Antihyperlipidemic activity of <i>Achyranthes aspera</i> Linn leaves on cholesterol induced hyperlipidemia in rats

C.N, Sarvesh.; Fernandes, J.; Janadri, Suresh; H.S, Yogesh; Swamy, Shivakumar

doi:10.5958/0974-360x.2017.00043.9

Cited by 12 publications

(5 citation statements)

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“…Administration of extracts of A. aspera significantly reduces lipid peroxidation towards the normal value [108]. Oral administration of ethanolic and aqueous extract of powdered leaves significantly lowers the serum cholesterol and serum triglyceride level in cholesterol-induced hyperlipidemic rats in a dose-dependent manner compared with standard Atorvastatin [109]. The mechanism behind the hypolipidemic activity of A. aspera is to lowering exogenous absorption of cholesterol and rapid excretion of bile acids by endogenous conversion of cholesterol.…”

Section: Hypolipidemic Activitymentioning

confidence: 99%

Phytochemical Profile and Pharmacological Aspects of Achyranthes aspera Linn- An Overview

Nargatti¹,

Patil²,

Wadkar³

2021

JPRI

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Background: Achyranthes asperaLinn, commonly known as Apamarga in Ayurveda (Prickly Chaff flower in English, Aghara in Hindi, Aghada in Marathi), is aannual, perennial herb that belong to Family Amaranthaceae and Genus Achyranthes consisting of several species which are popular as folk remedies. Certain ayurvedic and Unani practitioners use various parts of plant to treat various diseases.The present review aims to provide up-to-date information on different aspects of plant involving its botanical description, phytochemistry and bioactivities of different extractsto assess its therapeutic potential as a valuable source of natural compounds with beneficial effects on human health. Methodology: Systematic search of scientific databases like Google, Google scholar, PubMed, Web of Science, Science Direct, SciFinder, Springer link were used to find potentially significant scientific research and reports of Achyranthes asperaLinnusing combination of relevant keywords. Results: Achyranthes aspera Linn is a popular folk remedy in the traditional medicinal system in all tropical Asian and African countries. So far,58 important compounds have been isolated and identified from various parts of plant. These isolated constituents are mainly flavonoids, tannins, terpenoids, saponins, phytosterols; phenolic compounds etc which posseses activities like anti-inflammatory, antimicrobial, anti-oxidant, hypoglycemic, antihyperlipidemic, spermicidal and other various important medicinal properties. Conclusion: Even though this plant consists of a wide range of phytochemicals and evaluated forbiological activities using various in-vitro and in-vivo models but they are limited. More attention should be paid to identify mechanisms that underlie beneficial therapeutic potential.It is essential to conduct the next level of research, by extending pharmacological to design novel drugs.

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Section: Hypolipidemic Activitymentioning

confidence: 99%

Phytochemical Profile and Pharmacological Aspects of Achyranthes aspera Linn- An Overview

Nargatti¹,

Patil²,

Wadkar³

2021

JPRI

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“…It has shown potential in inducing resistance to the adverse effects of ozone hole [39,40]. Additionally, it has been shown to possess antifertility, antiobesity, and larvicidal ability [19,[41][42][43][44].…”

Section: Achyranthes Asperamentioning

confidence: 99%

Rapid treatment of greywater (household sewage) by terrestrial weed Achyranthes aspera in SHEFROL® reactors

Abbasi

Tauseef

2018

Env Prog and Sustain Energy

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In arguably the first‐ever study of its kind, a common terrestrial weed, Achyranthes aspera, has been used to treat greywater (domestic sewage) of wide‐ranging strength. The weed was used in the novel SHEFROL® (SHEet Flow ROot Level) bioreactor earlier developed by the authors, of which a patent claim has been registered. Without the use of soil or any other anchor, and at very brisk rate reflected in low hydraulic retention times of just 4–6 h, A. aspera was able to achieve substantial secondary treatment and significant primary and tertiary treatments of the greywater in a clean and inexpensive fashion. Biological and chemical oxygen demands were removed to the extents of about 81 and 84%, respectively, suspended solids to the extent of 96%, and nitrogen, phosphorous, and heavy metals, to the extent of 28–41%. © 2018 American Institute of Chemical Engineers Environ Prog, 38: 467–476, 2019

