Antiinflammatory and antioxidant activity of <i>Hypericum sinaicum</i> Boiss. growing widely in Egypt

El‐Hawary, Seham S.; Ahmed, Fatma; Sheashea, Mohamed; Ezzat, Marwa I.

doi:10.1080/14786419.2021.1931191

Cited by 3 publications

(7 citation statements)

References 10 publications

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“…Inhibition of the cyclooxygenase pathway can have a wider effect because the cyclooxygenase reaction is the first step in the pathway to eicosanoids such as prostaglandins and thromboxane. In addition to flavonoids, it is known that triterpenoid and saponin compounds are thought to play an anti-inflammatory role [26].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-inflammatory Activities of Extract Ethanol Curcuma zedoaria

Anggraeni

Ginting

Chiuman

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Inflammation is a response of the body to injury or infection. When an injury occurs, the body will try to neutralize and eliminate harmful agents from the body and prepare for tissue repair. White turmeric is known to have secondary metabolites that have pharmacological activities such as antioxidants, antihyperlipidemia, antidiabetic and others. AIM: This study aims to determine the anti-inflammatory, antioxidant, total phenol and flavonoid activity of white turmeric ethanol extract. MATERIALS AND METHODS: This study used carrageenan as an inflammatory inducer. This study was divided into 5 groups, namely the normal group, the CMCNa group, the EEKP group at a dose of 300 mg/kg, the EEKP group at a dose of 600 mg/kg, and 900 mg/kg. And in this study, measurements of IC50, total flavonoids, and total phenol of white turmeric ethanol extract were carried out. The results showed that the ethanol extract of white turmeric at doses of 300, 600, and 900 mg/kgbw had anti-inflammatory activity by decreasing the percentage of inflammation and increasing the percentage of inflammation inhibition. The dose of 600 mg/kgbw had no statistically significant difference (p>0.05) with the diclofenac sodium group. RESULTS: Analysis of the results of inflammatory infiltration in gastric histopathology in groups P1, P2, P3 and P4 showed mild inflammatory infiltration compared to groups P(5) and K(+). While the description of the acinar glands on gastric histopathology showed that the P2 group gave a better picture of the acinar gland repair than the K(+), P2, P3, P4 and P5 groups. CONCLUSION: It can be concluded that white turmeric ethanol extract has anti-inflammatory and antioxidant activity.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and Anti-inflammatory Activities of Extract Ethanol Curcuma zedoaria

Anggraeni

Ginting

Chiuman

et al. 2022

Open Access Maced J Med Sci

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“…Comparatively, polyprenylated acylphloroglucinol i.e., hyperforins were imposed in H. sinaicum with the highest content of 0.989% (w/w) among other Hypericum plants growing in Jordon 7 . Moreover, naringenin and syringic acid were found to be the major phenolic constituents, with 50.31mg/g and 0.37mg/g, respectively, in H. sinaicum 4 . Further, hypericins were also detected in fungi, i.e., dermocybe fungi or endophytic fungi which grow in Hypericum species.…”

Section: Introductionmentioning

confidence: 95%

“…Other species of Hypericum could be endemic to certain regions, such as H. sinaicum, which is endemic to Egypt within Saint Katherine Protectorate (SKP), Jordan, and Northwest Saudi Arabia. 4 . According to the International Union for Conservation of Nature (IUCN), H. sinaicum was recorded as a rare plant species in 1994 and it is often abundant at high altitude areas from 396 to 2642m above sea level.…”

Section: Introductionmentioning

confidence: 99%

UPLC-MS-based metabolomics profiling and chemometric analysis for Hypericum sinaicum Boiss and the endophytic Aspergillus foetidus in comparison to Hypericum perforatum L

