Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive

Hakkou, Zineb; Maciuk, Alexandre; Leblais, Véronique; Bouanani, Nour Elhouda; Mekhfi, Hassane; Bnouham, Mohammed; Aziz, Mohammed; Ziyyat, Abderrahime; Rauf, Abdur; Hadda, Taïbi Ben; Shaheen, Usama; Patel, Seema; Fischmeister, Rodolphe; Legssyer, Abdelkhaleq

doi:10.1016/j.biopha.2017.06.015

Cited by 53 publications

(18 citation statements)

References 32 publications

(32 reference statements)

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“…Cynarin (30) Antimicrobial [125], hepatoprotective [126], antihypertensive, vasodilator [127], choleretic [128].…”

Section: Secondary Metabolite Biological Activitiesmentioning

confidence: 99%

“…Chlorogenic Acid (31) Antimicrobial [125], hepatoprotective [126], antihypertensive, vasodilator [127], antitumor [129], anti-inflammatory [130], improves late diabetes [131], protects against cholestatic liver injury [132], neuroprotective [133], antiviral activity against influenza A (H1N1/H3N2) virus [134], anti-diabetic and anti-lipidemic [135], inhibits hepatocellular carcinoma [136], anxiolytic and antioxidant [137], antihyperalgesic [138], cardioprotective [139], neuroprotective and cognitive improvement [140], improves hepatic steatosis and insulin resistance [141], alleviates obesity and modulates gut microbiota [142], ameliorates ulcerative colitis [143], inhibits glioblastoma growth [144], induces 4T1 breast cancer tumor's apoptosis [145], strong matrix metalloproteinase-9 inhibitor [146].…”

Section: Secondary Metabolite Biological Activitiesmentioning

confidence: 99%

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Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Miski

2021

Plants

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Silphion was an ancient medicinal gum-resin; most likely obtained from a Ferula species growing in the Cyrene region of Libya ca. 2500 years ago. Due to its therapeutic properties and culinary value, silphion became the main economic commodity of the Cyrene region. It is generally believed that the source of silphion became extinct in the first century AD. However, there are a few references in the literature about the cultivated silphion plant and its existence up to the fifth century. Recently, a rare and endemic Ferula species that produces a pleasant-smelling gum-resin was found in three locations near formerly Greek villages in Anatolia. Morphologic features of this species closely resemble silphion, as it appears in the numismatic figures of antique Cyrenaic coins, and conform to descriptions by ancient authors. Initial chemical and pharmacological investigations of this species have confirmed the medicinal and spice-like quality of its gum-resin supporting a connection with the long-lost silphion. A preliminary conservation study has been initiated at the growth site of this rare endemic Ferula species. The results of this study and their implications on the regional extinction event, and future development of this species will be discussed.

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“…Cynarin (30) Antimicrobial [125], hepatoprotective [126], antihypertensive, vasodilator [127], choleretic [128].…”

Section: Secondary Metabolite Biological Activitiesmentioning

confidence: 99%

Section: Secondary Metabolite Biological Activitiesmentioning

confidence: 99%

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Miski

2021

Plants

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“…Epidemiological studies demonstrated that chlorogenic acid (CGA), a type of dietary polyphenol present in high quantities in plants and constituting the main active ingredient in many fruits, vegetables, and plants [16, 17], possesses numerous pharmacological activities, including those associated with antioxidative [18], anticancer [19–21], hypolipidemic [22], antihypertensive [23], anti-inflammatory [24], and hypoglycemic effects. Moreover, studies reported effects related to anti-insulin resistance and obesity [25], and protection against plant pathogenic fungi [26], as well as antimicrobial effects [27], inhibition of bile-duct ligation-induced liver injury [28], and attenuation of lipopolysaccharide-induced acute kidney injury [29].…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Functions as a Novel Agonist of PPARγ2 during the Differentiation of Mouse 3T3-L1 Preadipocytes

