Antihyperlipidemic Effect of Flavonoids from Prunus davidiana

Choi, Jae Sue; Yokozawa, Takako; Oura, Hikokíchi

doi:10.1021/np50073a022

Cited by 99 publications

(68 citation statements)

References 15 publications

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“…Moreover, apo-B-containing lipoprotein fractions are thought to be responsible for cholesterol deposition in atherosclerotic plaques (Choi 1991). Further, HDL alters the balance of non-esterified cholesterol between plasma and cell by increasing its utilization in the lecithin cholesterol acyl tranferase (LCAT) system to form cholesterol ester, which moves rapidly into the cell (Katzung 2001).…”

Section: Resultsmentioning

confidence: 99%

Antihyperlipidaemic Efficacy of Trachyspermum ammi in Albino Rabbits

Javed¹,

Khan²,

Muhammad³

et al. 2009

Acta Vet. Brno

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The objective of the present study was to investigate the antihyperlipidaemic efficacy of Trachyspermum ammi (L) Sprague, seed (Ajowan) powder in albino rabbits. Hyperlipidaemia was induced with butter ad libitum and oral intubation of cholesterol 400 mg/kg body weight. Simvastatin, (Tablet survive ® ) was used as a synthetic cholesterol lowering drug. The results suggest that 2 g/kg T. ammi seed powder produced hypolipidaemic activity, rendering 49%, 53%, 71% and 63% reduction in total lipids, triglycerides, total cholesterol and LDL-cholesterol, respectively. However, at this dosage level 62% increase in the value of HDL-cholesterol was induced by T. ammi seed powder. Nonetheless, 0.5 g/kg and 1 g/kg T. ammi seed powder did not show antihyperlipidaemic activity.T. ammi seed powder at the rate of 2 g/kg and simvastatin (0.6 mg/kg body weight) were equally effective in treating hyperlipidaemia in albino rabbits. Moreover, this dosage level also significantly reduced the cholesterol content of liver tissue. It can be anticipated that the lipid lowering mechanism may involve enhanced removal or catabolism of lipoproteins, inhibition of HMG COA reductase, and/or inhibition of lysosomal lipid hydrolytic enzymes secreted by the liver.

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Section: Resultsmentioning

confidence: 99%

Antihyperlipidaemic Efficacy of Trachyspermum ammi in Albino Rabbits

Javed¹,

Khan²,

Muhammad³

et al. 2009

Acta Vet. Brno

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“…The concentration of LDL-cholesterol (LDL-C) and the antherogenic index (A.I.) were calculated by the following equations according to the methods of Kim et al 21) and Choi et al 22) A.I.ϭ(TCϪHDL-C)/HDL-C Statistics All results are presented as meanϮS.E.M. The data were evaluated by one-way ANOVA using the SPSS program, and the differences between the means were assessed using Duncan's test.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats

Kim

Jeong

Jung

et al. 2008

Biological & Pharmaceutical Bulletin

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In this study, we investigated the hypolipidemic effects of Sophora flavescens in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. The MeOH extract and 4 fractions of S. flavescens were administered at doses of 250 and 100 mg/kg body weight, respectively, once a day for 3 d to the poloxamer 407-induced hyperlipidemic rats. Serum lipid levels such as total cholesterol (TC), triglycerides (TG), and low-density lipoprotein-cholesterol (LDL-C) were markedly elevated in the poloxamer 407-induced hyperlipidemic control rats, while lipid levels were significantly decreased in the rats administered the MeOH extract or 4 fractions of S. flavescens. In addition, serum high-density lipoprotein-cholesterol (HDL-C) was reduced in the poloxamer 407-induced hyperlipidemic control rats. However, oral administration of both the MeOH extract and 4 fractions significantly increased HDL-C levels. Of the tested fractions, the EtOAc fraction showed the strongest lipid-lowering effect, as well as a high antiatherogenic potential with atherogenic index (A.I.) values of less than 1.92. We also investigated the hypolipidemic effects of the main compounds of the EtOAc fraction, kurarinol and kuraridinol, using the hyperlipidemic and hypercholesterolemic animal models. Here, elevated TC, TG, and LDL-C levels in the poloxamer 407-induced hyperlipidemic and cholesterol-fed rats were significantly reduced after oral administration of the compounds, and HDL-C levels had a significant increase. Furthermore, A.I. values were lowered by administering kurarinol and kuraridinol. In particular, kuraridinol exhibited stronger protective activities against hyperlipidemia than kurarinol. These results suggest that S. flavescens and its constituents may be effective cholesterol-lowering agents and useful for preventing hypercholesterolemic atherosclerosis.

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“…While the majority of research has focused on the antioxidant roles of flavonoids, a number of reports have suggested that these compounds may also influence atherogenesis through an effect on lipid and lipoprotein metabolism (4,8,10,14,15,51,88,94,96). Investigation of naturally occurring compounds as regulators of triglyceride and cholesterol metabolism has particular therapeutic importance, as evidenced by the discovery of the first HMG-CoA reductase inhibitors derived from fungal fermentation products, which are now widely used for the treatment of hyperlipidemia.…”

Section: Lipid and Lipoprotein Metabolismmentioning

confidence: 99%

“…Naringin is present in grapefruit juice at concentrations of up to 800 mg/L (81) and occurs as a mixture of chiral isomers that vary markedly in proportion depending on the maturity of the fruit and the method of purification. Naringin and other naringenin glycosides can be found in a variety of other sources including propolis (73) and Prunus davidiana (14). Monotes engleri contains a prenylated form of naringenin (6-(1,1-dimethylallyl)naringenin) (86).…”

Section: Introductionmentioning

confidence: 99%