Antihyperlipidemic effects of buckwheat leaf and flower in rats fed a high-fat diet

Lee, Jeong-Sun; Bok, Song Hae; Jeon, Seon-Min; Kim, Hye-Jin; Do, Kyung-Min; Park, Yong-Bok; Choi, Myung‐Sook

doi:10.1016/j.foodchem.2009.06.014

Cited by 29 publications

(14 citation statements)

References 19 publications

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“…Vegetable protein and dietary fiber have been shown to be associated with a lower risk of diabetes mellitus and cardiovascular disease (Anderson et al 2004;Hilleboe 1957). Moreover, GABA, CoQ10, and rutin have antihypertensive effects (Inoue et al 2003;Kumar et al 2009;Lee et al 2010), and CoQ10, rutin, and IP 6 have antihyperlipidemic effects (Jariwalla 1999;Kumar et al 2009;Lee et al 2010). We detected GABA in all PS preparations, with the highest levels found in buckwheat and germinated soybean PSs.…”

Section: Discussionmentioning

confidence: 75%

“…We previously reported that rutin is more abundant in buckwheat sprouts than in seeds (Koyama et al 2011). Moreover, rutin has antihypertensive (Ajay et al 2003) and antihyperlipidemic effects (Lee et al 2010). Finally, myo-inositol-1,2,3,4,5,6-hexakisphosphate (IP 6 ), which exhibits antihyperlipidemic activity (Jariwalla 1999), is a common substance found in spermatophytes and functions as a source of phosphorus in seeds.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

et al. 2015

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Hypertension, hyperlipidemia, and diabetes are important precursors of cardiovascular disease. Here, we evaluated the antihypertensive, antihyperlipidemic, and antidiabetic potential of five types of sprouts in fructose-loaded spontaneously hypertensive rats (SHRs). Powdered sprouts (PSs) were produced from mung bean, broccoli, radish, and buckwheat sprouts and germinated soybeans by lyophilization. The PSs were analyzed for nutritional composition and bioactive agents (γ-aminobutyric acid [GABA], coenzyme Q10 [CoQ10], rutin, and myo-inositol-1,2,3,4,5,6-hexakisphosphate [IP6]) and functionally tested in SHRs given water containing 25 % fructose and diets containing 30 % PS for 46 days. All PSs were nutritionally rich in protein and dietary fiber. CoQ10, GABA/rutin, and GABA/IP6 were abundant in broccoli, buckwheat, and germinated soybean PSs, respectively. Mung bean, broccoli, and buckwheat PSs caused significant reductions in heart rates and/or serum triglycerides. Mung bean PS also significantly reduced serum total cholesterol. These data supported the antihypertensive and antihyperlipidemic potential of mung bean, broccoli, and buckwheat sprouts.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

et al. 2015

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“…Result of Lee et al [32] suggests an effect of oleic acid on infarct volume in ischemic rat brain exerted through the activation of peroxisome proliferator activated receptors.…”

Section: Discussionmentioning

confidence: 97%

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

et al. 2015

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The aim of our study was to stablish the possible alternations in fatty acid composition of brain phospholipids in rats on a standard and high-fat diet supplemented with buckwheat leaf and fl ower mixture (BLF) and subsequent possible benefi cial effects of BLF. Four months old male Wistar rats were randomly divided into fi ve experimental groups fed a standard diet, standard diet supplemented with 5% BLF, high-fat diet, high-fat diet with full-period (13 weeks) of 5% BLF supplementation and high-fat diet with partial-period (7 weeks) of 5% BLF supplementation. Gas-liquid chromatography was performed to analyze the fatty acids in hexane lipid extracts of whole rat brains.Supplementation with BLF did not induce signifi cant changes in fatty acid composition of whole brain phospholipids in rats fed the standard diet. In rats on high-fat diet concomitant (full-period) BLF supplementation increased eicosapentaenoic acid (20:5n-3, EPA), total n-6 and n-6/n-3 ratio, and decreased the percentage of oleic acid (18:1n-9) and estimated activity of Δ-9 desaturase. When BLF application was postponed (partial-period) in the case of developed hyperlipidemia, a decrease of stearic acid (18:0) accompanied with an increased estimated Δ-9 desaturase activity was observed. Regardless of BLF supplementation all high-fat diet-fed groups showed an elevated percentage of linoleic acid (18:2n-6, LA) and a reduced estimated Δ-6 desaturase activity.BLF contributes to the maintenance of stable fatty acid composition of brain phospholipids and supports normal brain function in high-fat diet rats, with more positive effects when BLF was applied before hyperlipidemia developed. This could be the mode of buckwheat health benefi cial effects on the brain.

