Antiinflammatory drugs

Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials

“…However, PB and OPB are still used in regions where cost governs access. Gastrointestinal distress with OPB is common (∼10%) but avoidable with coated tablets or antacids (44). Less frequent are rash, gastric ulcers, hypersensitivity reactions, Na + retention, hepatitis, renal disorders, leukopenia, agranulocytosis, and aplastic anemia.…”

“…The most serious toxicities are more frequent in the elderly. The incidence of acute bone marrow failure was estimated at less than 1 in 50,000 (45) and at 1 in 66,000 (44). In the setting of drug-resistant TB, the major toxicities of OPB should be considered in the context of the dire prognosis and compared with those of second-line drugs, which averaged 16% in a recent report (46).…”

A Controlled Study of Mefenamic Acid and Sulindac in Osteoarthrosis

“…Despite these limitations, the results were reasonably encouraging both for mefenamic acid and for sulindac. That the former drug should prove virtually as effective as the latter is indeed a little surprising in view of a classification which places mefenamic acid among the analgesics with minor anti-inflammatory properties -such as the propionic acid derivatives -and sulindac in the major anti-inflammatory group -with indomethacin and phenylbutazone (Huskisson, 1977). Our results however tend to confirm those reported by a group of investigators at the Centre for Rheumatic Diseases in Glasgow, who found mefenamic acid an underrated anti-inflammatory agent in the treatment of rheumatoid arthritis (Mavrikakis et al, 1977).…”

Detecting and exploiting the circadian clock in rheumatoid arthritis

“…116 In 1976, a study reported that an evening dose of indomethacin was more effective in controlling the morning symptoms of inflammatory arthropathies than a morning dose. 117 This result is supported by two other studies from the 1980s showing that the same regimen with either indomethacin or flurbiprofen improved the morning symptoms better than a morning or day dose in osteoarthritis and RA, respectively. 118,119 One of the most convincing pieces of evidence for the successful application of chronotherapy was demonstrated through the administration of modifiedrelease prednisone (a GC) before bedtime (10 p.m.) in RA patients.…”