Antiirritant Properties of Polyols and Amino Acids

Korponyai, Csilla; Kovács, Réka; Erős, Gábor; Dikstein, S.; Kemény, Lajos

doi:10.2310/6620.2011.10082

Cited by 13 publications

(10 citation statements)

References 1 publication

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“…In addition to glycerol, xylitol has been proven to be an effective anti‐irritant when applied together with 0.1% of SLS . In this study, we provide evidence that xylitol can ameliorate a more serious inflammation, as well, and can exert its beneficial effect at a lower concentration compared to glycerol.…”

Section: Discussionmentioning

confidence: 63%

“…In addition to glycerol, xylitol has been proven to be an effective anti-irritant when applied together with 0.1% of SLS. 8 In this study, we provide evidence that xylitol can ameliorate a more serious inflammation, as well, and can exert its beneficial effect at a lower concentration compared to glycerol. Although it is difficult to predict the in vivo activity of polyols on the basis of their chemical structure, 21 efficacy of xylitol may originate in its water binding capacity.…”

Section: Effects Of Polyols In Irritant Contact Dermatitismentioning

confidence: 67%

“…Recent studies indicated that xylitol can be utilized as humectant and moisturizer, as well . In our previous study, we have shown that both glycerol and xylitol suppresses the 0.1% sodium lauryl sulphate (SLS)‐induced acute skin irritation . However, it is not clear whether these polyols are able to provide protection against a more serious irritation.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 In our previous study, we have shown that both glycerol and xylitol suppresses the 0.1% sodium lauryl sulphate (SLS)-induced acute skin irritation. 8 However, it is not clear whether these polyols are able to provide protection against a more serious irritation. Despite their similar chemical structure, in vitro examinations suggest that glycerol and xylitol evoke different gene expression changes in keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐irritant and anti‐inflammatory effects of glycerol and xylitol in sodium lauryl sulphate‐induced acute irritation

Szél

Polyánka

Szabó

et al. 2015

Acad Dermatol Venereol

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Background Glycerol is known to possess anti‐irritant and hydrating properties and previous studies suggested that xylitol may also have similar effects. Objective Our aim was to study whether different concentrations of these polyols restore skin barrier function and soothe inflammation in sodium lauryl sulphate (SLS)‐induced acute irritation. Methods The experiments were performed on male SKH‐1 hairless mice. The skin of the dorsal region was exposed to SLS (5%) for 3 h alone or together with 5% or 10% of glycerol respectively. Further two groups received xylitol solutions (8.26% and 16.52% respectively) using the same osmolarities, which were equivalent to those of the glycerol treatments. The control group was treated with purified water. Transepidermal water loss (TEWL) and skin hydration were determined. Microcirculatory parameters of inflammation were observed by means of intravital videomicroscopy (IVM). Furthermore, accumulation of neutrophil granulocytes and lymphocytes, the expression of inflammatory cytokines and SLS penetration were assessed, as well. Results Treatment with the 10% of glycerol and both concentrations of xylitol inhibited the SLS‐induced elevation of TEWL and moderated the irritant‐induced increase in dermal blood flow and in the number of leucocyte‐endothelial interactions. All concentrations of the applied polyols improved hydration and prevented the accumulation of lymphocytes near the treatment site. At the mRNA level, neither glycerol nor xylitol influenced the expression of interleukin‐1 alpha. However, expression of interleukin‐1 beta was significantly decreased by the 10% glycerol treatment, while expression of tumour necrosis factor‐alpha decreased upon the same treatment, as well as in response to xylitol. Higher polyol treatments decreased the SLS penetration to the deeper layers of the stratum corneum. Conclusion Both of the analysed polyols exert considerable anti‐irritant and anti‐inflammatory properties, but the effective concentration of xylitol is lower than that of glycerol.

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Section: Discussionmentioning

confidence: 63%

Section: Effects Of Polyols In Irritant Contact Dermatitismentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti‐irritant and anti‐inflammatory effects of glycerol and xylitol in sodium lauryl sulphate‐induced acute irritation

Szél

Polyánka

Szabó

et al. 2015

Acad Dermatol Venereol

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“…[17,18] Moreover, in a human study, we have recently shown that xylitol (similar to glycerol) markedly suppressed sodium lauryl sulphate-induced transepidermal water loss and exerted antiirritant actions. [19] Interestingly, albeit xylitol containing hydrogel formulations were found to increase skin hydration, [20] xylitol failed to correct the impaired hydration and epidermal barrier of AQP3deficient mice. [7]…”

mentioning

confidence: 99%

Beyond the physico‐chemical barrier: Glycerol and xylitol markedly yet differentially alter gene expression profiles and modify signalling pathways in human epidermal keratinocytes

Páyer

Szabó-Papp

Ambrus

et al. 2018

Experimental Dermatology

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Polyols (e.g. glycerol, xylitol) are implicated as moisturizers of the skin and other epithelial tissues. However, we lack information about their exact cellular mechanisms and their effects on the gene expression profiles. Therefore, in this study, we aimed at investigating the effects of glycerol and xylitol on human epidermal keratinocytes. The polyols (identical osmolarities; xylitol: 0.0045%-0.45%; glycerol: 0.0027%-0.27%) did not alter cellular viability or intracellular calcium concentration. However, they exerted differential effects on the expression of certain genes and signalling pathways. Indeed, both polyols up-regulated the expression of filaggrin, loricrin, involucrin and occludin; yet, xylitol exerted somewhat more profound effects. Moreover, while both polyols stimulated the MAPK pathway, only xylitol induced the activation-dependent translocation of protein kinase Cδ, a key promoter of epidermal differentiation. Finally, in various keratinocyte inflammation models, both polyols (albeit with different efficacies) exerted anti-inflammatory effects. Taken together, these data strongly suggest that glycerol and xylitol differentially modulate expressions of multiple genes and activities of signalling pathways in epidermal keratinocytes. Thus, our findings invite clinical trials to explore the applicability and the impact of a combined glycerol-xylitol therapy in the management of various skin conditions.

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Taurine (2-Aminoethanesulfonic Acid): Useful in Skin Diseases

Badole¹,

Chaudhari²

2012

Bioactive Dietary Factors and Plant Extracts in Dermatology

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Antiirritant Properties of Polyols and Amino Acids

Cited by 13 publications

References 1 publication

Anti‐irritant and anti‐inflammatory effects of glycerol and xylitol in sodium lauryl sulphate‐induced acute irritation

Anti‐irritant and anti‐inflammatory effects of glycerol and xylitol in sodium lauryl sulphate‐induced acute irritation

Beyond the physico‐chemical barrier: Glycerol and xylitol markedly yet differentially alter gene expression profiles and modify signalling pathways in human epidermal keratinocytes

Taurine (2-Aminoethanesulfonic Acid): Useful in Skin Diseases

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