membrane potential and increase in intracellular free Ca 2+ have been reported in eukaryotic cells (Xu et al 2017).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of Mimosa caesalpiniifolia Benth and its interaction with antibiotics against Staphylococcus aureus strains overexpressing efflux pump genes

Silva

Monção

Araújo

et al. 2019

Lett Appl Microbiol

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This study aimed to evaluate the antimicrobial activity of the dichloromethane fraction (DCMF) from the stem bark of Mimosa caesalpiniifolia and its effect on the activity of conventional antibiotics against Staphylococcus aureus strains overexpressing specific efflux pump genes. DCMF showed activity against S. aureus, Staphylococcus epidermidis and Candida albicans. Addition of DCMF at subinhibitory concentrations to the growth media enhanced the activity of norfloxacin, ciprofloxacin and ethidium bromide against S. aureus strains overexpressing norA suggesting the presence of efflux pump inhibitors in its composition. Similar results were verified for tetracycline against S. aureus overexpressing tetK, as well as, for ethidium bromide against S. aureus overexpressing qacC. These results indicate that M. caesalpiniifolia is a source of molecules able to modulate the fluoroquinolone‐ and tetracycline‐resistance in S. aureus probably by inhibition of NorA, TetK and QacC respectively. Significance and Impact of the Study Drug resistance is a common problem in patients with infectious diseases. Dichloromethane fraction from the stem bark of Mimosa caesalpiniifolia showed antimicrobial activity against Gram‐positive bacterium Staphylococcus aureus and against Candida albicans, but did not show activity against Gram‐negative specie Escherichia coli. Moreover, this fraction was able to potentiate the action of norfloxacin, ciprofloxacin and tetracycline against S. aureus strains overexpressing different efflux pump genes. Thus, Mimosa caesalpiniifolia is a source of efflux pump inhibitors which could be used in combination with fluoroquinolones or tetracycline in the treatment of infectious diseases caused by S. aureus strains overexpressing efflux pump genes.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial activity of Mimosa caesalpiniifolia Benth and its interaction with antibiotics against Staphylococcus aureus strains overexpressing efflux pump genes

Silva

Monção

Araújo

et al. 2019

Lett Appl Microbiol

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“…Based on the results of IC50 values in Table 3, extracts that have cytotoxic activity against T47D cells are extracts of leaves, stems, and roots. An extract otherwise has a high cytotoxic activity when the value of IC50 <500 mg / mL and is said to have a weak activity where the IC50 values>500 pg / mL [16]. The IC50 amount of positive control is 208.82 nM.…”

Section: Cytotoxic Test For T47d Cells Cytotoxicitymentioning

confidence: 99%

ANTICANCER ACTIVITIES AND METABOLITE FINGERPRINTING OF UPLC-QToF-MS/MS METHOD FROM Chrysanthemum cinerariifolium (Trev)

Lestari¹,

Irawati²,

Listiyana³

et al. 2019

J. Islamic Pharm.

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Chrysanthemum cinerariifolium (C. cinerariifolium) is an empirically proven medicinal plant that has anticancer activities. This study aimed to profile metabolites, and cytotoxic activity of root, leaf, stem, and root extracts C. cinerariifolium on T47D cells and to determine the correlation of metabolite content with cytotoxic activity. The metabolite profile was carried out using UPLC-QToF-MS / MS, and cytotoxic activity was carried out using the MTT method. The results obtained in the form of a chromatogram were processed with the application Masslynk so that a metabolite profile data obtained. The data is then analyzed statistically using Principal Component Analysis (PCA). The results obtained on metabolite profiling showed that there were differences in metabolite profiles in the roots, stems, leaves, and chrysanthemums. The characteristic compounds in the flower section are D - (-) - Morphine and in the leaf part of genistein and N - [(5-Chloro-1,2,3-thiadiazol-4-yl) methyl] -1- (2-isopropyl-4 -methyl-1,3-thiazol-5-yl) -N-methyl ethanolamine. The major compounds in the roots, stems, and leaves are Orphenadrine with successive percentages of 9.11%, 10.16%, and 3.24%, and the major compounds in the flower section are D - (-) - Morphine with a percentage of 10, 86%. Furthermore, the results of the cytotoxic activity test showed differences in anticancer cytotoxic activity in the parts of the flower, leaf, stem, and root of C. cinerariifolium. Besides, there is a relationship between the metabolite content and anticancer cytotoxic activity of each part of C. cinerariifolium. The higher the level of orphenadrine compounds in the plant, the higher the potential for anticancer. Keywords: C. cinerariifolium, UPLC-QToF-MS/MS, T47D cells.

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“…La madera de la especie tiene importancia económica principalmente en la construcción civil y con fines tecnológicos, como los mangos de herramientas y los muebles (Oliveira et al 2019). La corteza del tronco tiene propiedades farmacológicas, utilizándose en la medicina tradicional para el tratamiento de inflamaciones generales, enfermedades respiratorias, así como metabolitos secundarios con actividades antipalúdicas, antitumorales y antiparasitarias (Costa et al 2017). Se cultiva ampliamente en las zonas urbanas para la ornamentación y puede utilizarse en la recuperación de zonas degradadas y en la reforestación, adaptándose a los suelos secos de baja fertilidad (Vieira y Weber 2017).…”

Section: Introductionunclassified

Factores abióticos sobre aspectos ecofisiológicos de Handroanthus impetiginosus y Handroanthus serratifolius

Ribeiro

Coêlho

2021

Bosque (Valdivia)

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The objective of this research was to evaluate the influence of abiotic factors on the ecophysiological aspects of Handroanthus impetiginosus and Handroanthus serratifolius throughout the day, as well as to indicate the ideal time for ecophysiological evaluations. The design was entirely randomized, with ten treatments and six repetitions for each species. The treatments used were ten evaluation times throughout the day (8h-17h) with an interval of one hour between them. Climatic variables evaluated were internal and external temperature, relative humidity of the internal and external air of the greenhouse and the photosynthetically active radiation of the environment. Ecophysiological aspects evaluated were: net CO 2 assimilation, stomatal conductance, transpiration, internal CO 2 concentration, vapor pressure deficit, instantaneous water use efficiency, intrinsic water use efficiency and instantaneous carboxylation efficiency. The canonical correlation analysis and principle component analysis were used to verify associations between climatic and ecophysiological variables. In both species, climatic variables were correlated with ecophysiological variables, with higher association between photosynthetically active radiation, internal and external temperature of environment, with the rate of net CO 2 assimilation, stomatal conductance, transpiration, instantaneous carboxylation efficiency and vapor pressure deficit. The influence of climatic factors on the ecophysiological aspects of H. impetiginosus and H. serratifolius was verified. In both species, the ideal time of day for measuring ecophysiological variables is between 11h and 13h.

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Antileishmanial Activity ofHandroanthus serratifolius(Vahl) S. Grose (Bignoniaceae)

Cited by 19 publications

References 22 publications

Antimicrobial activity of Mimosa caesalpiniifolia Benth and its interaction with antibiotics against Staphylococcus aureus strains overexpressing efflux pump genes

Antimicrobial activity of Mimosa caesalpiniifolia Benth and its interaction with antibiotics against Staphylococcus aureus strains overexpressing efflux pump genes

ANTICANCER ACTIVITIES AND METABOLITE FINGERPRINTING OF UPLC-QToF-MS/MS METHOD FROM Chrysanthemum cinerariifolium (Trev)

Factores abióticos sobre aspectos ecofisiológicos de Handroanthus impetiginosus y Handroanthus serratifolius

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