Antihyperglycemic Effects of N-Containing Sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in Streptozotocin-Diabetic Mice

Nishimura, Hiroshi; Kimura, Ikuko; Chen, Fujun; Sugihara, Yoshiaki; Haruno, Motoko; Kato, Atsushi; Asano, Naoki

doi:10.1021/np970277l

Cited by 147 publications

(80 citation statements)

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“…It could effectively inhibit the postprandial hyperglycemia as a novel α-glucosidase activity inhibitor for diabetic therapy [8,11]. Decades ago, it had been found that 1-deoxynojirimycin (DNJ) was one of the alkaloids in mulberry strongly inhibiting α-glucosidase both in vitro and in vivo [44,45]. It was also reported that the hybrid of DNJ and polysaccharide from mulberry leaves may have antidiabetic activity by regulating the expression of the hepatic gluconeogenesis enzymes, glucokinase, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase [46].…”

Section: Discussionmentioning

confidence: 99%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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This experiment, based on the previous study on R. mori, introduces whole mulberry branch powder into the diet to treat diabetic mice. Mulberry branch bark powder (MBBP) was administered orally to streptozotocin (STZ)-induced type II diabetic (T2D) mice to investigate hypoglycemic effects. After a 4-week period of diet consumption containing 5%, 10% and 20% MBBP, the fasting blood glucose, body weight and the related western blotting were measured, pathologic and immunohistochemical were observed. The 20% MBBP group showed a significant reduction in hyperglycemia and hyperinsulinemia; fasting blood glucose and insulin decreased from 25.0 to 14.8 mmol/L and 26.5 to 16.0 mU/L, respectively. Pathologic and immunohistochemical observation showed that MBBP administration lead to the repair of pancreas cells and restoration of insulin secretion. Dietary MBBP was associated with the decrease in the contents of 3, 4-methylenedioxeamphetamine, 8-OHdG, aspartate aminotransferase, and alanine aminotransferase, and the increase in antioxidative ability and glucose tolerance. Western blotting (WB) analysis suggested that MBBP decreased the TNF-α levels, thus relieving inflammation and improving liver function. It also led to the downregulation of apoptosis factor expression. WB also confirmed that MBBP enhanced the gene expression of the key enzymes: insulin receptor, insulin receptor substrate, p-AKT, GSK3β, glycogen synthase, G6Pase and phosphoenolpyruvate carboxykinase, which are related to glucose metabolism in the liver, and increase the expression of the genes PDX-1, GLUT2, MafA, and glucokinase, related to insulin secretion. Thus, oral administration of MBBP regulated insulin secretion and effectively maintained normal levels of glucose metabolism in mice, which may be done by improving the antioxidant capacity and activating insulin signaling with T2D..

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Section: Discussionmentioning

confidence: 99%

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Yin

Liu

Zhang

2017

Food & Nutrition Research

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“…The extract derived from mulberry leaves potentiated the pilocarpine-induced salivary flow which was correlated with antihyperglycemic effects . Fagomine from mulberry leaves increased the plasma insulin level in STZ-diabetic mice, and this insulin release by fagomine might partly contribute to the antihyperglycemic action (Nojima et al, 1998;Taniguchi et al, 1998). The maximum reduction in blood glucose of leaf extract was ob-served among fruit, trunk bark and root bark (Hosseinzadeh & Sadeghi, 1999).…”

mentioning

confidence: 99%

.ALPHA.-Glucosidase Inhibitory Activity in Leaves of Some Mulberry Varieties

Yatsunami

Saito

Fukuda

et al. 2003

FSTR

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The seasonal and polyploidal changes of ␣-glucosidase (rat-intestinal) inhibitory activity in mulberry leaves were compared in 12 mulberry varieties. Enashi, Fusoumaru, No. 325 and Kenmochi which are classified as 3 major varieties in Japan were harvested in May or August as the field samples. Shimaguwa and the 3 different wild types such as Kuromiguwa, Nagamiguwa, Midoriguwa were harvested in May as the greenhouse samples. Some varieties harvested in the field or greenhouse indicated a difference in ␣-glucosidase. In the field Enashi was strong, while Kenmochi was rather weak. The seasonal changes of inhibition between May and August were differed among the varieties. The 3x variety in the field or greenhouse showed the strong inhibition within the same variety. Keywords: ␣-glucosidase, inhibitor, mulberry, Morus, polyploidy, variety Mulberry leaves (Morus alba L.) have been used as a traditional medicine with anti-inflammatory and anti-hyperglycemic action . The mulberry leaf component such as 1-deoxynojirimycin (DNJ;Yoshikuni, 1988;Asano et al., 1994), 2-arylbenzofuran derivatives (Basnet et al., 1993) and polyhydroxylated alkaloids (Asano et al., 2001) inhibit the activity of ␣-glucosidase of the small intestine, and also prevent sudden hydrolysis of disaccharides, absorption of glucose into the blood vessel, and resultant increase of blood glucose level. DNJ showed stronger inhibitory activity towards rat intestinal maltase and yeast ␣-glucosidase compared with DNJ-trehalamine-fused and -linked compounds (Shiozaki et al., 1998). The extract derived from mulberry leaves potentiated the pilocarpine-induced salivary flow which was correlated with antihyperglycemic effects . Fagomine from mulberry leaves increased the plasma insulin level in STZ-diabetic mice, and this insulin release by fagomine might partly contribute to the antihyperglycemic action (Nojima et al., 1998;Taniguchi et al., 1998). The maximum reduction in blood glucose of leaf extract was ob-served among fruit, trunk bark and root bark (Hosseinzadeh & Sadeghi, 1999).On the other hand, there are many reports concerning artificially polyploidy from the point of view of cytology (Seki & Oshigane, 1953, 1957, 1959Tojyo, 1954Tojyo, , 1963Tojyo, , 1966Das & Krishnaswami, 1964;Das et al., 1970) as mulberry breeding is extremely valuable for the sericulture. It is well accepted that major characteristics of 3, 4x polyploidy are indicated a large leaf, high saccharide content, high yield and high feed efficiency on silkworm among the different polyploidy. We observed that the changes of ␣-glucosidase inhibitory activity in leaves were occurred among mulberry polyploidy. Activity for lowering blood-glucose levels of autumn-rearing silkworm was higher than that of spring-rearing silkworm (Ryu et al., 1997). The changes in ␣-glucosidase inhibitory activity in leaves can be observed in some mulberry varieties, there is no reports concerning of seasonal or varietal changes on the ␣-glucosidase inhibition in leaves of any mulberry variety.In this study the ...

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“…Several animal studies have been conducted to date. Nojima and co-workers showed that administration of mulberry leaf extract restored impaired glucose metabolism and hyperglycemic conditions in streptozotocin-induced diabetic mice (Nojima et al, 1998;Kimura et al, 1995). At present, various mulberry food products, including teas, powders, and tablets, are commercially available in Japan and many other countries.…”

Section: Mulberrymentioning

confidence: 99%

Development of Mulberry Leaf Extract for Suppressing Postprandial Blood Glucose Elevation

Kimura¹

2011

Hypoglycemia - Causes and Occurrences

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Antihyperglycemic Effects of N-Containing Sugars from Xanthocercis zambesiaca, Morus bombycis, Aglaonema treubii, and Castanospermum australe in Streptozotocin-Diabetic Mice

Cited by 147 publications

References 14 publications

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice

.ALPHA.-Glucosidase Inhibitory Activity in Leaves of Some Mulberry Varieties

Development of Mulberry Leaf Extract for Suppressing Postprandial Blood Glucose Elevation

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