Antiinflammatory, diuretic and antimicrobial activities of <i> Rungia pectinata</i> linn. and <i> Rungia repens</i> nees

Abstract

The hydroalcoholic extracts prepared from leaves of Rungia pectinata and Rungia repens were investigated for antiinflammatory and diuretic activity in wistar rats. The results obtained were compared with that of standard drug aspirin and frusemide for their antiinflammatory and diuretic activity respectively. The acute toxicity study was also carried out using adult swiss albino mice of either sex which indicates the safety of the extracts even at a dose of 4000 mg/kg. R. pectinata showed better anti-inflammatory activity than R. repens. In the present study, it was demonstrated that hydroalcoholic extracts of both R. repens and R. pectinata produce diuretic effect by increasing the excretion of Na+, K+ and Cl−. Results showed that R. repens is most effective in increasing urinary electrolyte concentration of Na+ and K+ ions. The antimicrobial potency of the aerial parts of Rungia pectinata and Rungia repens have been studied using the petroleum ether, benzene, chloroform, acetone and ethanol extract against a wide number of bacteria and fungi by disc diffusion method. The ethanol extract at a concentration of 30 to 60 μg/disc showed significant activity against the bacteria and fungus investigated. All the extracts of R. pectinata and R. repens have got moderate action but chloroform and acetone extracts of R. repens and ethanol extract of R. pectinata have got significant activity against Trichophyton mentagrophytes.

Natriuretic and saluretic effects of Hemidesmus indicus R. Br. root extracts in rats

“…Routine urinalysis including determination of pH and specific gravity along with presence of occult blood, bilirubin, urobilinogen, ketone bodies, proteins, nitrite, glucose, and leucocytes in urine was carried out using urocolor test strips (Standard Diagnostics Inc., South Korea) for urine samples of control and extract treated rats. Urine volume (ml/100 g) and Na + , K + and Cl - concentrations (mEq/l/100 g) in the urine were determined[ 15 ] and various indices for diuretic action were calculated. [ 14 16 17 ]…”

Studi Perbandingan Efek Diuretik Dan Antiinflamasi Gabungan Ekstrak Sidaguri, Tempuyung Dan Seledri Pada Tikus

“…Efek flavonoid sebagai diuretik sekaligus antiinflamasi dilaporkan oleh Swain et al (2008) dan Xiao et al 2005. Namun kekuatan efek antinflamasi flavonoid dari tanaman yang sama maupun berbeda tidak selalu sama tergantung pada pelarut, dan cara ekstraksi.…”

In vitro Antimicrobial Activity of Bangladeshi Artocarpus lakoocha Roxb Fruits

“…The antibacterial assay was performed using the paper disc diffusion method described by Navarro et al, 1998;Swain et al, 2008. Distinct concentrations of the fruit extracts (0.075, 0.10, 0.20, 0.40, 0.60, and 1.00mg/μl) were prepared with petroleum ether, chloroform and methanol.…”