Antihyperlipidemic and hepatoprotective properties of selenium modified polysaccharide from Lachnum sp.

Surhio, Maheen Mahwish; Wang, Yufen; Xu, Ping; Shah, Faisal; Li, Jinglei; Ye, Ming

doi:10.1016/j.ijbiomac.2017.01.148

Cited by 55 publications

(21 citation statements)

References 44 publications

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“…It is reported that high-fat diet as a major contributing factor in the excessive energy intake would lead to the accumulation of fat throughout many tissues, especially in liver [1]. When high-fat diet is consumed for a certain period, lipid and cholesterol are produced and stored faster in the liver cells, which cause lipid and fat metabolism disorder, as a consequence, the fatty liver of fatty degeneration or steatosis occur [1]. We therefore analyzed the effects of PEP on the development of fatty liver in this study, which was strong associated with hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

“…Acontrol − Asample Acontrol × 100. (1) where Acontrol is the absorbance of the blank control reaction (containing all reagents except the sample) and Asample is the absorbance in the pesence of the sample.…”

Section: Dpph Radical Scavening Activity (%) =mentioning

confidence: 99%

“…Hyperlipidemia is one of the major endocrine diseases and has been incriminated as a contributory factor of atherosclerosis [1]. Epidemiological studies have demonstrated strong causal relations between lipid parameters level and hyperlipidemia [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…The excess intake of cholesterol-rich or high-fat diet will lead to metabolic dysfunctions of lipid, resulting in hyperlipidemia. Elevated levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and atherosclerosis index (AI) coupled with reduced serum high-density lipoprotein cholesterol (HDL-C) level are considered to be major risk factors for the development of many lipid-related diseases such as atherosclerosis or cardiovascular disease [1]. Furthermore, high levels of dietary fat could increase oxidative stress and decrease antioxidant enzyme activities.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Jiang

Lin

et al. 2020

Marine Drugs

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The aims of this study were to investigate the antioxidant, hypolipidemic and hepatic protective effects of Phascolosoma esculenta polysaccharides (PEP). PEP was prepared from Phascolosoma esculenta by enzyme hydrolysis and its characterization was analyzed. The antioxidant activities of PEP were evaluated by the assays of scavenging 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radicals and chelating ferrous ion in vitro. It showed that PEP could scavenge radicals effectively and had favorable antioxidant activities. In the meantime, the hypolipidemic effect of PEP was investigated in vivo by using mice model fed with high-fat diet with or without PEP treatment. Compared with the hyperlipidemic mice without treatment, the serum levels of total cholesterol (TC) (30.1–35.7%, p < 0.01), triglyceride (TG) (24.5–50.8%, p < 0.01 or p < 0.05), low-density lipoprotein cholesterol (LDL-C) (49.6–56.8%, p < 0.01) and liver levels of TC (21.0–28.4%, p < 0.01), TG (23.8–37.0%, p < 0.01) decreased significantly, whereas serum high-density lipoprotein cholesterol (HDL-C) (47.7–59.9%, p < 0.01 or p < 0.05) increased significantly after treatment with different dosage of PEP (0.2, 0.4 and 0.8 g per kg body weight, respectively). In addition, superoxide dismutase (SOD) (10.2–22.2% and 18.8–26.9%, p < 0.05), glutathione peroxidase (GSH-Px) (11.9–15.4% and 26.6–30.4%, p < 0.05) activities in serum and liver enhanced markedly while aspartate aminotransferase (AST) (18.7–29.6% and 42.4–58.0%, p < 0.05), alanine transaminase (ALT) (42.7–46.0% and 31.2–42.2%, p < 0.05) activities, as well as the levels of malondialdehyde (MDA) (15.9–24.4% and 15.0–16.8%, p < 0.01 or p < 0.05) in serum and liver reduced markedly. Moreover, the histopathological observation of livers indicated that PEP could attenuate liver cell injury. The animal experimental results demonstrated that PEP exerted hypolipidemic and hepatoprotective roles in hyperlipidemic mice. In summary, our results above suggest that PEP might be a potential natural antioxidant and utilized as a therapeutic candidate for hyperlipidemia.