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“…Keywords: Diabetes mellitus, ciplukan herb, lipid profile, Sprague dawley, streptozotocin, lipopolysaccharide. Transfer trigliserida menuju hati akan lebih banyak menghasilkan HDL karena sisa-sisa protein dari pelepasan trigliserida akan meningkatkan terbentuknya HDL 10,11,12 .…”

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Pengaruh Pemberian Ekstrak Ciplukan (Physalis Angulata L.) Terhadap Profil Lipid Tikus Jantan Galur Sprague Dawley Diberi Suntikan Streptozotocin dan Lipopolisaccaride

Rafika

Sulistyowati

Setiyobroto

2022

jurnal. ilmiah. respati.

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Diabetes Melitus (DM) merupakan penyakit metabolik yang ditandai dengan hiperglikemia dan sering dijumpai dengan kelainan metabolisme lipid. Metabolisme lipid ditandai dengan peningkatan maupun penurunan fraksi lipid dalam plasma. Kelainan fraksi lipid yang utama adalah kenaikan kadar kolesterol total, kolesterol LDL, kadar Trigliserida serta penurunan kadar kolesterol HDL. Ada banyak tanaman herba di Indonesia yang bersifat antioksidan yang dapat menjadi obat antidiabetes. Herba ciplukan adalah salah satu tanaman obat di Indonesia yang telah terbukti secara empiris sebagai antidiabetes. Penelitian ini untuk mengetahui pengaruh pemberian ekstrak ciplukan (Physalis angulata L.) terhadap profil lipid tikus jantan galur Sprague dawley diberi suntikan streptozotocin dan lipopolysaccharide. Jenis penelitian adalah penelitian eksperimen murni (true experiments design) dengan rancangan penelitian Posttest Only Control Group Design. Subjek penelitian adalah 20 ekor tikus jantan Sprague dawley diberi suntikan streptozotocin dan lipopolysaccharide. Pemberian herba Ciplukan dengan berbagai variasi dosis (5, 10, 20 mg/kg BB) selama 21 hari. Pada hari ke-22 pengambilan sampel darah untuk pengujian kadar profil lipid. Data dianalisis dengan uji Anova dan Bonferroni. Hasil penelitian memeprlihatkan bahwa kadar profil lipid pada kelompok perlakuan lebih baik dari kontrol. Kadar trigliserida pada kelompok perlakuan lebih rendah dari kontrol. Kadar LDL pada kelompok perlakuan lebih rendah dari kelompok kontrol. Kadar HDL pada kelompok perlakuan lebih tinggi dari kontrol. Kadar kolesterol pada kelompok perlakuan lebih rendah dari kontrol. Ada pengaruh pemberian ekstrak Ciplukan terhadap profil lipid. Kata Kunci : Diabetes mellitus, herba ciplukan, profil lipid, Sprague dawley, streptozotocin, lipopolysaccharide.

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Antihyperlipidemic activity of Achyranthes aspera Linn leaves on cholesterol induced hyperlipidemia in rats

Cited by 12 publications

References 0 publications

Phytochemical Profile and Pharmacological Aspects of Achyranthes aspera Linn- An Overview

Phytochemical Profile and Pharmacological Aspects of Achyranthes aspera Linn- An Overview

Rapid treatment of greywater (household sewage) by terrestrial weed Achyranthes aspera in SHEFROL® reactors

Pengaruh Pemberian Ekstrak Ciplukan (Physalis Angulata L.) Terhadap Profil Lipid Tikus Jantan Galur Sprague Dawley Diberi Suntikan Streptozotocin dan Lipopolisaccaride

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