Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves of<i>Conocarpus erectus</i>Linnaeus (Combretaceae)

Mangroves speak to regions of high organic profitability and it is a locale wealthy in bioactive substances utilized in medication invention. Conocarpus erectus has placed in the family Combretaceae, in one of the two species of Conocarpus genus and ordinarily exists in tropical and subtropical regions of the world, right through West Indies, America and Africa. The fundamental goal of this audit was to draw attention to the applicable reported information distributed about its phytochemistry, therapeutic potential, botanical aspects as well as traditional uses of Conocarpus erectus. C. erectus is an evergreen tree with 20cm in diameter and 6m tall with scattering crown. This plant was selected because of its huge medicinal importance. The extract of Conocarpus erectus (leaves, shoot, bark & fruit) parts shows high antibacterial, antioxidant and hepta-protective activities due to phenolic content. It contains phenol such as tannin and flavinoid as major component. Tannin has high antibacterial activity than other compound. C. erectus is notable for its folkloristic curative potential.

show abstract

Section: Botanical Description and Habitat Of Conocarpusmentioning

confidence: 86%

Phytochemical Activities of Conocarpus Erectus: An Overview

Khalil

Ali

Hafeez

et al. 2020

Biol Clin Sci Res J

View full text Add to dashboard Cite

show abstract

“…Conocarpus erectus leaf extract showed that C. erectus leaves had antioxidant and antibacterial feature. These discoveries add to logical data for the adequacy on utilization of this plant in the advancement of a phytotherapic compounds, (Santos et al, 2018). In this work to check out the antibacterial activity of Conocarpus erectus parts shoot, bark, fruit and leaves against Gram positive S. aureus strain and Gram negative (E. coli, K. pneumonia) strains.…”

Section: Erectus Fruit Discussionmentioning

confidence: 99%

Phenolic Acid Profiling by Rp-Hplc: Evaluation of Antibacterial and Anticancer Activities of Conocarpus Erectus Plant Extracts

Khalil

Ali

Hafeez

et al. 2020

Biol Clin Sci Res J

View full text Add to dashboard Cite

Due to the versatile application of plants the utilization of plants and their inferred substances builds up day by day for the revelation of new curative agents. Conocarpus erectus has placed in the family Combretaceae, in one of the two species of Conocarpus genus and ordinarily exists in tropical and subtropical regions of the world. In some countries it is used as folk medicine for fever, anemia, diabetes, catarrh, diarrhea and conjunctivitis. The current study was carried out to investigate the antibacterial and anticancer properties of the plant. The four defatted methanol extracts of C. erectus different parts (leaves, stems, fruits and bark) showed high antibacterial and anticancer activity even with small quantity of dose. Antimicrobial assay was used to check out the antibacterial activity against 6 bacterial strains Escherichia coli, Staphylococcus Aureus and Klebstella Pneumoniae. The results show that gram positive bacteria show more sensitivity and zone of inhibition as compared to gram negative bacteria. For anticancer activity, MTT assay was performed on HepG2 cells for this purpose. Plant extorts show anticancer activity with a minute quantity. For phytochemical screening defatted methanol extract of Conocarpus erectus was subjected to the silica gel glass column go behind by (RP-HPLC–UV–ESI-MS). It contains phenol such as tannin and flavinoid as major component. Plant contain Ellagic acid; di-hexahydroxy diphenyl, Vascalgin isomer as foremost tannin component. Gallic Acid, Kaempferol on the base of mass spectra and time of retention. The extract of Conocarpus erectus (leaves, shoot, bark & fruit) parts shows high antibacterial, antioxidant and hepta-protective activities due to phenolic content. Tannin has high antibacterial activity than other compound. C.erectus is notable for its folkloristic curative potential. More in vivo and in vitro phytochemical studies are needed to use the plant for prevention and treatment of many diseases.

show abstract

“…For each extract, 10 µL (5 mg/ml) were spotted on the TLC plate. The same revealers as in Santos et al (Santos et al, 2018) were used, except for total and condensed tannins, for which ferric chloride (Oliveira et al, 2015) and DMACA (Lea, 1978) (Sigma-Aldrich) were used. Folin-Ciocalteu reagent (VWR chemicals) was also used to reveal all the polyphenols.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Anti-HCV Tannins From Plants Traditionally Used in West Africa and Extracted With Green Solvents

et al. 2022

View full text Add to dashboard Cite

Millions of people are still infected with hepatitis C virus (HCV) nowadays. Although recent antivirals targeting HCV proteins are very efficient, they are not affordable for many people infected with this virus. Therefore, new and more accessible treatments are needed. Several Ivorian medicinal plants are traditionally used to treat “yellow malaria”, a nosological category including illness characterized by symptomatic jaundice such as hepatitis. Therefore, some of these plants might be active against HCV. An ethnobotanical survey in Côte d’Ivoire allowed us to select such medicinal plants. Those were first extracted with methanol and tested for their anti-HCV activity. The most active ones were further studied to specify their IC50 and to evaluate their toxicity in vitro. Greener solvents were tested to obtain extracts with similar activities. Following a phytochemical screening, tannins of the most active plants were removed before re-testing on HCV. Some of these tannins were identified by UPLC-MS and pure molecules were tested against HCV. Out of the fifteen Ivorian medicinal plants selected for their putative antiviral activities, Carapa procera DC. and Pericopsis laxiflora (Benth. ex Baker) Meeuwen were the most active against HCV (IC50: 0.71 and 0.23 μg/ml respectively) and not toxic for hepatic cells. Their crude extracts were rich in polyphenols, including tannins such as procyanidins A2 which is active against HCV. The same extracts without tannin lost their anti-HCV activity. Replacing methanol by hydro-ethanolic solvent led to tannins-rich extracts with similar antiviral activities, and higher than that of aqueous extracts.

show abstract

Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves ofConocarpus erectusLinnaeus (Combretaceae)

Abstract: AELCe showed a moderate bacteriostatic activity and promoted an immunomodulatory status through higher production of Th1 cytokines, nitric oxide release and T CD8 lymphocytes stimulation.

Cited by 21 publications

References 32 publications

Phytochemical Activities of Conocarpus Erectus: An Overview

Phytochemical Activities of Conocarpus Erectus: An Overview

Phenolic Acid Profiling by Rp-Hplc: Evaluation of Antibacterial and Anticancer Activities of Conocarpus Erectus Plant Extracts

Anti-HCV Tannins From Plants Traditionally Used in West Africa and Extracted With Green Solvents

Contact Info

Product

Resources

About