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“…*p50.005 compared with the group N. #p50.005 compared with the group C. N, normal; C, control; HE, hydroalcoholic extract (150, 300, and 600 mg/kg); QRT, quercetrin; SIMV, simvastatin. *p50.005, compared with group N; #p50.0001 compared with group C; &p50.005, compared with group C. DOI: 10.3109/13880209.2014.989622 Hypercholesterolemia and elevated levels of LDL-C are the major risk factors involved in the pathogenesis of cardiovascular diseases, including atherosclerosis (Dai et al, 2013;Lee et al, 2010). The atherogenic index, defined as the TC/HDL-C ratio, has been considered as an indicator of the risk of atherosclerosis development (Silva, 2002;Xia et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…High plasma levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and triacylglycerides (TG), along with oxidative stress and reductions in high-density lipoprotein (HDL-C) levels, are associated with an increased risk of cardiovascular diseases (Dai et al, 2013;Lee et al, 2010). Many studies have shown that elevated plasma cholesterol concentrations can cause coronary atherosclerosis (Park & Velasquez, 2012) and that this effect is associated with heart disease, stroke, and death in both developed and developing countries (Raida et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Hypolipidemic effects ofSolidago chilensishydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

Junior¹,

Piato²,

Conterato³

et al. 2015

Pharmaceutical Biology

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(2015) Hypolipidemic effects of Solidagochilensis hydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats, Pharmaceutical Biology, 53:10, 1488-1495, DOI: 10.3109/13880209.2014 Objective: This study evaluates the hypolipidemic and antioxidant effects of hydroalcoholic extract (HE) and quercetrin from S. chilensis aerial parts in cholesterol-fed rats. Materials and methods: The HE was analyzed by high-performance liquid chromatography, followed by quercetrin isolation. Hypercholesterolemic rats (1% cholesterol and 0.5% cholic acid for 15 d) were treated with HE (150, 300, and 600 mg/kg p.o.; n ¼ 6), simvastatin (4 mg/kg p.o.; n ¼ 6), or quercetrin (10 mg/kg p.o.; n ¼ 6) once a day for 30 d. During this period, a highcholesterol diet was maintained until the 30th day of treatment.Results: Rats treated with HE (150, 300, and 600 mg/kg) and quercetrin showed decreased serum levels of total cholesterol (À19.9, À27.5, À31.0, and À39.4%), lipoprotein-cholesterol (À36.0, À37.5, À43.3, and À59.4%), and triacylglycerides (À15.6, À23.5, À29.8, and À27.2%) when compared with the control group similar to simvastatin. Moreover, treatment with HE and quercetrin decreased hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity (35.1% on average) and increased fecal cholesterol levels (38.2% on average). Discussion and conclusions: Our results suggest that hypolipidemic effects of HE are associated with it modulating the activity of HMG-CoA reductase and its interference in the reabsorption and/or excretion of intestinal lipids. Solidago chilensis and its main constituent, quercetrin, may thus be effective as cholesterol-lowering agents and in preventing atherosclerosis.

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Antihyperlipidemic effects of buckwheat leaf and flower in rats fed a high-fat diet

Cited by 29 publications

References 19 publications

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

Hypolipidemic effects ofSolidago chilensishydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

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