A Controlled Study of Mefenamic Acid and Sulindac in Osteoarthrosis

Mefenamic Acid and Diclofenac Sodium in Osteoarthritis of the Weight Bearing Joints: A Double Blind Comparison

“…Comparisons between mefenamic acid and prednisone, 6 indomethacin, 6 , 7 , 8 flurbiprofen, 6 , 3 ibuprofen 9 , 11 and sulindac 11 , 14 have confirmed earlier results and shown that mefenamic acid is an effective drug in the management of arthritic conditions.…”

Mefenamic acid compared with diclofenac sodium in elderly patients with osteoarthritis

“…Even so, very few trials have been performed of duration longer than four weeks. The trials of Stockman 1 in rheumatoid arthritis and Jaffe 2 and Aylward 3 in osteoarthritis showed that it was as effective as some other non‐steroidal anti‐inflammatory drugs (NSAIDs) with a similar incidence of side‐effects.…”

Mefenamic acid versus ibuprofen in osteoarthritis — a double‐blind cross‐over study

“…In an eight week cross‐over study involving 53 patients with osteoarthritis, mefenamic acid 1500 mg produced better control of passive and night pain than ibuprofen 1200 mg. Ibuprofen produced a slightly better control of active pain and there was less interference with the patient's normal daily activities. Overall the drugs were judged to be equally effective 8 .…”

“…Mefenamic acid, a drug used in the clinic for some 23 years for the management of mild to moderate pain, compares favourably with indomethacin 1 , sulindac 2 , diclofenac 3 and piroxicam 4 in the treatment of osteoarthritic pain. Mefenamic acid's analgesic efficacy also compares favourably with coproxamol 5 , diflunisal 6 and piroxicam 7 in the treatment of traumatic pain associated with soft tissue injuries or fractures.…”