Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Zhang, Yuanbin; Wang, Xinfang; Ma, Ling; Dong, Lin; Zhang, Xinhui; Chen, Jing; Fu, Xueyan

doi:10.5650/jos.ess14061

Cited by 19 publications

(11 citation statements)

References 44 publications

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“…Moreover, the use of CO (in NEG1) instead of oleic acid (in NEG2) significantly increases the anesthetic activity. Moreover, the significant local anesthetic activity demonstrated by NEG1 in rats compared with these results could be justified on the basis of the established analgesic activity of CO [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

et al. 2021

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Oral health is a key contributor to a person’s overall health and well-being. Oral microbiota can pose a serious threat to oral health. Thus, the present study aimed to develop a cinnamon oil (CO)-loaded nanoemulsion gel (NEG1) to enhance the solubilization of oil within the oral cavity, which will enhance its antibacterial, antifungal, and analgesic actions against oral microbiota. For this purpose, the CO-loaded nanoemulsion (CO-NE) was optimized using I-optimal response surface design. A mixture of Pluracare L44 and PlurolOleique CC 497 was used as the surfactant and Capryol was used as the co-surfactant. The optimized CO-NE had a globule size of 92 ± 3 nm, stability index of 95% ± 2%, and a zone of inhibition of 23 ± 1.5 mm. This optimized CO-NE formulation was converted into NEG1 using 2.5% hydroxypropyl cellulose as the gelling agent. The rheological characterizations revealed that the NEG1 formulation exhibited pseudoplastic behavior. The in vitro release of eugenol (the marker molecule for CO) from NEG1 showed an enhanced release compared with that of pure CO. The ex vivo mucosal permeation was found to be highest for NEG1 compared to the aqueous dispersion of CO-NE and pure cinnamon oil. The latency reaction time during the hot-plate test in rats was highest (45 min) for the NEG1 sample at all-time points compared with those of the other tested formulations. The results showed that the CO-NEG formulation could be beneficial in enhancing the actions of CO against oral microbiota, as well as relieving pain and improving overall oral health.

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Section: Resultsmentioning

confidence: 99%

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

et al. 2021

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“…In this sense, the high temperatures employed for steam distillation can lead to the conversion of terpenes or thermolabile phenolics to less active molecules, reducing the quality of the final extract. Moreover, solvent extraction can contaminate the essential oils [45].…”

Section: Green Extraction Techniques For Obtaining Antiviral and Anti-inflammatory Compoundsmentioning

confidence: 99%

“…In-vitro and/or in-vivo activity of tested extracts has been attributed to structures like guaiol, pinocamphone, caryophyllene oxide, spathulenol, isoborneol, curdione, vellaral, procurcumadiol, germacrone, curcuminoids, β-selinene, aromadendrene, β-elemene, or cis-piperitol, among others. GC-MS methods are also the traditional choice for the profiling analysis of these terpenoids [38,45,[50][51][52][53][54][55][56], as well as for fatty acids (e.g, palmitic, oleic, linoleic, linolenic, EPA and mead acids) [29] [57], that contribute to the anti-inflammatory composition of essential oils and other natural extracts obtained by SFE. GC-FID is a low-cost analytical alternative, which has been reported for the analysis of anti-inflammatory fatty acids, sterols and terpenes in SFE extracts [58,59].…”

Section: Phytochemical Profiling Of Natural Antiviral and Anti-inflammatory Compoundsmentioning

confidence: 99%

Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources

Poletto

Álvarez-Rivera

Torres

et al. 2020

TrAC Trends in Analytical Chemistry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Zhang et al [24] tested the effect of the aroma oils of white pepper (Piper nigrum L. (Piperaceae)), long pepper (Piper longum L.), cinnamon (Cinnamomum cassia Presl. (Lauraceae)), saffron (Crocus sativus L. (Iridaceae)) and myrrh (Commiphora myrrha Engl.…”

Section: Animal Studiesmentioning

confidence: 99%

“…The following major constituents have been analysed by GC/MS: β-selinene, aromadendrene, β-elemene, cis piperitol, cis-βguaiene, 3-heptadecene, δ-cadinene, and β-cadinene. The authors deduced that the aroma oil recipe used in their study may be helpful in stroke treatment [24]. The sesquiterpene β-elemene, for example, is able to pass through the blood-brain barrier and may help to resist inflammation caused by stroke [25].…”

Section: Animal Studiesmentioning

confidence: 99%

Essential Oils and Compounds against Pains in Animal Studies

Schabauer

Steflitsch

Buchbauer

2017

Natural Product Communications

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The positive impact of essential oils and compounds has been known for a long time. Essential oils are multicomponent mixtures and obtained by steam distillation of leaves or flowers or simply by pressing orange peels for example. Due to the broad-spectrum activity, essential oils can be used for a variety of disorders like sleeping problems, colds or gastrointestinal complaints. The focus of this paper is the use of essential oils against pain in animal studies. The broad use of analgesics like NSAIDs against headaches or menstrual cramps for example, is often associated with unpleasant side effects. Essential oils may help to reduce the analgesic doses.

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Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Cited by 19 publications

References 44 publications

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota

Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources

Essential Oils and Compounds against Pains in Animal Studies

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