Antihyperglycemic Effects Of Separate And Composite Extract Of Root Of &lt;i&gt;Musa paradisiacal&lt;/i&gt; And Leaf Of &lt;i&gt;Coccinia indica&lt;/i&gt; In Streptozotocin-Induced Diabetic Male Albino Rat.

Mallick, Chhanda; Chatterjee, Kanu; GuhaBiswas, Mehuli; Ghosh, Debidas

doi:10.4314/ajtcam.v4i3.31230

Cited by 52 publications

(34 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hence, the need to reduce the risk of vascular complications by securing adequate glycemic, lipidemic, blood pressure and weight control [6]. Currently diabetes is controlled by diet, exercise, oral hypoglycemic agents and insulin therapy [7]. The high level of treatment failures, unpleasant side effects and enormous cost associated with diabetic therapy have generated an urgent need and desire for alternative treatments [8].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats

Emordi

Agbaje

Oreagba

et al. 2016

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundDiabetes mellitus is a metabolic disorder of multiple aetiology characterised by hyperglycemia resulting from defects in insulin secretion, insulin action or both. It is a global epidemic ravaging both developed and developing countries. The situation will worsen if nothing is done urgently. In fact, the need to identify natural products with antidiabetic potentials is of great importance as supported by several research efforts all over the world, in search of antidiabetic plant based products that are safe and efficacious. Available literatures show that several phytochemicals with antidiabetic properties have been identified in certain plants amongst which include Uvaria chamae. The potentials of Uvaria chamae as an antidiabetic and hypolipidemic drug-candidate are thus tested.MethodsDiabetes mellitus was experimentally induced after the rats were fasted overnight by administering intraperitoneally, 60 mg/kg streptozotocin. After 72 h, the rats with plasma glucose levels >200 mg/dl were classified as diabetic. A total of six groups containing five rats per group were used. One group of diabetic rats was untreated. Three diabetic groups, each were treated orally with 100, 250 and 400 mg/kg body weight of the extract. Another diabetic group was treated with insulin (0.5 IU/kg) subcutaneously. The control received 0.5 ml (2% solution) of acacia orally. The treatment was for 8 days. The effects of the extract on weight, plasma glucose and other biochemical parameters were evaluated using standard procedures.ResultsThe diabetic rats treated with the extract showed significant reductions (p < 0.05) in weight, plasma glucose levels, low density lipoprotein and cholesterol compared with the control. The 100, 250 and 400 mg/kg body weight of the extract showed maximum glucose reduction of 85.16, 81.50 and 86.02% respectively. Histologically the pancreas of the diabetic rats treated with the extract, showed clusters of variably sized regenerated islet of Langerhans within sheets of normal exocrine pancreas, while the pancreas of diabetic rats treated with insulin showed no islet of Langerhans.ConclusionThe study showed that Uvaria chamae caused weight loss and has good hypoglycemic and hypolipidemic activities that may reduce the risk of developing cardiovascular diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats

Emordi

Agbaje

Oreagba

et al. 2016

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…[4344] Treatment with ‘ Diashis ’ or ‘Glibenclamide’ in diabetic rats resulted in a significant recovery in hemoglobin and HbA 1c levels, which may be due to recovery in plasma glucose towards the control levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats

Bera¹,

De²,

Chatterjee³

et al. 2010

Int J Ayurveda Res

View full text Add to dashboard Cite

This study focuses on the effect of ‘Diashis’, a polyherbal formulation composed of eight medicinal plants for the management of streptozotocin (STZ)-induced diabetes in rats. As oxidative stress is one of the consequences of diabetes, the activities of hepatic antioxidant enzymes and metabolic enzymes were evaluated. Treatment with ‘Diashis’ in STZ-induced diabetic rats resulted in a significant (P < 0.01) recovery in the activities of hepatic hexokinase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase along with correction in the levels of fasting blood glucose, glycated hemoglobin, and liver and skeletal muscle glycogen. The oxidative stress status in the liver was corrected by ‘Diashis’ which was highlighted by the recovery in the activities of catalase, peroxidase, and glutathione-S-transferase along with the correction in the quantity of thiobarbituric acid-reactive substances and conjugated diene. ‘Diashis’ was not found to have any metabolic toxicity. The antidiabetic effects of ‘Diashis’ were compared with those of the antidiabetic drug, ‘Glibenclamide’.

show abstract

“…Roots of Musa paradisiaca are antihelmintic, flowers are astringent and fruits are mild laxative. It is also useful in celiac disease, constipation and peptic ulcer (Mallick et al, 2007). It has been found that bananas have curative properties both scientifically and traditionally.…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer potential of banana flower extract: An <i>in vitro</i> study

Nadumane

Timsina

2014

Bangladesh J Pharmacol

View full text Add to dashboard Cite

Banana (Musa paradisiaca) flower is rich in phytochemicals (vitamins, flavornoids, proteins) and has anti-oxidant properties. The anti-cancer activity of banana flower extract has been evaluated on the cervical cancer cell line HeLa. The anti-proliferative effects were evaluated by MTT assay. The extract was further purified by TLC and characterized by LC-MS method. The ethanol extract had significant cytotoxicity to HeLa cells with an IC50 of 20 µg/mL. By thin layer chromatography we could isolate three fractions out of which fraction 2 had exhibited maximum anti-proliferative effects with an IC50 value of <10 µg/mL. By LC-MS analysis, bioactive fraction was found to have an m/z value of 224.2 indicating it as a novel one. Article Info

show abstract

Antihyperglycemic Effects Of Separate And Composite Extract Of Root Of <i>Musa paradisiacal</i> And Leaf Of <i>Coccinia indica</i> In Streptozotocin-Induced Diabetic Male Albino Rat.

Cited by 52 publications

References 24 publications

Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats

Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats

Effect of Diashis, a polyherbal formulation, in streptozotocin-induced diabetic male albino rats

Anti-cancer potential of banana flower extract: An <i>in vitro</i> study

Contact Info

Product

Resources

About