Hepatoprotective effects of Auricularia cornea var. Li. polysaccharides against the alcoholic liver diseases through different metabolic pathways

Abstract

The present work was designed to evaluate the antioxidation and hepatoprotective effects of Auricularia cornea var. Li. polysaccharides (APS) and enzymatic-extractable APS (EAPS) on the acute alcohol-induced alcoholic liver diseases (ALD). The in vitro antioxidant activities demonstrated that both APS and EAPS had strong reducing power and potential effects on scavenging reactive oxygen species. The in vivo mice experiments showed that the pretreatment with APS or EAPS showed potential hepatoprotective effects on the ALD possibly by increasing the antioxidant activities, reducing the lipid peroxidation, improving the alcohol metabolism, inhibiting the expression levels of inflammatory mediators and preventing the alcohol-induced histopathological alterations. In addition, the fourier-transform infrared (FT-IR), 1H and 13C nuclear magnetic resonance spectroscopy (NMR) and gas chromatography (GC) had been analyzed to obtained the primarily characteristics. The results indicated that abundant xylose and glucose contents probably had potential effects on possessing the bioactivities. The findings suggested that the A. cornea var. Li. might be considered as promising natural resource on exploring clinical drugs for the prevention and treatment with ALD and its complications.

Dendrobium officinale Flower Extraction Mitigates Alcohol‐Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti‐Inflammatory

“…Alcohol metabolism produces many reactive oxygen radicals, and oxidative stress is an essential mechanism of alcoholic liver injury [ 33 – 35 ]. In the pathogenesis of alcohol-induced liver injury, oxidative stress plays a crucial role [ 36 ].…”

Hepatoprotective Potential of Partially Hydrolyzed Guar Gum against Acute Alcohol-Induced Liver Injury in Vitro and Vivo

“…polysaccharides (APS) were reported to protect liver tissue against acute alcohol toxicity. Cellular architecture of acute alcohol intoxicated liver sections was recovered by APS with just mild steatosis and necrosis [31]. Administration of MP-1 alleviated liver damage due to attenuated alcohol-induced oxidative damage [30].…”

Effect of different drying temperatures on the rehydration of the fruiting bodies of Yu Muer (Auricularia cornea) and screening of browning inhibitors

“…It is rich in nutrients, including physiologically active substances such as polysaccharides, proteins, amino acids, di(2‐ethylhexyl) adipate, and myristicin aldehyde. Pharmacological tests have indicated that it possesses high anti‐inflammatory and anticancer activities, can effectively lower blood sugar, and has certain therapeutic effects on antidiabetic and alcoholic liver disease (Wang, Jiang, et al, 2019a; Wang, Li, et al, 2019b; Wang et al., 2018). The commercial production of Yu Muer has reached over 50 million bags thus far in multiple provinces in China, with the products being sold to South Korea and Japan.…”