Antihypertensive Effect of an Extract of<i>Passiflora edulis</i>Rind in Spontaneously Hypertensive Rats

Ichimura, Toshiaki; Yamanaka, Akiko; Ichiba, Toshio; Toyokawa, Tetsuya; Kamada, Yasuhiro; Tamamura, Takako; Maruyama, Susumu

doi:10.1271/bbb.70.718

Cited by 92 publications

(58 citation statements)

References 10 publications

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“…In humans, the use of natural products such as Erytrina mulungu (500 mg) acute form Matricaria recutita (chamomile; 220 mg) for 8 weeks and oficinallis L. Melissa (lemon balm, 600 mg) for two weeks demonstrated anxiolytic effects by Corah scales modified, Hamilton Anxiety Scale and the Free Rating Scale for Anxiety, respectively [23,24,25].…”

Section: Discussionmentioning

confidence: 99%

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Silva¹,

Costa²,

Alves³

et al. 2017

int arch med

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Object: This study aimed to investigate the effects of Passiflora incarnata L. on anxiety in humans. Method:The individuals were randomly assigned to one of the following groups: Placebo or experimental, n =30, single dose, as well as Placebo or Experimental, n =15, multiple dose. The experimental human anxiety was induced by simulated public speaking test in the following phases: Basal (B), stressful (A), speech 1 (S1), speech 2 (S2) and Final (F). We evaluated the Systolic Blood Pressure (SBP), and Diastolic (DBP), Heart Rate (HR), Electrical Conductance of Skin and extremities temperature (ET) and filled The state-trait anxiety inventory (STAI S e T).Results: During the single dose, the HR was reduced at the end of the speech (86±2.0 to 74±3.0 bpm) the experimental group compared to the placebo group (p<0.05); the STAI-S did not change. In the delineation of multiple doses, SBP was reduced, in mmHg, in the experimental group compared to the placebo group during all phases. Experimental: 106±1.0 (B), 111±1.0 (A), 121±2.0 (S1), 115±3 (S2), 104±2.0 (F) IntroductionAnxiety disorders reach over 25% prevalence, including the fear of public speaking [1]. Anxiety comprises emotional and behavioral factors through fear manifestation, insecurity, apprehensive anticipation, catastrophic thinking, increase in wakefulness or alert period and physiological, as activation of the hypothalamic-pituitary-adrenal (HPA) axis, leading neurovegetative symptoms such as insomnia, tachycardia, pallor, increased perspiration, muscle tension, trembling, dizziness, intestinal disorders, among others [2].The impact of anxiety on the individuals's health covers changes in blood pressure, heart rate and an increased risk of cardiovascular diseases such as coronary heart disease (risk tripled) and cerebrovascular [3].Therefore, researchers have invested in as natural forms taken to treat or ameliorate the symptoms of anxiety, such as the use of herbs. Plants that are most studied with anxiolytic potential are Kawa, the St. John's Wort and Passiflora spp. [4][5][6][7]. The Passiflora extract has been used in many researches, presenting in their chemical constitution polyphenols, polyunsaturated fatty acids, fiber and other substances, such as passiflorin, one indole alkaloid, being the last one associated with anxiolytic effects [3].The effects of Passiflora incarnata L on anxiety was previously assessed in animals [8,4] and in humans [9-10] with satisfactory results [7]. Epidemiological studies have shown that the fear of public speaking is one of the biggest phobias that affect people, being highly prevalent among students [11].The study proposal was to evaluate symptoms of anxiety of public speaking, under a single dose and multiple doses through the simulated public speaking (SPS) test through the intervention with the encapsulated dry extract of the whole plant Passiflora incarnata L. Materials and MethodsSubjects A study population consisted of university students, adults, healthy, between 24 and 31 years, of both sexes, wer...

