Antihypertensive Prescription Pattern and Compliance to JNC 7 and JNC 8 at Tertiary Care Government Hospital, Hyderabad, India: A Cross-sectional Retrospective Study

Varakantham, Varsha; Sailoo, Ashok Kumar Kurakula; Bharatraj, Dinesh Kumar

doi:10.1177/0018578717738080

Cited by 11 publications

(9 citation statements)

References 29 publications

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“…The analysis of this study population shows that 53% had CAD, 46.6% had diabetes, 42% had dyslipidemia, 13.4% had hypothyroidism, 5.8% had CKD, and 5.2% had Stroke. Akintunde et al also found similar result in their study [13].…”

Section: Anuradha Et Alsupporting

confidence: 78%

Drug Utilization Pattern of Antihypertensive Medications in a Tertiary Care Hospital, South India

VP¹,

MUHAS²,

S³

2021

Asian J Pharm Clin Res

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Objective: The objective of the study is to assess drug use pattern of antihypertensive medications in hypertensive patients. Methods: It is a prospective cross-sectional study conducted in the outpatient dispensary, Government Medical College, Thiruvananthapuram for the period of 6 months from January 2019 to June 2019. About 500 prescriptions of patients visiting outpatient dispensary with an antihypertensive prescription were enrolled for the study. Drug use patterns of different classes of antihypertensive medications were analyzed from individual prescriptions. Results: A total of 500 patients were included in this study, among which 281 were male (56.2%) and 219 (43.8%) were female. In 500 patients, 133 patients were treated with monotherapy. In that 42.1% of patients were treated with amlodipine, 28.57% of patients were treated with losartan. In combination therapy most commonly used was double therapy (42.8%) followed by triple therapy (24.2%). Calcium Channel Blockers (56.2%) was most prescribed class of drug followed by Angiotensin Receptor Blockers. Conclusion: This study reveals that calcium channel blockers as most prescribed class of antihypertensive and Amlodipine was the most prescribed antihypertensive. In our study, most of the patients were treated with combination therapy in that double drug therapy was most common. There is a chance of various medication errors, development of adverse drug reaction as majority (290) of patients belong to age above 60 and chances of getting error also increases as combination therapy is most used. Therefore close monitoring is required for such patients.

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Section: Anuradha Et Alsupporting

confidence: 78%

Drug Utilization Pattern of Antihypertensive Medications in a Tertiary Care Hospital, South India

VP¹,

MUHAS²,

S³

2021

Asian J Pharm Clin Res

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“…Although thiazide-type diuretics were recommended as initial therapy for most patients [ 37 ], it was observed that the prescription proportion was fairly lower than that of ARBs and CCBs in the current study. The low preference for diuretics may be related to their adverse effects such as hypokalaemia.…”

Section: Discussionmentioning

confidence: 55%

Analysis of prescription status of antihypertensive drugs in Chinese patients with hypertension based on real-world study

et al. 2023

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Background Globally, the prevalence of hypertension and the accompanying burden of cardiovascular disease are increasing. Through drug utilization research, we can understand the prescription status of hypertension patients and promote rational drug use. The purpose of this retrospective study was to describe the current prescription pattern of antihypertensive drugs in Chinese patients and determine the compliance level of treatment guidelines. Materials and methods Around 11.1 million patients who received a prescription for antihypertensive therapy between January 2021 to December 2021 were obtained from a database of Hangzhou Kang Sheng Health Consulting CO., Ltd. Results The mean age of hypertensive patients was 54.75 ± 12.98 years. About 6.7 million (60.30%) were males. About 46.07% of patients had comorbidities. The most common classes of antihypertensive medications used were calcium channel blockers (CCBs) and angiotensin II receptor blockers (ARBs). Around 78.33% of participants were on monotherapy. Diuretics + ARBs and Diuretics + CCBs + ARBs were the most commonly prescribed pattern in two-drug combination therapy and three-drug combination therapy, respectively. Conclusions CCBs and ARBs were the two most frequently prescribed for patients with hypertension. The prescription pattern of antihypertensive medications in the study largely complied with recommended Chinese hypertension guidelines. Key messages Cardiovascular disease is the most common complication of hypertension. Calcium channel blockers (CCBs) and angiotensin II receptor blockers (ARBs) are the two most commonly used drugs for hypertension patients in China. The proportion of combination prescription pattern in Chinese hypertensive patients is low.

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“…The thiazide diuretics were the least prescribed medicine, thus deviating from the JNC guidelines. They concluded that the combination therapy regimen must be followed as stipulated in the guidelines for the achievement of appropriate blood pressure goals [10]. It should, however, be noted that combination therapies predispose patients to drug therapy problems, especially drug-drug interactions [11,12].…”

Section: Discussionmentioning

confidence: 99%

Adherence to Essential Hypertension Treatment Guidelines in a Tertiary Hospital in Nigeria

Ibezim

Naylor

Isah

et al. 2020

Int J Pharm Pharm Sci

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Objective: This study determined the level of prescribers’ adherence to the World Health Organization/International Society of Hypertension (WHO/ISH) guidelines for the management of hypertension at the Lagos University Teaching Hospital (LUTH), Nigeria. Methods: This study employed a retrospective cross-sectional design. Two groups were used: Group A (300 patients) were treated before the guidelines review in 2003, while Group B (200 patients) were treated after. The two study groups were compared, and systolic blood pressure of 130 mm Hg or above was taken as the index of hypertension. Results: There were 198 (66%) male patients in Group A, while Group B had 136 (68%) males. The highest age for Group A was 50–59 y for 89 (30%) patients, unlike group B that had 58 (29%) patients in aged 40–49 y as the highest. The highest blood pressure range for patients in Group A was 150–159 mm Hg for 64 (21%) patients, unlike Group B that had 43 (22%) patients as the highest in the same range. Furosemide was present in 282 (24%) prescriptions for group A patients. However, atenolol was present in 61 (20%) prescriptions for the same group. In group B, Furosemide was prescribed in 197 (97%) encounters, while Nifedipine was found in 81(40%) prescriptions. Conclusion: Prescribers at LUTH complied substantially with WHO/ISH guidelines in the management of hypertension. Diuretics and beta-blockers were used before the guideline review. After the review, diuretics and calcium channel blockers were the most frequently prescribed antihypertensives.

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Antihypertensive Prescription Pattern and Compliance to JNC 7 and JNC 8 at Tertiary Care Government Hospital, Hyderabad, India: A Cross-sectional Retrospective Study

Cited by 11 publications

References 29 publications

Drug Utilization Pattern of Antihypertensive Medications in a Tertiary Care Hospital, South India

Drug Utilization Pattern of Antihypertensive Medications in a Tertiary Care Hospital, South India

Analysis of prescription status of antihypertensive drugs in Chinese patients with hypertension based on real-world study

Adherence to Essential Hypertension Treatment Guidelines in a Tertiary Hospital in Nigeria

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