Antihyperlipidemic Compounds from the Fruit of Piper longum L.

Abstract

A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.

Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

“…The water and ethanolic extracts of saffron s flower had anti-nociceptive and anti-inflammatory activities by writhing test, xylene induced ear edema in mice and formalin induced edema in the rat paw. Those works support its traditional use as an anti-edematogenic remedy 17,27 .…”

Enhanced solubility of piperine using hydrophilic carrier-based potent solid dispersion systems

“…[32][33][34] Nevertheless, the application of piperine as potential drug is limited due to the poor solubility in aqueous medium which would lead to the complication of poor bioavailability. Thus current challenges in pharmaceutical industries are to develop advanced formulation strategies to enhance the rate of water solubility of active pharmaceutical ingredients (APIs) and to develop potential drug delivery systems and biomaterials.…”

New amide alkaloids from Piper longum fruits

“…Uses include expectorant, curing dyspepsia, sleep problems, asthma, nausea, diarrhea, lumbarleg pain and arthralgia. 1 The plant mainly contains amide alkaloids which have been used with anti-hepatitis B virus (anti-HBV), 2,3 apoptotic, 4 leishmanicidal, 5 cytotoxic, 6 mosquito larvicidal, 7,8 phytotoxic, 9 anti-inflammatory, 10 antihyperlipidemic, 11,12 cell adhesion inhibitory, 13 antiplatelet, 11,14 acylCoA: cholesterol acyltransferase (ACAT) inhibitory, 15 antifungal 16 and coronary vasorelaxant activities. 17 In addition to amide alkaloids, phytochemicals present also include prenylated phenolic compounds 18 and aromatic esters 19 are found in the plant.…”