Antihyperlipidaemic Efficacy of Trachyspermum ammi in Albino Rabbits

Abstract

The objective of the present study was to investigate the antihyperlipidaemic efficacy of Trachyspermum ammi (L) Sprague, seed (Ajowan) powder in albino rabbits. Hyperlipidaemia was induced with butter ad libitum and oral intubation of cholesterol 400 mg/kg body weight. Simvastatin, (Tablet survive ® ) was used as a synthetic cholesterol lowering drug. The results suggest that 2 g/kg T. ammi seed powder produced hypolipidaemic activity, rendering 49%, 53%, 71% and 63% reduction in total lipids, triglycerides, total cholesterol and LDL-cholesterol, respectively. However, at this dosage level 62% increase in the value of HDL-cholesterol was induced by T. ammi seed powder. Nonetheless, 0.5 g/kg and 1 g/kg T. ammi seed powder did not show antihyperlipidaemic activity.T. ammi seed powder at the rate of 2 g/kg and simvastatin (0.6 mg/kg body weight) were equally effective in treating hyperlipidaemia in albino rabbits. Moreover, this dosage level also significantly reduced the cholesterol content of liver tissue. It can be anticipated that the lipid lowering mechanism may involve enhanced removal or catabolism of lipoproteins, inhibition of HMG COA reductase, and/or inhibition of lysosomal lipid hydrolytic enzymes secreted by the liver.

Selected haematological and biochemical indicators in different breeds of rabbits

“…Values of glucose were not significantly different in rabbit breeds, average glucose values were similar to the results reported by Kaneko et al (1997). Cholesterol content in the examined rabbit breeds corresponded with the range in growing rabbits presented by Burnett et al (2006) and Javed et al (2009). However, Kaneko et al (1997) and Flecknell (2000) indicated the physiological range 0.14-1.86 and 0.1-2.0 mmol·l -1 , respectively.…”

“…In CW, cholesterol did not vary from the MB and values obtained in other breeds. Values of TAG in our study were lower than in most references such as Rupić et al (1999), Corino et al (2002) and Javed et al (2009). In our study, significant differences in TAG concentration were found with the highest values in CW and the lowest in MW.…”

Potential role of medicinal plants for anti-atherosclerosis activity

“…The study was done on Albino rats by giving the powder form of this plant. Results have shown the significant reduction in the cholesterol level, lipid deposition and atherosclerosis by hindering the effects of HMG-CoA reductase in rat (Javed et al, 2009). …”

Effect of Green Tea Leaves (Camellia Sinensis) and Carom Seeds (Trachyspermum Ammi) Extracts on Male Mice Exposed to Diazinon.

“…The main ingredient, i.e. isothymol and other active ingredients of crude extract of carum seeds have shown to possess antiaggregatory effects [48], anthelmintic [49], antihyperlipidemic [50], anti-filarial [51], insecticidal [52], kidney stone inhibitory [53], molluscicidal [20], mosquito repellent [54], and nematicidal activities [49].…”