Antihypertensive Effect and Side‐effects of Bendroflumethiazide and Propranolol

Abstract

The antihypertensive effect and sideeffects during 12 months' treatment with bendrotlumethiazide and propranolol have been compared in two randomly selected, equally large groups (n= 53) of previously untreated male hypertensives. Systolic BP above 170 or diastolic BP above 105 mmHg on two occasions were defined as hypertension. The

Elevated Serum Uric Acid Levels During Treatment With Antihypertensive Drugs

“…In the clinical trial with diuretics and D-blockers mentioned above it was noted that also n-blockers significantly increased the serum uric acid levels compared to placebo (Figure 3) (Bengtsson 1972). These results have been confirmed later (Bengtsson 1976, Berglund et al 1976 as shown in Table 11. The increase in serum uric acid levels during treatment with B-blockers has been shown to be of statistical significance but is modest and high levels have seldom been noted.…”

Atenolol versus Bendroflumethiazlde in Middle‐aged and Elderly Hypertensives

“…The increase in serum uric acid associated with both drugs did not result in any cases of clinical gout. This observation is in agreement with the results of other studies (28,29). The frequency of side-effects during both treatments was low, all side-effects were mild and in accordance with previous experience with atenolol and bendroflumethiazide.…”

Lowering and Raising Serum Urate Levels: Off-Label Effects of Commonly Used Medications

“…b-Blockers. The b-blockers propranolol, 89,90 atenolol, 69 metoprolol, 70,91 and sotalol 91 have all been found to modestly increase sU levels. 92 In a trial of hypertensive patients treated with atenolol (50-100 mg once daily; n¼67) for 12 weeks, the mean sU level increased from 5.2 mg/dL to 5.7 mg/ dL.…”