Antihyperglycemic, Vasodilator, and Diuretic Activities of Microencapsulated Bioactive Product from Moringa stenopetala Leaves Extract

Abstract

Moringa stenopetala has nutritional and medicinal values, which is widely used by the local communities. The study aimed to evaluate the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated bioactive product from M. stenopetala leaves extract. Microencapsulation of the extract was done by spray drying technique using maltodextrin and pectin as coating materials with the core: coating ratio of 1 : 6. Then, the antihyperglycemic, diuretic, and vasodilator activities were evaluated after the product was administered to experimental animals at different doses and compared with the control groups. There were no observed physical, behavioral, and physiological changes on the mice during the acute toxicity test. The results also indicated no toxicity signs and death occurrence in the experimental animals up to 5000 mg/kg administered dose. Therefore, microencapsulated M. stenopetala leaves extract does not produce adverse effects in experimental mice. The study also showed that the microencapsulated bioactive product exhibited significant antihyperglycemic, vasodilator, and diuretic activities as the doses increase. Therefore, the study showed that microencapsulated bioactive product has significant medicinal values. Further detailed studies are recommended on chronic toxicity tests and to understand the possible mechanism of actions on the antihyperglycemic, vasodilator, and diuretic activities of the microencapsulated product.

Medicinal Plant Extracts Evaluated In Vitro and In Vivo for Antidiabetic Activities in Ethiopia: Bases for Future Clinical Trials and Related Investigations

“…e extracts also decreased postprandial BGL (P < 0.001) at 750 mg/kg dose [67]. e maltodextrin (9%) and pectin (1%) of leaves extract of M. stenopetala had also shown significant (P < 0.05) decrease in BGL with dosedependent manner in the same model [84]. e antihyperglycemic activity of M. stenopetala was supported by leaves extraction and fractionation in alloxaninduced male diabetic mice.…”

“…The extracts also decreased postprandial BGL ( P < 0.001) at 750 mg/kg dose [ 67 ]. The maltodextrin (9%) and pectin (1%) of leaves extract of M. stenopetala had also shown significant ( P < 0.05) decrease in BGL with dose-dependent manner in the same model [ 84 ].…”

“…The results of the findings indicate that the extracts of M. stenopetala produced potential antihyperglycemic effects due to various descriptions. It produced regeneration/proliferation of the pancreatic β -cells possibly due to the prevention of free radical formation [ 67 , 84 ]. Antiglycation activities may be associated with the presence of a high amount of phytochemicals such as polyphenolic compounds in the plant materials.…”

A comparative evaluation of serum lipid profile and blood pressure measurements in adult hypertensive patients consuming Moringa stenopetala herbal tea and non-consuming groups as control, South East Ethiopia, 2021

“…The potential mechanisms of action for the blood pressure-lowering effect of Moringa stenopetala were not determined in this study but have been explored by others. In vitro and animal studies show that Moringa stenopetala is a vasodilator [41,42], an angiotensin-converting enzyme inhibitor [43], and a diuretic [41,44], which ultimately leads to reduced blood pressure.…”

Evaluation of Antioxidant, Antihyperglycemic, and Antihyperlipidemic Effects of the 80% Methanolic Extract of Datura stramonium Linn (Solanaceae) Leaves in Streptozotocin-Induced Diabetic Mice

“…Phytochemicals play a major role in antihyperglycemic, antihyperlipidemic, and antioxidant activities (21,22). Bioactive compounds are obtained from various medicinal plant sources, including avonoids, phenolic, alkaloids, terpenoids, saponins, tannins, glycosides, glycolipids, dietary bres, carotenoids, anthocyanins have been reported to have potent antidiabetic activity (23).…”