Antiinflammatory, Antioxidant, and Immunological Effects of <scp><i>Carum copticum</i></scp> L. and Some of Its Constituents

Alavinezhad, Azam; Boskabady, Mohammad Hossein

doi:10.1002/ptr.5200

Cited by 21 publications

(14 citation statements)

References 66 publications

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“…In another study, anethole induced apoptosis, and combinations of anethole with cisplatin and oxaliplatin were highly synergistic (29). There are several other examples of phenolics such as p-cynene (ajowan and cumin), limonene (celery and caraway), thymol (ajowan) and β-pinene (cumin and celery) that have been shown to possess high antioxidant properties (30–32). In addition, the biological properties of polar and non-polar compounds from spices have been reviewed (33–35).…”

Section: Discussionmentioning

confidence: 99%

Potent Chemopreventive/Antioxidant Activity Detected in Common Spices of the Apiaceae Family

Jeyabalan

Aqil

Soper

et al. 2015

Nutrition and Cancer

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Spices are used worldwide, particularly, in the Asian and Middle-Eastern countries and considered protective against degenerative diseases, including cancer. Here, we report the efficacy of aqueous and non-aqueous extracts of eleven Apiaceae spices for free radical-scavenging activity and to inhibit cytochrome P450s in two separate reactions involving: i) 4-hydroxy-17β-estradiol (4E2), DNA and CuCl2 and ii) 17β-estradiol, rat liver microsomes, co-factors, DNA and CuCl2. Oxidative DNA adducts resulting from redox cycling of 4E2 were analyzed by 32P-postlabeling. Aqueous (5 mg/ml) and non-aqueous extracts (6 mg/ml) substantially inhibited (83% – 98%) formation of DNA adducts in the microsomal reaction. However, in non-microsomal reaction, only aqueous extracts showed the inhibitory activity (83% – 96%). Adduct inhibition was also observed at 5-fold lower concentrations of aqueous extracts of cumin (60%) and caraway (90%), and 10-fold lower concentrations of carrot seeds (76%) and ajowan (90%). These results suggests the presence of two groups of phytochemicals - polar compounds that have free radical-scavenging activity, and lipophilic compounds that selectively inhibit P450 activity associated with estrogen metabolism. Because most of these Apiaceae spices are used widely with no known toxicity, the phytochemicals from the Apiaceae spices used in foods may be potentially protective against estrogen-mediated breast cancer.

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Section: Discussionmentioning

confidence: 99%

Potent Chemopreventive/Antioxidant Activity Detected in Common Spices of the Apiaceae Family

Jeyabalan

Aqil

Soper

et al. 2015

Nutrition and Cancer

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“…Recently, phytochemicals are known to have or enhance antiinflammatory and/or cancer activity without showing cytotoxicity (Alavinezhad and Boskabady, ; Arumuggam et al , ; Chen et al , ; Lesgards et al , ; Parhiz et al , ; Shara and Stohs, ; Stohs and Bagchi, ; van Rensburg, ). These effects have drawn our interests to seek the possibility of controlling chronic inflammatory disease and cancer with minimal toxicity.…”

Section: Introductionmentioning

confidence: 99%

Flavonoids Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF‐α and IL‐β Through PI3K/Akt/NF‐kb Signaling Pathways

Han

Lee

Nagappan

et al. 2016

Phytotherapy Research

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Decoctions of the dried flowers of Lonicera japonica Thunb. (Indongcho) have been utilized in folk remedies against various inflammatory diseases, and it is reported neuroprotective effects. The cytokines release from microglia is closely linked to various chronic neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. It is still unknown whether the neuroprotective effects are associated with the antiinflammatory effects. Here, we determined whether polyphenols extracted from lyophilized Lonicera japonica Thunb. (PELJ) would inhibit inflammatory cytokines and mediators. We stimulated microglia with lipopolysaccharide (LPS) to produce inflammatory cytokines, and then assessed the effects of PELJ on these cytokines. PELJ significantly inhibited LPS-induced interleukin-1β and tumor necrosis factor-α expressions and LPS-induced nitric oxide (NO) and prostaglandin E expressions by down-regulating inducible enzyme NO synthase and cyclooxygenase-2 at the protein and mRNA levels. All the suppression of these mediators did not cause any significant cytotoxicity. PELJ also inhibited the nuclear translocation of nuclear factor-kappa B and phosphorylated Akt. These findings suggest that PELJ may offer substantial therapeutic potential for treating inflammatory and neurodegenerative diseases by inhibiting pro-inflammatory cytokines through inhibiting phosphoinositol 3-kinase /Akt/nuclear factor-kappa B signaling pathway. Copyright © 2016 John Wiley & Sons, Ltd.

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“…In addition to effects on bacteria, it may also be expected that plant compounds influence gene expression in intestinal cells (Inamuco et al, 2012). An overview of immune modulating effects of carvacrol has been provided by Alavinezhad and Boskabady (2014). Mechanisms for other potential therapeutic directions for carvacrol and cinnamaldehyde have also been reported (Gholami Mahtaj et al, 2015;Hong et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Cinnamaldehyde, Carvacrol and Organic Acids Affect Gene Expression of Selected Oxidative Stress and Inflammation Markers in IPEC‐J2 Cells Exposed to Salmonella typhimurium

Burt

Adolfse

Ahad

et al. 2016

Phytotherapy Research

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Essential oils and organic acids are used as feed additives to improve health status and reduce colonization with pathogens. Although bactericidal in vitro, concentrations achieved in the animal gut are probably not lethal to pathogens. The aim of this study was to investigate the effects of cinnamaldehyde, carvacrol and cinnamic, lactic and propionic acids on the ability of Salmonella typhimurium ATCC 14028 (ST) to invade intestinal epithelial cells (IPEC‐J2) and on the expression levels of immune related genes in the cells. The minimum inhibitory concentration (MIC) and non‐inhibitory concentration (NIC) were determined and influence on the invasion capacity of ST was investigated. The structure of fimbriae and flagella was analysed by electron microscopy, and expression levels of HSP70, IkBa, IL‐8 and IL‐10 in the IPEC‐J2 cells were carried out by q‐PCR. Cinnamaldehyde, carvacrol and cinnamic and propionic acids inhibited ST invasion but not cell viability, bacterial viability and motility or the development of flagella. Propionic acid and cinnamaldehyde in combination with cinnamic acid caused structural impairment of fimbriae. Cinnamaldehyde up‐regulated expression of HSP70 irrespective of the presence of organic acids or ST; exposure to carvacrol induced HSP70 only in the presence of propionic acid and ST. © 2016 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.

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Antiinflammatory, Antioxidant, and Immunological Effects of Carum copticum L. and Some of Its Constituents

Cited by 21 publications

References 66 publications

Potent Chemopreventive/Antioxidant Activity Detected in Common Spices of the Apiaceae Family

Potent Chemopreventive/Antioxidant Activity Detected in Common Spices of the Apiaceae Family

Flavonoids Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF‐α and IL‐β Through PI3K/Akt/NF‐kb Signaling Pathways

Cinnamaldehyde, Carvacrol and Organic Acids Affect Gene Expression of Selected Oxidative Stress and Inflammation Markers in IPEC‐J2 Cells Exposed to Salmonella typhimurium

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