Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences

Abiodun, Olufunmilola Adunni; Rodríguez-Nogales, Alba; Algieri, Francesca; Gómez-Caravaca, Ana María; Segura‐Carretero, Antonio; Utrilla, M. Pilar; Rodríguez-Cabezas, M. Elena; Gálvez, Júlio

doi:10.1016/j.jep.2016.07.056

Cited by 60 publications

(29 citation statements)

References 46 publications

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“…Ethanol extract of stem bark of Terminalia catappa Linn . did not cause cell damage when tested at 5 to 100 μg/ml against RAW 264.7 cells and two fractions of acidic polysaccharides isolated from Combretum racemosum P. Beauv . also did not induce deleterious effect on PBMCs or MonoMac‐6 cells when tested from 10 to 250 μg/ml .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves ofConocarpus erectusLinnaeus (Combretaceae)

Santos

Almeida

Araújo

et al. 2018

Journal of Pharmacy and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves ofConocarpus erectusLinnaeus (Combretaceae)

Santos

Almeida

Araújo

et al. 2018

Journal of Pharmacy and Pharmacology

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“…These results are consistent with those from studies carried out on other species of Terminalia. These also demonstrated dose-dependent hepatoprotective properties by reducing transaminases and alkaline phosphatase such as T. bellirica fruits [14] and Terminalia catappa leaves [15].…”

Section: Requested Items For Marketing Authorization Deliverymentioning

confidence: 99%

“…Distilled analyses allowed us to highlight the presence of tannins and triterpenes. Phenolic compounds are widely described in the literature for their potential biological activity such as anti-inflammatory and immunomodulatory effects [15,16]. They are excellent antioxidants due to the presence of a hydroxyl group capable of capturing oxygen free radicals [17].…”

Section: Thickness Of Paw (Mm) % Inhibition 0 H 1 H 3 H 5 H 1 H 3 H 5 Hmentioning

confidence: 99%

Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera

Haïdara

Dénou

Haddad

et al. 2020

Planta Medica International Open

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In Mali, improved traditional medicines [“Médicaments Traditionnels Améliorés”] are prepared from traditionally used medicinal plants. Recently, the Department of Traditional Medicine has identified Terminalia macroptera Guill. & Perr. (Combretaceae) as a potential candidate for an improved traditional medicine. T. macroptera is a West African medicinal plant used in Mali against various health disorders, with more than 30 different indications mentioned by traditional healers, including hepatitis, gonorrhea, fever, pain relief, and various infectious diseases (Helicobacter pylori-associated diseases). To date, validation of most of the biological activities of has been mainly carried out in vitro, except for antimalarial activities. In this study, the potential anti-inflammatory, antipyretic, analgesic, and hepatoprotective properties of T. macroptera were investigated in different murine models. Administration of T. macroptera ethanolic root and leaf extracts in rats significantly reduced pyrexia, pain, inflammation, and hepatic marker enzymes such as alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase in the different murine models used (p<0.05). A phytochemical screening of T. macroptera revealed the presence of tannins, flavonoids, saponins, anthracene derivatives, sterols, triterpenes, and sugars in both leaf and root extracts as the main phytochemical compounds. This was confirmed by qualitative analysis, liquid chromatography coupled with high-resolution mass spectrometry. T. macroptera extracts demonstrated interesting in vivo antipyretic, analgesic, anti-inflammatory, and hepatoprotective activities. Therefore, T. macroptera should be proposed and further evaluated as a potential improved traditional medicine for the treatment of liver-related disorders and for the relief of pain and fever.

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“…Terminalia catappa L. belongs to the family Combretaceae, and in Southeast Asia, it is commonly used as a folk medicine for treating hepatoma and hepatitis [ 14 , 15 ]. The leaf and bark extracts of T. catappa have been reported to exhibit chemopreventive, antioxidant, hepatoprotective, and anti-inflammatory activities [ 16 , 17 ]. T. catappa includes the phytochemicals of flavanoids (rutin, isoorientin, vitexin, and isovitexin), tannins (chebulagic acid, punicalagin, punicalin, and terflavins A and B), and triterpenoids (asiatic acid and ursolic acid) [ 14 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Protective effects and mechanisms of Terminalia catappa L. methenolic extract on hydrogen-peroxide-induced oxidative stress in human skin fibroblasts

Huang

Wen

et al. 2018

BMC Complement Altern Med

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BackgroundOxidative stress plays a crucial role in aging-related phenomenon, including skin aging and photoaging. This study investigated the protective role and possible mechanism of Terminalia catappa L. methanolic extract (TCE) in human fibroblasts (Hs68) against hydrogen peroxide (H2O2)-induced oxidative damage.MethodsVarious in vitro antioxidant assays were performed in this study. The effect and mechanisms of TCE on oxidative stress-induced oxidative damage were studied by using western blotting.ResultsThe IC50 of TCE was 8.2 μg/mL for 1,1-diphenyl-2-picrylhydrazyl radical scavenging, 20.7 μg/mL for superoxide anion radical scavenging, 173.0 μg/mL for H2O2 scavenging, 44.8 μg/mL for hydroxyl radical scavenging, and 427.6 μg/mL for ferrous chelation activities. Moreover, TCE inhibited the H2O2-induced mitogen-activated protein kinase signaling pathway, resulting in the inhibition of c-Jun, c-Fos, matrix metalloproteinase (MMP)-1, MMP-3, MMP-9, and cyclooxygenase-2 expression. TCE also increased hemeoxygenase-1 expression inhibited by H2O2. Finally, TCE was demonstrated reverse type I procollagen expression in fibroblasts after H2O2 treatment.ConclusionsAccording to our findings, TCE is a potent antioxidant and protective agent that can be used in antioxidative stress-induced skin aging.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2308-4) contains supplementary material, which is available to authorized users.

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Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences

Cited by 60 publications

References 46 publications

Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves ofConocarpus erectusLinnaeus (Combretaceae)

Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves ofConocarpus erectusLinnaeus (Combretaceae)

Evaluation of Anti-inflammatory, Anti-pyretic, Analgesic, and Hepatoprotective Properties of Terminalia macroptera

Protective effects and mechanisms of Terminalia catappa L. methenolic extract on hydrogen-peroxide-induced oxidative stress in human skin fibroblasts

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