Antiinflammatory activity of natural triterpenes—An overview from 2006 to 2021

Miranda, Rodrigo de Souza; Jesus, Bárbara da Silva Mascarenhas de; Luiz, Sandra Regina da Silva; Viana, Cristina Borges; Malafaia, Camila Rodrigues Adão; Figueiredo, Fabiana de Souza; Carvalho, Tatiane dos Santos Conceição; Silva, Matheus L.; Londero, Vinicius S.; Costa-Silva, Thaís A.; Lago, João Henrique G.; Martins, Roberto Carlos Campos

doi:10.1002/ptr.7359

Cited by 30 publications

(17 citation statements)

References 183 publications

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“…Terpenoids are one of the most abundant components of secondary metabolites produced by plants. As shown in Figure 7 , the anti-inflammatory effects of many terpenes have been confirmed by many studies [ 204 , 205 ].…”

Section: Natural Products With Anti-inflammatory Effects In Alzheimer...mentioning

confidence: 54%

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Deng

Yan

et al. 2023

Molecules

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Alzheimer’s disease (AD) is an age-related chronic progressive neurodegenerative disease, which is the main cause of dementia in the elderly. Much evidence shows that the onset and late symptoms of AD are caused by multiple factors. Among them, aging is the main factor in the pathogenesis of AD, and the most important risk factor for AD is neuroinflammation. So far, there is no cure for AD, but the relationship between neuroinflammation and AD may provide a new strategy for the treatment of AD. We herein discussed the main etiology hypothesis of AD and the role of neuroinflammation in AD, as well as anti-inflammatory natural products with the potential to prevent and alleviate AD symptoms, including alkaloids, steroids, terpenoids, flavonoids and polyphenols, which are available with great potential for the development of anti-AD drugs.

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Section: Natural Products With Anti-inflammatory Effects In Alzheimer...mentioning

confidence: 54%

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Deng

Yan

et al. 2023

Molecules

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“…Triterpenoids are composed mainly of six isoprene units, of which pentacyclic triterpenes are the most common and exhibit strong antiviral activity. The main types of pentacyclic triterpene skeletons are oleanolane, ursolidane, lupinane, and corkolidane ( Miranda et al, 2022 ).…”

Section: Terpenoidsmentioning

confidence: 99%

Research progress on the antiviral activities of natural products and their derivatives: Structure–activity relationships

Guo

Ma²,

Wang³

et al. 2022

Front. Chem.

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Viruses spread rapidly and are well-adapted to changing environmental events. They can infect the human body readily and trigger fatal diseases. A limited number of drugs are available for specific viral diseases, which can lead to non-efficacy against viral variants and drug resistance, so drugs with broad-spectrum antiviral activity are lacking. In recent years, a steady stream of new viral diseases has emerged, which has prompted development of new antiviral drugs. Natural products could be employed to develop new antiviral drugs because of their innovative structures and broad antiviral activities. This review summarizes the progress of natural products in antiviral research and their bright performance in drug resistance issues over the past 2 decades. Moreover, it fully discusses the effect of different structural types of natural products on antiviral activity in terms of structure–activity relationships. This review could provide a foundation for the development of antiviral drugs.

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“…According to the number of rings in the structure, triterpenoids can be classified into monocyclic triterpenes, bicyclic triterpenes, tricyclic triterpenes, tetracyclic triterpenes, and pentacyclic triterpenes, etc. Among them, pentacyclic triterpenoids have received more attention because of more types and functions [ 10 , 11 , 12 , 13 ]. Biologically, triterpene saponins are considered to be defensive compounds against external stresses [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome Analyses Revealed the Key Metabolic Genes and Transcription Factors Involved in Terpenoid Biosynthesis in Sacred Lotus

Qin

Yang

et al. 2022

Molecules

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As the largest group of structurally diverse metabolites, terpenoids are versatile natural compounds that act as metabolism mediators, plant volatiles, and ecological communicators. However, few terpenoid compounds have been identified in plant parts of sacred lotus (Nelumbo nucifera Gaertn.). To elucidate the molecular genetic basis of the terpene biosynthetic pathway, terpenes from different parts of the plant, including seeds (S), young leaves (YL), mature leaves (ML), white flowers (WF), yellow flowers (YF), and red flowers (RF), were identified by LC-MS/MS and the relative contents of the same terpenes in different parts were compared. The results indicate that all plant parts primarily consist of triterpenes, with only minor quantities of sesquiterpenes and diterpenes, and there were differences in the terpene content detected in different plant parts. To illustrate the biosynthesis of various terpenoids, RNA sequencing was performed to profile the transcriptomes of various plant parts, which generated a total of 126.95 GB clean data and assembled into 29,630 unigenes. Among these unigenes, 105 candidate unigenes are involved in the mevalonate (MVA) pathway, methyl-erythritol phosphate (MEP) pathway, terpenoid backbone biosynthesis pathway, and terpenoid synthases pathway. Moreover, the co-expression network between terpene synthase (TPS) and WRKY transcription factors provides new information for the terpene biosynthesis pathway.

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Antiinflammatory activity of natural triterpenes—An overview from 2006 to 2021

Cited by 30 publications

References 183 publications

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Research progress on the antiviral activities of natural products and their derivatives: Structure–activity relationships

Transcriptome Analyses Revealed the Key Metabolic Genes and Transcription Factors Involved in Terpenoid Biosynthesis in Sacred Lotus

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