2013
DOI: 10.1590/s0074-02762013000100010
|View full text |Cite
|
Sign up to set email alerts
|

Antileishmanial activity of diterpene acids in copaiba oil

Abstract: Leishmaniasis is a neglected tropical disease. According to the World Health Organization, there are approximately 1.5-two million new cases of cutaneous leishmaniasis each year worldwide. Chemotherapy against leishmaniasis is based on pentavalent antimonials, which were developed more than a century ago. The goals of this study were to investigate the antileishmanial activity of diterpene acids in copaiba oil, as well as some possible targets of their action against Leishmania amazonensis. Methyl copalate and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
37
0
3

Year Published

2013
2013
2022
2022

Publication Types

Select...
9
1

Relationship

1
9

Authors

Journals

citations
Cited by 65 publications
(40 citation statements)
references
References 18 publications
0
37
0
3
Order By: Relevance
“…O seuà leoà e aà e ele teà pa aà aà u aà deà feridas, porque nem mesmo restam vestígios deà i at izes ,à dizà eleà p gi aà .à Ga ielà Soares de Sousa 60 oà o side avaà u à leoà sa tíssi o à ta à usadoà pa aà f ialdades,à dores de barriga e po tadasà deà f io à p gi aà 164). Para Gândavo 49 ,antiinflamatória [261][262][263][264][265][266][267] , antileishmania [268][269][270][271] , na endometriose 272 , na urolitíase 273 , na acne 274 , na psoríase 275 , no controle do mosquito Aedes aegypti [276][277][278] , no controle de ácaros 279 e em infecções ginecológicas. 280 O óleo da copaíba também reduz os níveis séricos de ureia e creatinina em ratos submetidos à síndrome de isquemia e reperfusão.…”
Section: Graças a Essas Duas Instituiçõesunclassified
“…O seuà leoà e aà e ele teà pa aà aà u aà deà feridas, porque nem mesmo restam vestígios deà i at izes ,à dizà eleà p gi aà .à Ga ielà Soares de Sousa 60 oà o side avaà u à leoà sa tíssi o à ta à usadoà pa aà f ialdades,à dores de barriga e po tadasà deà f io à p gi aà 164). Para Gândavo 49 ,antiinflamatória [261][262][263][264][265][266][267] , antileishmania [268][269][270][271] , na endometriose 272 , na urolitíase 273 , na acne 274 , na psoríase 275 , no controle do mosquito Aedes aegypti [276][277][278] , no controle de ácaros 279 e em infecções ginecológicas. 280 O óleo da copaíba também reduz os níveis séricos de ureia e creatinina em ratos submetidos à síndrome de isquemia e reperfusão.…”
Section: Graças a Essas Duas Instituiçõesunclassified
“…Furthermore, different classes of terpenes have been demonstrated desirable synergistic effects when combined, since drug combination may improve the parasitic activity with lower dosage of these substances, in addition to reducing their undesirable toxic effects. [11][12][13][14][15][16][17] The search for synergic compounds can improve the efficiency of the treatment, reduce their toxicities on mammalian cells and diminish the selection of resistant mutations. 12,[18][19][20] Alternative strategies have been designed to identify candidates among the already available drugs in the market that could be used in combination to provide synergic effects and improve the chemotherapy efficacy.…”
Section: Introductionmentioning
confidence: 99%
“…This turns them an interesting source of natural products to be isolated and assayed against different pathological agents. [16][17][18] Terpenoids are one of the largest classes of natural products, 12 and some of them are widely used as starting materials in natural products synthesis. 16 Some diterpenes displayed a remarkable antitubercular activity against M. tuberculosis, despite the fact that only a limited number of them were assayed against this pathogenic agent.…”
Section: Introductionmentioning
confidence: 99%