Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway

Oyagbemi, Ademola Adetokunbo; Omóbòwálé, Temidayo Olutayo; Adejumobi, Olumuyiwa Abiola; Owolabi, Abiodun M.; Ogunpolu, Blessing Seun; Falayi, Olufunke Olubunmi; Hassan, Fasilat Oluwakemi; Ogunmiluyi, Iyanuoluwa Omolola; Asenuga, Ebunoluwa Racheal; Ola‐Davies, Olufunke Eunice; Soetan, K. O.; Saba, Adebowale Benard; Adedapo, Adeolu Alex; Nkadimeng, Sanah Malomile; McGaw, Lyndy Joy; Oguntibeju, Oluwafemi Omoniyi; Yakubu, Momoh Audu

doi:10.1016/j.ejphar.2020.173142

Cited by 22 publications

(11 citation statements)

References 81 publications

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“…Similarly, chrysin shows an excellent anti-hypertensive effect in SHR and N(ω)-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats (145,146). This effect has also been reported for catechin (147), epigallocatechin gallate (148), hesperidin (149), and other flavonoids (150) in various animal models of hypertension. Noticeably, these studies demonstrate that flavonoids do not modify blood pressure in on normotensive rats.…”

Section: Flavonoids Improve Hypertensionmentioning

confidence: 67%

Flavonoids and cardiovascular risk factors: a review

Alayoud¹

2021

Pharm Adv

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Section: Flavonoids Improve Hypertensionmentioning

confidence: 67%

Flavonoids and cardiovascular risk factors: a review

Alayoud¹

2021

Pharm Adv

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Section: Discussionmentioning

confidence: 99%

“…In this study, we selected naringenin in a dosage range from 25 to 100 mg/kg, according to previously reported studies [19, 25]. Oyagbemi et al [25] reported that naringenin at a dose of 50 mg/kg exhibits antihypertensive and neuroprotective effects in hypertensive rats. Another study initiated by Ahmed et al [19] found that treatment with naringenin at a dose of 50 mg/kg for 3 weeks ameliorates oxidative stress, inflammation, and nitric oxide in hypertensive rats induced by monocrotaline.…”

Section: Discussionmentioning

confidence: 99%

Naringenin Protects against Hypertension by Regulating Lipid Disorder and Oxidative Stress in a Rat Model

Liu

Zhao

Che

et al. 2022

Kidney Blood Press Res

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Background: Naringenin, a natural resource-derived flavanone, exhibits a plethora of pharmacological properties. The present study aimed to investigate the effects of Naringenin on obesity-associated hypertension and its underlying mechanism. Methods: Obesity-associated hypertension rat model was established with a high-fat diet (HFD) and was administrated with Naringenin (25, 50, 100 mg/kg). Body and fat weight were recorded and blood pressure was measured. Serum lipid parameters (cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides), oxidative stress biomarkers (malondialdehyde (MDA), superoxide dismutase (SOD), nitrite oxide (NO), and glutathione (GSH)), and adipocytokines (leptin and adiponectin) were determined. The expressions of signal transducer and activator of transcription (STAT) 3 were determined by using Western blotting. Results: Treatment with Naringenin (100 mg/kg) reduced body and fat weight in HFD-induced rats. Besides, treatment with Naringenin (50 and 100 mg/kg) reduced blood pressure and regulated lipid parameters by decreasing cholesterol, triglycerides, and LDL and increasing HDL. Treatment with Naringenin (50 and 100 mg/kg) reduced serum MDA and NO, whereas increased serum SOD and GSH. Furthermore, Treatment with Naringenin (50 and 100 mg/kg) regulated adipocytokines and decreased the phosphorylation of STAT3. Conclusion: Naringenin ameliorates obesity-associated hypertension by regulating lipid disorder and oxidative stress.

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“…The results showed that the key of BXD active ingredients including naringenin, 16 alpha-Hydroxydehydrotrametenolic acid, poricoic acid C, eburicoic acid, and licochalcone B. Naringenin is a flavanone, aglycone of naringin, exhibits a plethora of pharmacological properties. Studies have shown that naringenin exerts antihypertensive effects by attenuating the MCR/ACE/KIM-1 pathway (Oyagbemi et al, 2020). Recently, Liu et al found that naringenin can reduce weight, fat, and blood pressure in obesity-associated hypertension rats, and the mechanism is related to the regulation of lipid disorders and oxidative stress (Liu et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Banxia baizhu tianma decoction, a Chinese herbal formula, for hypertension: Integrating meta-analysis and network pharmacology

Lin

Wang

et al. 2022

Front. Pharmacol.

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Hypertension is a major cardiovascular risk factor, which seriously affects the quality of life of patients. Banxia Baizhu Tianma Decoction (BXD) is a Chinese herbal formula that is widely used to treat hypertension in China. This study aimed to evaluate the efficacy and potential mechanism of BXD for hypertension by meta-analysis and network pharmacology. Meta-analysis was performed to explore the efficacy and safety of BXD combined with conventional treatment for hypertension. Network pharmacology was used to explore the molecular mechanism of BXD in antihypertension. A total of 23 studies involving 2,041 patients were included. Meta-analysis indicated that compared with conventional treatment, combined BXD treatment was beneficial to improve clinical efficacy rate, blood pressure, blood lipids, homocysteine, endothelial function, inflammation, and traditional Chinese medicine symptom score. In addition, meta-analysis indicated that BXD is safe and has no obvious adverse reactions. Network pharmacology showed that the antihypertensive targets of BXD may be AKT1, NOS3, ACE, and PPARG. The antihypertensive active ingredients of BXD may be naringenin, poricoic acid C, eburicoic acid, and licochalcone B. Due to the poor methodological quality of the Chinese studies and the small sample size of most, the analysis of this study may have been affected by bias. Therefore, the efficacy and safety of BXD for hypertension still need to be further verified by high-quality clinical studies.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42022353666

show abstract

Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway

Cited by 22 publications

References 81 publications

Flavonoids and cardiovascular risk factors: a review

Flavonoids and cardiovascular risk factors: a review

Naringenin Protects against Hypertension by Regulating Lipid Disorder and Oxidative Stress in a Rat Model

Banxia baizhu tianma decoction, a Chinese herbal formula, for hypertension: Integrating meta-analysis and network pharmacology

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