Antiinflammatory Activity of Heat-treated <i>Cassia alata</i> Leaf Extract and Its Flavonoid Glycoside

Abstract

Antiin‰ammatory activities of heat-treated Cassia alata leaf extract and kaempferol 3-O-gentiobioside(K3G) isolated from C. alata as an abundant ‰avonoid glycoside were studied by comparing their activities with the activities of sun-dried C. alata leaf extract. We observed strong inhibitory eŠects on Concanavalin A-induced histamine release from rat peritoneal exudate cells both in the extracts of heat-treated and sun-dried C. alata leaves. Furthermore, the heattreated leaf extract exhibited stronger inhibitory eŠects than the eŠects of the sun-dried leaf extract at low concentrations in the studies of Concanavalin A-induced histamine release, 5-lipoxygenase inhibition, and also inhibition of cyclooxygenases (COX-1 and COX-2), whereas K3G showed weak inhibitory eŠects on Concanavalin A-induced histamine release, 5-lipoxygenase, and COX-1. No anti-hyaluronidase eŠect was detected in any of the materials tested.

Study of Antioxidant Activity and Immune Stimulating Potency of the Ethnomedicinal Plant, Cassia alata (L.) Roxb

“…The leaves of C. alata have been qualitatively analyzed for the presence of primarily five pharmacologically active anthraquinones: rhein, aloeemodin, chrysophanol, emodin and physcion, as well as the flavonoid, kaempferol [18]. The flavonoid, kaempferol has been reported to have anticancer properties [33].…”

“…Pharmacological investigations performed so far on Cassia alata have revealed that this herb has several biological activities, such as antimicrobial [14,15], purgative [16], anti-inflammatory [17,18], analgesic [17,19,20], hypoglycaemic [17], and antitumor activities [21].…”

“A thing of beauty is a joy forever”. Plants and plant-based preparations for facial care in Suriname

“…Some of these compounds have been associated with the laxative and purgative properties of S. alata preparations [183,184]; their efficacy against scabies and ringworm infections as well as fungal infections of the skin such as Pityriasis versicolor [185]; their antibacterial effects [186], their anti-inflammatory activity [187], and their capacity to reduce ultraviolet irradiation-induced skin damage [188]. For these reasons, S. alata leaf extracts are included in many cosmetics and dermatological skin care products such as soaps, sunscreens, anti-ageing agents, and skin-repairing agents [189].…”

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

“…In Suriname, root extracts from C. alata are used for the treatment of uterus disorders [1]. Pharmacological investigations performed so far on C. alata have shown that this herb has several biological activities, such as antimicrobial [8,9], antifungal [2,10,11], purgative [4], anti-inflammatory [11,12], analgesic [1,11,13], antitumor [14], and hypoglycaemic [11] activities.…”