Antihypertensive effect of nuatigenin-3-O-β-chacotriose from Solanum sisymbriifolium Lam. (Solanaceae) (ñuatî pytâ) in experimentally hypertensive (ARH+DOCA) rats under chronic administration

Ibarrola, D.A.; Hellión-Ibarrola, M.C.; Montalbetti, Y.; Heinichen, O.; Campuzano, M.; Kennedy, María L.; Alvarenga, Nelson; Ferro, Esteban; Dolz-Vargas, Julio Humberto; Momose, Yasunori

doi:10.1016/j.phymed.2011.01.012

Cited by 17 publications

(6 citation statements)

References 19 publications

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“…Nuatigenosido ( 15 ) from the roots of S. sisymbriifolium presented anti-hypertensive effect in experimental hypertensive rats [291]. Dioscin ( 19 ) showed antimelanogenesis effect on α-melanocyte stimulating hormone (α-MSH)induced melanogenesis in B16 murine melanoma cells.…”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

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The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

103

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

“…Solanum saponins were reported to have various bioactivies, e.g. cytotoxic [257], anticancer [316, 317, 392], hepatoprotective [242, 247], antihypertensive [289, 291], antimelanogenesis [211], antifungal [113, 114, 117], anti-inflammatory [331, 392, 448] anticonvulsant [305] and antiviral [257].…”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

103

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“…Saponin S2 was identified as nuatigenoside, which was first isolated from the bulbs of Triteleia lactea ( 22 ) and later from the roots of S. sisymbriifolium ( 14 ). Saponin S2 has shown antihypertensive activity ( 35 ) and inhibitory activity against cyclic AMP phosphodiesterase ( 22 ), but to the best of our knowledge, this is the first study describing its antiviral activity. The four distinct serotypes of DENV are antigenically related, but immunologically distinct.…”

Section: Discussionmentioning

confidence: 99%

Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus

Figueiredo

Coronel

Trabuco

et al. 2021

Braz J Med Biol Res

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Dengue is the most important arthropod-borne viral disease worldwide. Infection with any of the four dengue virus (DENV) serotypes can be asymptomatic or lead to disease with clinical symptoms ranging from undifferentiated and self-limiting fever to severe dengue disease, which can be fatal in some cases. Currently, no specific antiviral compound is available for treating DENV. The aim of this study was to identify compounds in plants from Paraguayan folk medicine with inhibitory effects against DENV. We found high virucidal activity (50% maximal effective concentration (EC 50 ) value of 24.97 mg/mL) against DENV-2 in the ethanolic extract of the roots of Solanum sisymbriifolium Lam. (Solanaceae) without an evident cytotoxic effect on Vero E6 cells. Three saponins isolated from the root extract showed virucidal effects (EC 50 values ranging from 24.9 to 35.1 mg/mL) against DENV-2. Additionally, the saponins showed inhibitory activity against yellow fever virus (EC 50 values ranging from 126 to 302.6 mg/mL), the prototype virus of the Flavivirus genus, suggesting that they may also be effective against other members of this genus. Consequently, these saponins may be lead compounds for the development of antiviral agents.

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“…Solanum sisymbriifolium (wild tomato) and Solanum paludosum Moric (SpM) exhibit hypotensive effects. Root extract of wild tomatoes is reported to decrease BP level in normotensive and hypertensive rats (Ibarrola et al, 1996 , 2000 , 2011 ). SpM (75 μg/ml) exhibits vasodilatory activities in rat aortic rings by a NO-dependent pathway (Monteiro et al, 2012 ; Table 2 ).…”

Section: Herbs and Spices Less Commonly Used For Treatment Of Hypertementioning

confidence: 99%

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

2016

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Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to treat and manage cardiovascular disease (CVD) is on the rise. This is the second part of our comprehensive review where we discuss the mechanisms of plants and herbs used for the treatment and management of high blood pressure. Similar to the first part, PubMed and ScienceDirect databases were utilized, and the following keywords and phrases were used as inclusion criteria: hypertension, high blood pressure, herbal medicine, complementary and alternative medicine, endothelial cells, nitric oxide (NO), vascular smooth muscle cell (VSMC) proliferation, hydrogen sulfide, nuclear factor kappa-B (NF-κB), oxidative stress, and epigenetics/epigenomics. Each of the aforementioned keywords was co-joined with plant or herb in question, and where possible with its constituent molecule(s). This part deals in particular with plants that are used, albeit less frequently, for the treatment and management of hypertension. We then discuss the interplay between herbs/prescription drugs and herbs/epigenetics in the context of this disease. The review then concludes with a recommendation for more rigorous, well-developed clinical trials to concretely determine the beneficial impact of herbs and plants on hypertension and a disease-free living.

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Antihypertensive effect of nuatigenin-3-O-β-chacotriose from Solanum sisymbriifolium Lam. (Solanaceae) (ñuatî pytâ) in experimentally hypertensive (ARH+DOCA) rats under chronic administration

Cited by 17 publications

References 19 publications

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus

Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II

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