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Section: Discussionmentioning

confidence: 99%

Section: Dpph Radical Scavening Activity (%) =mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Jiang

Lin

et al. 2020

Marine Drugs

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“…The current work showed that both APS and EAPS alleviate the ethanol-induced hepatocellular injuries. As for indicators on monitoring the lipid metabolism, the excess LDL-C in the blood can be easily oxidized, producing foam cells and blood/hepatic patches, while the HDL-C can eliminate surrounding tissue free cholesterol the liver, discharging from the body by bile acids and excretion, hence, elevated LDL-C levels and reduced HDL-C levels are also major factors in aggravating the liver diseases 42 . Therefore, it is essential to improve the lipid metabolism in the prevention and treatment of ALD.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects of Auricularia cornea var. Li. polysaccharides against the alcoholic liver diseases through different metabolic pathways

Wang¹,

Lan

Zhu

et al. 2018

Sci Rep

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The present work was designed to evaluate the antioxidation and hepatoprotective effects of Auricularia cornea var. Li. polysaccharides (APS) and enzymatic-extractable APS (EAPS) on the acute alcohol-induced alcoholic liver diseases (ALD). The in vitro antioxidant activities demonstrated that both APS and EAPS had strong reducing power and potential effects on scavenging reactive oxygen species. The in vivo mice experiments showed that the pretreatment with APS or EAPS showed potential hepatoprotective effects on the ALD possibly by increasing the antioxidant activities, reducing the lipid peroxidation, improving the alcohol metabolism, inhibiting the expression levels of inflammatory mediators and preventing the alcohol-induced histopathological alterations. In addition, the fourier-transform infrared (FT-IR), 1H and 13C nuclear magnetic resonance spectroscopy (NMR) and gas chromatography (GC) had been analyzed to obtained the primarily characteristics. The results indicated that abundant xylose and glucose contents probably had potential effects on possessing the bioactivities. The findings suggested that the A. cornea var. Li. might be considered as promising natural resource on exploring clinical drugs for the prevention and treatment with ALD and its complications.

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Selenoprotein‐Regulated Hydrogel for Ultrasound‐Controlled Microenvironment Remodeling to Promote Bone Defect Repair

Xu,

You,

Zheng

et al. 2024

Adv Funct Materials

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Abnormal levels of reactive oxygen species (ROS) and the hypoxic microenvironment within bone defects are important factors that impede bone repair processes. Herein, an innovative ultrasound‐modulatable hydrogel platform with selenoprotein‐mediated antioxidant effects to promote bone injury repair is presented. This hydrogel platform encapsulates oxygen‐enriched selene‐incorporated thin‐shell silicon within methacrylate gelatin (O2‐PSSG). The resultant construct orchestrates the modulation of the bone‐defect microenvironment, thereby expediting the course of bone regeneration. Ultrasound (US) is used to regulate the pore size of the hydrogel to release selenium‐containing nanoparticles and promote the in situ synthesis of efficient intracellular selenoproteins and hydrogen peroxide consumption. As expected, O2‐PSSG rapidly releases selenocystine ([Sec]2) under US control to scavenge reactive oxygen species and maintain the homeostasis of bone marrow mesenchymal stem cells (BMSCs). Over time, the action of the system by selenoprotein increases the activation of Wnt/β‐catenin pathways and promotes the differentiation of BMSCs. Consequently, O2‐PSSG potentiates the antioxidant proficiency of BMSCs both in vitro and in vivo, alleviates hypoxic environments, promotes osteogenic differentiation, and expedites cranial bone repair in rat models. In summary, this study suggests that the designed and constructed US‐responsive antioxidant hydrogel is a promising prospective strategy for addressing bone defects and fostering bone regeneration.

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Antihyperlipidemic and hepatoprotective properties of selenium modified polysaccharide from Lachnum sp.

Cited by 55 publications

References 44 publications

Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Antioxidant, Hypolipidemic and Hepatic Protective Activities of Polysaccharides from Phascolosoma esculenta

Hepatoprotective effects of Auricularia cornea var. Li. polysaccharides against the alcoholic liver diseases through different metabolic pathways

Selenoprotein‐Regulated Hydrogel for Ultrasound‐Controlled Microenvironment Remodeling to Promote Bone Defect Repair

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