Peng

Pang

Zhu

et al. 2018

BioMed Research International

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Rosiglitazone (RG) is a well-known activator of peroxisome proliferator-activated receptor-gamma (PPARγ) and used to treat hyperglycemia and type 2 diabetes; however, its clinical application has been confounded by adverse side effects. Here, we assessed the roles of chlorogenic acid (CGA), a phenolic secondary metabolite found in many fruits and vegetables, on the differentiation and lipolysis of mouse 3T3-L1 preadipocytes. The results showed that CGA promoted differentiation in vitro according to oil red O staining and quantitative polymerase chain reaction assays. As a potential molecular mechanism, CGA downregulated mRNA levels of the adipocyte differentiation-inhibitor gene Pref1 and upregulated those of major adipogenic transcriptional factors (Cebpb and Srebp1). Additionally, CGA upregulated the expression of the differentiation-related transcriptional factor PPARγ2 at both the mRNA and protein levels. However, following CGA intervention, the accumulation of intracellular triacylglycerides following preadipocyte differentiation was significantly lower than that in the RG group. Consistent with this, our data indicated that CGA treatment significantly upregulated the expression of lipogenic pathway-related genes Plin and Srebp1 during the differentiation stage, although the influence of CGA was weaker than that of RG. Notably, CGA upregulated the expression of the lipolysis-related gene Hsl, whereas it did not increase the expression of the lipid synthesis-related gene Dgat1. These results demonstrated that CGA might function as a potential PPARγ agonist similar to RG; however, the impact of CGA on lipolysis in 3T3-L1 preadipocytes differed from that of RG.

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“…Chlorogenic acids are another extensively studied group as nutraceuticals, which we detected in three fruit extracts, including AC, CP-r, and PG. Chlorogenic acid is evident for biological activities of antioxidant, anti-inflammatory, glucose, and lipid metabolism regulation and its beneficial effect on CVD ( 50 , 51 ). For instance, maoberry, an indigenous Thai fruit rich in chlorogenic acid, quercetin, and other phytoantioxidants, exhibited significant antioxidant stress effect in a high-fat diet rat model, leading to the inactivation of pro-inflammatory mediator release (e.g.…”

Section: Discussionmentioning

confidence: 99%

Screening of potential tropical fruits in protecting endothelial dysfunction in vitro

Wattanapitayakul

Kunchana

Jarisarapurin

et al. 2021

Food & Nutrition Research

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Background: High consumption of antioxidant-rich fruits and vegetables reduces the endothelial damage involved in cardiovascular disease pathogenesis. Objective: To evaluate the phytochemical content, antioxidant and scavenging activities (FRAP, ORAC, OH•, HOCl, H2O2, and O2−), endothelial H2O2-cytoprotective effect, nitric oxide (NO) release activation potential, and endothelial wound healing properties of 10 tropical fruits, comprising pineapple, sugar apple, papaya fruit, longan, mangosteen, lychee, langsat, mango, rambutan, and guava. Design: Experimental study. The experiments were conducted in vitro using endothelial cell line EA.hy926. Results: The high performance liquid chromatography (HPLC) phytochemical analysis indicated the presence of gallic acid and quercetin in all fruits, along with the overall absence of ellagic acid. Chlorogenic acid was only detected in three fruits, that is, pineapple, ripe papaya, and guava. The antioxidant and scavenging activities of all fruits were concentration-dependent. Only the H2O2 scavenging activity exhibited broad positive associations with other ROS-scavenging activities. Sugar apple and unripe papaya induced a significant reduction in H2O2-induced cell death in endothelial cells while pineapple, sugar apple, longan, and langsat activated NO release. Discussion: All the studied tropical fruits contained bioactive phytoantioxidants with wide ranges of antioxidant capacity and scavenging activities. The endothelial functional tests were relevant to the screening for fruits that may benefit cardiovascular health. Among the four fruits that promoted endothelial wound closure, only sugar apple and unripe papaya induced cell migration and vascular capillary-like tube formation. Conclusion: Sugar apple and unripe papaya are potential functional fruits that can protect against oxidative cell death and enhance endothelial wound healing.

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Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive

Cited by 53 publications

References 32 publications

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Chlorogenic Acid Functions as a Novel Agonist of PPARγ2 during the Differentiation of Mouse 3T3-L1 Preadipocytes

Screening of potential tropical fruits in protecting endothelial dysfunction in vitro

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