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Section: Discussionmentioning

confidence: 99%

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Silva¹,

Costa²,

Alves³

et al. 2017

int arch med

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“…P. edulis Sims extract, for example, decreases blood pressure in spontaneously hypertensive rats (SHRs) and contains metabolites like luteolin, luteolin-6-C-glucoside and gammaaminobutyric acid (GABA) from the rind (19), phenolic compounds, ascorbic acid, carotenoids and flavonoids from the fruit pulp (20) and edulilic acid and anthocyanin from their leaves (21). Other Passiflora species studied are: P. nepalensis Walp (22), P. foetida Linn (23) and P. incarnate Linn (24).…”

Section: Introductionmentioning

confidence: 99%

Passiflora quadrangularis L. PREVENTS EXPERIMENTAL HYPERTENSION AND VASCULAR REMODELLING IN RATS EXPOSED TO NITRIC OXIDE DEFICIT

Bareño

Puebla

Guerra

et al. 2017

Vitae

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Background: Passiflora quadrangularis L. is among the species used in Colombian folk medicine for hypertension, but until now it has not been studied in experimental models. Objectives: To assess the capacity of P. quadrangularis L. EtOH extract to prevent the hypertension and vascular remodelling induced by nitric oxide (NO) deficit in Wistar rats. Methods: The nitric oxide (NO) synthase inhibitor L-NAME (10 mg/kg, i.p (intraperitoneal), every 48h) was administered for seven weeks to the following groups of rats: P. quadrangularis L.75, 150 and 300 mg/kg/d, p.o. (oral route); enalapril as reference agent, 10 mg/kg/d, p.o. and vehicle as control (mixture of propylene glycol 10%, glycerine 10% and polysorbate 2%). Arterial blood pressure (BP) and heart rate (HR) were measured twice a week. After sacrifice, the aortic rings were isolated, contraction was triggered with phenylephrine (PE 10 -6 M) and then the relaxant response achieved with cumulative concentrations of acetylcholine (ACh, 10 -10 -10 -5 M) or sodium nitroprusside (SNP, 10 -10 -10 -5 M) was assessed. Histopathologic measures of thickness/lumen ratio from both the left ventricle and aorta walls, as well as phytochemical screening, were also performed. Results: As for enalapril, all doses of P. quadrangularis L. prevented the hypertension induced by L-NAME (122±1.2 versus 155±1.3 mmHg at seventh week). P. quadrangularis L. significantly increased the relaxant effect induced by ACh in isolated aorta and decreased the thickness/lumen ratio of aorta wall specimens. Conclusions: P. quadrangularis L. prevents experimental hypertension induced in rats with nitric oxide deficits improving the endothelium vasodilatation response and protecting against vascular remodelling.

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“…The herbs and their extracts, which are polyphenol rich, have been shown to have effect against hypertension (Ichimura et al, 2006;Oboh et al, 2012), cancer (Ayoub et al, 2010;Hafeez et al, 2006;Martin et al, 2013), Alzheimer's disease (Wang et al, 2008) and cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Poly-phenolic fraction of <i>Chrysophyllum cainito</i> extract induces cell death in osteosarcoma cells

Lin

Yan

et al. 2015

Bangladesh J Pharmacol

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MaterialsGallic acid, vincristine, propidium iodide, formalin, crystal violet, crystal violet, fetal bovine serum (FBS), chloroquine, penicillin, streptomycin, 2', 7'-dichlorofluorescein diacetate, Folin-Ciocalteu's phenol reagent and annexin V-FITC apoptosis detection kit were purchased from Sigma-Aldrich. Remaining chemicals and reagents utilized in this research work were of analytical grade and were used as such. AbstractOsteosarcoma shows resistance to chemotherapy and many side effects. The ethyl acetate fraction of ethanolic extract of Chrysophyllum cainito was taken in the present work. The extract was characterized for its phenolic content, antioxidant capacity (ferric reducing antioxidant power and 2,2-diphenyl-1-picrylhydrazyl assays), ability to form reactive oxygen species and annexin V assay. The extract contained phenolic content of 30.1 ± 0.2 mg GAE/g extract. Ferric reducing antioxidant power assay and DPPH assay showed 213.2 ± 12.4 mM Fe 2+ equivalent per gram extract and 85.6 ± 4.9 TE/g respectively. For production of reactive oxygen species in the osteosarcoma cells, extract at 50 µg GAE/mL concentration was statistically equivalent to 100 µM H2O2. EC50 of extract was calculated to be 133 µg GAE/mL in cell viability studies. Article Info

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Antihypertensive Effect of an Extract ofPassiflora edulisRind in Spontaneously Hypertensive Rats

Cited by 92 publications

References 10 publications

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Passiflora quadrangularis L. PREVENTS EXPERIMENTAL HYPERTENSION AND VASCULAR REMODELLING IN RATS EXPOSED TO NITRIC OXIDE DEFICIT

Poly-phenolic fraction of <i>Chrysophyllum cainito</i> extract induces cell death in osteosarcoma cells

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