Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancy

Xu, Bei; Makris, Angela; Thornton, Charlene; Ogle, Robert; Horvath, John S.; Hennessy, Annemarie

doi:10.1097/01.hjh.0000222762.84605.03

Cited by 41 publications

(39 citation statements)

References 37 publications

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“…A few years later, Pascuali et al [53] performed a study in adult obese and normalweight male subjects and found that the suppression of insulin levels by diazoxide reduced testosterone and increased SHBG blood concentrations. These two studies support the concept that insulin is a regulator of SHBG production; however, they did not take into account the anti-inflammatory actions of diazoxide [54][55][56][57], which could affect the interpretation of the reported results.…”

Section: Shbg Expression and The Role Of Insulinmentioning

confidence: 69%

Novel insights in SHBG regulation and clinical implications

Simó

Sáez-López

Barbosa-Desongles

et al. 2015

Trends in Endocrinology & Metabolism

230

175

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Section: Shbg Expression and The Role Of Insulinmentioning

confidence: 69%

Novel insights in SHBG regulation and clinical implications

Simó

Sáez-López

Barbosa-Desongles

et al. 2015

Trends in Endocrinology & Metabolism

230

175

View full text Add to dashboard Cite

“…Similarly, Xu et al showed reduction in TNF α, IL-10 and IL-6 in pre-eclamptic placentas of women treated with increasing doses of clonidine [18]. However, this same group also reported no change in TNF α production from placentas and peripheral blood mononuclear cells of healthy women treated with clonidine [19]. To the contrary, UK-14304, a α2 agonist augmented lipopolysaccharide stimulated TNF α production from murine macrophages in vitro [20].…”

Section: Discussionmentioning

confidence: 96%

Relationship between Growth Hormone and Cytokines in Short Children Undergoing Growth Hormone Stimulation Testing

Tafuri¹,

Dixon²,

Markarian³

et al. 2015

IJCM

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Background: The relationship between growth hormone (GH) and cytokines remains unclear. Several studies have suggested that GH increases tumor necrosis factor (TNF)-α production in both children and adults. However, a number of studies have demonstrated a negative correlation between GH and TNF α. The aim of this study is to explore the relationship between endogenous GH secretion and certain pro and anti-inflammatory cytokines in short children undergoing GH stimulation testing for evaluation for GH deficiency. Methods: Plasma growth hormone, TNF α, CRP, IL-6, IL1-β, IL-4 and IL-10 levels are obtained at baseline and every 30 minutes for 150 minutes following two provocative agents (clonidine, and either arginine or glucagon). Results: Among the 23 children, 7 are found to be GH deficient. No significant differences in baseline TNF α levels are found between GH deficient and GH sufficient children. No correlation is identified between TNF α levels and GH levels during stimulation testing. Furthermore, no relationship is found between GH and pro-inflammatory cytokines or GH and anti-inflammatory cytokines. Conclusion: Our results do not demonstrate an acute relationship between endogenous GH secretion and the cytokines examined.

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“…Catecholamines are potent modulators of cytokine production, through triggering of adrenergic receptors. Recently, the α 2 -ADR agonist, clonidine, was reported to stimulate the production of antiinflammatory IL-12 in the macrophages of mice [39], and to reduce the production of pro-inflammatory IL-1β and IL-6 in the injured nerves of rats [40] and the production of IL-6 and TNF-α in human peripheral blood mononuclear cells [41]. These data suggest that clonidine may directly or indirectly affect the production of anti-and proinflammatory cytokines in the RPE.…”

Section: Discussionmentioning

confidence: 99%