Sheashea

El‐Hawary

Ahmed

et al. 2022

Preprint

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One of the endangered plant species in Saint Catherine protectorate is Hypericum sinaicum Boiss which is endemic to Egypt, Jordan, and Saudi Arabia. Isolating the endophytic fungus Aspergillus foetidus var. pallidus provided a sustainable alternative to H. sinaicum rarity in terms of the plant's potential. The fungus-host relationship can assist in the investigation of bioactive compounds produced by H. sinaicum paving the way for economic and medicinal implications. Therefore, a comprehensive metabolic approach via MS and chemical analysis was used to track and compare metabolites from H. sinaicum and A. foetidus with Hypericum perforatum. Metabolomics analysis revealed the presence of 25 metabolites distributed among samples and the discovery of new chemotaxonomic compounds, i.e., phloroglucinols and xanthones, allowing the discrimination between species. Moreover, A. foetidus extract is considered a reliable source of furohyperforin and naphthodianthrone derivatives. In conclusion, using A. foetidus as an in vitro technique for producing potential phytoconstituents was cost effective, having easier optimization conditions and faster growth with fewer contamination rates than other in vitro methods.

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“…Other species of Hypericum could be endemic to certain regions, such as H. sinaicum , which is endemic to Egypt within Saint Katherine Protectorate (SKP), Jordan, and Northwest Saudi Arabia. [4] . According to the International Union for Conservation of Nature (IUCN), H. sinaicum Hochst.…”

Section: Introductionmentioning

confidence: 99%

“…H. perforatum is a flowering perennial plant native to Eurasia that has spread to North and South America, parts of Africa, Australia, and New Zealand.. [3] The popularity of H. perforatum forces the scientific community to study other species as the genus Hypericaceae is distributed almost everywhere on Earth. Other species of Hypericum could be endemic to certain regions, such as H. sinaicum, which is endemic to Egypt within Saint Katherine Protectorate (SKP), Jordan, and Northwest Saudi Arabia.. [4] According to the International Union for Conservation of Nature (IUCN), H. sinaicum Hochst. ex Boiss was recorded as a rare plant species in 1994 and it is often abundant at high altitude areas from 396 to 2642m above sea level.…”

Section: Introductionmentioning

confidence: 99%

UPLC‐MS‐Based Metabolomics Profiling and Chemometric Analysis for Hypericum sinaicum Boiss and the Endophytic Aspergillus foetidus in Comparison to Hypericum perforatum L.

Sheashea,

El‐Hawary,

Ahmed

et al. 2023

Chemistry & Biodiversity

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One of the endangered plant species in Saint Catherine protectorate is Hypericum sinaicum Boiss which is endemic to Egypt, Jordan, and Saudi Arabia. The fungus‐host relationship can assist in the investigation of bioactive compounds produced by H. sinaicum paving the way for economic and medicinal implications. Therefore, a comprehensive metabolic approach via MS and chemical analysis was used to track and compare metabolites from H. sinaicum and Aspergillus foetidus var. pallidus, the endophytic fungus, with Hypericum perforatum. Metabolomics analysis revealed the presence of 25 metabolites distributed among samples and the discovery of new chemotaxonomic compounds, i.e., phloroglucinols and xanthones, allowing the discrimination between species. A. foetidus extract is considered a reliable source of furohyperforin and naphthodianthrone derivatives. In conclusion, using A. foetidus as an in vitro technique for producing potential phytoconstituents was cost effective, having easier optimization conditions and faster growth with fewer contamination rates than other in vitro methods.

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Antiinflammatory and antioxidant activity of Hypericum sinaicum Boiss. growing widely in Egypt

Cited by 3 publications

References 10 publications

Antioxidant and Anti-inflammatory Activities of Extract Ethanol Curcuma zedoaria

Antioxidant and Anti-inflammatory Activities of Extract Ethanol Curcuma zedoaria

UPLC-MS-based metabolomics profiling and chemometric analysis for Hypericum sinaicum Boiss and the endophytic Aspergillus foetidus in comparison to Hypericum perforatum L

UPLC‐MS‐Based Metabolomics Profiling and Chemometric Analysis for Hypericum sinaicum Boiss and the Endophytic Aspergillus foetidus in Comparison to Hypericum perforatum L.

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