Antihyperlipidemic Effect of Flavonoids from Pterocarpus marsupium

Abstract

Serum lipid levels in rats with hyperlipidemia induced by diet as well as by Triton were determined after oral administration of EtOAc extract of Pterocarpus marsupium heartwood and its flavonoid constituents, marsupsin [1], pterosupin [2], and liquiritigenin [3]. Administration of EtOAc extract for 14 consecutive days produced a significant reduction of serum triglyceride, total cholesterol, and LDL- and VLDL-cholesterol levels without any significant effect on the level of HDL-cholesterol. Liquiritigenin and pterosupin were able to effect a significant fall in serum cholesterol, LDL-cholesterol, and atherogenic index, pterosupin being additionally effective in lowering serum triglyceride.

Antihyperlipidaemic Efficacy of Trachyspermum ammi in Albino Rabbits

“…There is an inverse relationship between plasma HDL-cholesterol level and coronary heart disease (Jahromi et al 1993;Sharma et al 2003). Moreover, apo-B-containing lipoprotein fractions are thought to be responsible for cholesterol deposition in atherosclerotic plaques (Choi 1991).…”

Antiatherogenic Properties of Naringenin, a Citrus Flavonoid

“…While the majority of research has focused on the antioxidant roles of flavonoids, a number of reports have suggested that these compounds may also influence atherogenesis through an effect on lipid and lipoprotein metabolism (4,8,10,14,15,51,88,94,96). Investigation of naturally occurring compounds as regulators of triglyceride and cholesterol metabolism has particular therapeutic importance, as evidenced by the discovery of the first HMG-CoA reductase inhibitors derived from fungal fermentation products, which are now widely used for the treatment of hyperlipidemia.…”

A Review of antihyperlipidemic effect of synthetic phenolic compounds

“…Extract was administered for 14 consecutive days that effectively reduce serum TG, TC, LDL and VLDL but no significant effect on HDL [38].…”