Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa

Mojiminiyi, F.B.O.; Dikko, M.; Muhammad, Bala Yauri; Ojobor, Peter; Ajagbonna, O. P.; Okolo, R. U.; Igbokwe, U V; Mojiminiyi, U.E.; Fagbemi, M.A.; Bello, Shaibu Oricha; Anga, T.J.

doi:10.1016/j.fitote.2007.02.011

Cited by 81 publications

(59 citation statements)

References 14 publications

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“…This is in agreement with several other reports (Mojiminiyi et al, 2000;Orisakwe et al, 2004;Ojokoh, 2006;Iyare and Adegoke, 2008a,b,c).…”

Section: Discussionsupporting

confidence: 94%

Mechanism of the delayed puberty onset in offspring of rats that consumed aqueous extract of hibiscus sabdariffa during pregnancy

Iyare¹,

Adegoke²

2010

Nig. J. Phys Sci

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Summary: Consumption of extracts of Hibiscus sabdariffa (family: malvaceae) during pregnancy has been shown to cause maternal malnutrition which has been linked to various adverse conditions like increased postnatal weight gain, delayed puberty onset and elevated body weight and body mass index at onset of puberty in the female offspring. The present study was designed to investigate the possible mechanism underlying this. Eighteen in-bred pregnant Sprague-Dawley rats were on day 1 of pregnancy, randomly divided into three groups of six animals each. Group A (control) was given tap water to drink. Group B was given 0.6g extract/100ml while Group C was given 1.8g extract/100ml as their drinking solution. All groups received normal rat chow and their drinking solution ad libitum. Fluid and food intake and dam weights were measured daily throughout pregnancy. On gestational day 18, blood sample was withdrawn from each rat for estimation of plasma Na ion and corticosterone levels. On the day of delivery, the solutions of the extracts of Hibiscus sabdariffa were withdrawn and replaced with tap water. After 21 days, the pups were weaned to tap water and food ad libitum. Pups weight and age and body mass index at onset of puberty were measured. The results of the present study showed that the increased postnatal weight gain, delayed puberty onset and elevated body mass index at onset of puberty in the offspring of rats that consumed HS during pregnancy was associated with elevated maternal plasma Na ion and corticosterone levels during pregnancy.

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“…This is in agreement with several other reports (Mojiminiyi et al, 2000;Orisakwe et al, 2004;Ojokoh, 2006;Iyare and Adegoke, 2008a,b,c).…”

Section: Discussionsupporting

confidence: 94%

Mechanism of the delayed puberty onset in offspring of rats that consumed aqueous extract of hibiscus sabdariffa during pregnancy

Iyare¹,

Adegoke²

2010

Nig. J. Phys Sci

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“…Aqueous extract of HS has also been shown to be rich in Na + (Adigun et al, 2006). This, coupled with the reported diuretic effect of HS (Mojiminiyi et al, 2000) may have caused the plasma hypernatraemia observed by Mojiminiyi and Co-workers (2000). The water deprivation in these dams and the accompanying plasma hypernatraemia (osmotic stress) may have caused dehydration-anorexia (Ross and Desai, 2005) with the resultant decrease in food intake (nutrient stress).…”

Section: Discussionmentioning

confidence: 53%

Maternal consumption of an aqueous extract of hibiscus Sabdariffa during lactation accelerates postnatal weight and delays onset of puberty in female offspring

Iyare¹,

Adegoke²

2010

Nig. J. Phys Sci

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Summary:The present study was designed to investigate whether maternal consumption of aqueous extract of Hibiscus sabdariffa (HS) during lactation will affect the postnatal growth and onset of puberty in the female offspring. Eighteen in-bred virgin female Sprague-Dawley rats aged between 10-12 weeks and weighing 125 ± 5.5g (mean ± SEM) with two consecutive regular 4-day estrus cycles were randomly assigned to one of three groups of 6rats/group. One group had tap water (Control); another had 0.6g/100ml while the third group had 1.8g/100ml in their drinking water throughout lactation (21 days). Results showed that HS consumption during lactation significantly (P<0.05) decreased maternal fluid and food intake, increased postnatal weight gain and delays the onset of puberty in the female offspring.

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“…HS is composed of alkaloids, L-ascorbic acid, anisaldehyde, anthocyanin, β-carotene, β-sitosterol, citric acid, cyanidin-3-rutinoside, delphinidin, galactose, gossypetin, hibiscetin, mucopolysaccharide, pectin, protocatechuic acid, polysaccharide, quercetin, and stearic acid. 9 Currently, the dried calyx extracts of HS are commercially available in the form of granules or tea and sold as health food products that are diuretic, hypocholesterolemic, 8 antihypertensive, 10,11 and an antioxidant. 9 Most importantly, HS was recently demonstrated to be effective in attenuating the progression of kidney injury in streptozocin-induced diabetic nephropathy in rats through its antilipidemic and antioxidant properties.…”

Section: Discussionmentioning

confidence: 99%

“…For example, HS has been shown to have antibacterial, hypocholesterolemic, 8 antioxidant, 9 and vasodilatory activities. 10,11 In addition, HS was able to lower high blood pressure in hypertensive rats 11 and patients. 5 Several activities such as nitric oxide inhibitor, 12 calcium channel blocker, 13 and angiotensin-converting enzyme inhibitor 14 were known to explain the hypotensive effects of HS.…”

Section: Introductionmentioning

confidence: 95%

Hibiscus SabdariffaLinnaeus Aqueous Extracts Attenuate the Progression of Renal Injury in 5/6 Nephrectomy Rats

et al. 2012

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Hibiscus sabdariffa Linn. (HS) is a tropical wild plant with antioxidant, antibacterial, antihypertensive, and lipid-lowering properties. In several animal models, HS aqueous extracts reduced the severity of the multi-organ injuries such as hypertension and diabetic nephropathy. One of the multiorgan injuries is chronic kidney disease (CKD), which results from the loss of nephron function. HS was used in a 5/6 nephrectomy (5/6 Nx) rat model to determine if it could attenuate the progression of CKD. HS (250 mg/kg/day) or placebo was orally administered to 5/6 Nx male Sprague-Dawley rats. The NxþHS group had fewer renal injuries as measured by blood urea nitrogen, serum creatinine, creatinine clearance, and renal pathology when compared with the Nx group. In order to determine which property of HS, either vasodilatory and/or antioxidant, was important in attenuating the progression of CKD, systolic blood pressure (SBP) and serum levels of malondialdehyde (MDA) were assessed. In the NxþHS group, the SBP and the serum levels of MDA were significantly lower at Week 7. In conclusion, through either antihypertensive and/or antioxidant properties, HS was able to attenuate the progression of renal injury after 5/6 Nx. Hence, HS should be considered as one of the new, promising drugs that can be used to attenuate the progression of CKD.

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Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa

Cited by 81 publications

References 14 publications

Mechanism of the delayed puberty onset in offspring of rats that consumed aqueous extract of hibiscus sabdariffa during pregnancy

Mechanism of the delayed puberty onset in offspring of rats that consumed aqueous extract of hibiscus sabdariffa during pregnancy

Maternal consumption of an aqueous extract of hibiscus Sabdariffa during lactation accelerates postnatal weight and delays onset of puberty in female offspring

Hibiscus SabdariffaLinnaeus Aqueous Extracts Attenuate the Progression of Renal Injury in 5/6 Nephrectomy Rats

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