Antihyperglycemic Effects of Fruits of Privet (<i>Ligustrum obtusifolium</i>) in Streptozotocin-Induced Diabetic Rats Fed a High Fat Diet

S, Lee; Oh, Sangwon; Park, Kun-Young; Park, Bum-Ho; Kim, Jeong-Sook; Kim, Soon-Dong

doi:10.1089/jmf.2007.0000

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…Ligustrum ovalifolium L. is commonly called California privet or garden privet, is an ornamental semi-evergreen shrub original from East Asia, widely cultivated as ornamental plant. Ligustrum (privet) fruits are known to contain phenolic acids, flavonoids and triterpenoids, responsible for their antihyperglycemic, anticarcinogenic effect and immunomodulatory activity [ 3 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

et al. 2018

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The present study reports for the first time the efficacy of bioactive compounds from Ligustrum ovalifolium L. fruit extract as reducing and capping agents of silver nanoparticles (AgNPs), developing a green, zero energetic, cost effective and simple synthesis method of AgNPs. The obtained nanoparticles were characterized by UV-Vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier Transform Infrared spectroscopy (FTIR), confirming that nanoparticles were crystalline in nature, spherical in shape, with an average size of 7 nm. The FTIR spectroscopy analysis demonstrated that the AgNPs were capped and stabilized by bioactive molecules from the fruit extract. The cytotoxicity of the biosynthesized AgNPs was in vitro evaluated against ovarian carcinoma cells and there were found to be effective at low concentration levels.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

et al. 2018

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“…Herbal medicine plays vital role as hypolipidemic (Yadav et al, 2008), abortifacient and contraceptive (Yakubu et al, 2010), antihypertensive (Nworgu et al, 2008), effective for treating skin diseases (Ajibesin et al, 2008), wound healers, and hypoglycemic effects and antimicrobial activities (Lee et al, 2009). Herbal medicine has numerous advantages such as low-cost, affordability, availability, accessibility, acceptability, and low toxicity; however, there are various disadvantages of consuming herbal products which include inappropriate formulations, lack of adequate scientific proof of the plant, imprecise diagnosis dosage and unstandardized usage which can lead to serious health risk to the patients (Elujoba et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Toxicological assessment of the aqueous dried leaf extracts of Senna alata L. in wistar rats

Ugbogu¹,

Emmanuel²,

Elekwa³

et al. 2016

Afr. J. Pharm. Pharmacol.

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Senna alata is a medicinal plant that belongs to Leguminosae family. Different parts of the plant are used in folklore medicine for curing skin infections, abdominal pain, and gonorrhoea. Despite the use of S. alata in the treatment of various ailments, there is limited or no comprehensive scientific information on the toxicological evaluation of the dried leaf extract in the folklore medicine in Africa. This study therefore evaluated the extensive toxicological effects of the aqueous dried leaf extract of S. alata in wistar rats. In acute toxicity test, aqueous dried leaf extract of S. alata were administered orally up to 10 g/kg body weight to male wistar rats. In sub-acute study, the wistar rats were daily administered orally with aqueous dried leaf extract of S. alata at doses of 250, 500 and 1000 mg/kg for 14 days and haematological and biochemical parameters were determined and a histopathology of the liver and kidney were analysed. The results revealed that in acute toxicity study, no death was recorded within 24 h after oral administration. In the sub-acute study, the extract did not exhibit any significant difference (p > 0.05) on haemoglobin, red blood cells and mean corpuscular haemoglobin concentration in all the tested doses. Significant differences (p > 0.05) were observed on white blood cell, platelet, urea, aspartate aminotransferase, alkaline phosphatase, total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol. The histopathology of the liver and kidney did not reveal any pathological changes. Our findings revealed that aqueous dried leaf extract of S. alata is not toxic at the tested doses, indicating that it is safe for therapeutic uses at the tested doses.

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“…[1] Today, medicinal plants are increasingly being used in most parts of the world as hypolipidemic,[2] contraceptive, abortifacients, emmenagogues, or oxytocic, antihypertensive,[3] treatment for skin diseases, wound healers, antimicrobial, and hypoglycemic. [4] Ethnobotanical information indicates that more than 800 plants are used as traditional remedies for the treatment of diabetes. [5] Hence, a large number of medicinal plants are available, it is very important to do the scientific validation of the drug to know their side effects in treatment.…”

Section: Introductionmentioning

confidence: 99%

Effect of aqueous extract of Passiflora edulis on biochemical and hematological parameters of Wistar Albino rats

Devaki¹,

Beulah²,

Guenzet³

et al. 2012

Toxicol Int

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Passiflora edulis is traditionally used in folk lore medicine for the treatment of various ailments. To validate its use in traditional medicine, it is important to evaluate its toxicity in the animal system. Therefore, this study aimed to evaluate the toxicological effects of oral administration of aqueous leaf extract of P. edulis in Wistar albino rats. Acute toxicity tests were conducted by the oral administration of 200, 500, 1000 and 2000 mg/kg body weight of the animal. In subacute study, they were administered with various doses of aqueous extract of P. edulis (100, 200, 300, and 400 mg/kg body weight) to evaluate its toxicity for a period of 7 days. The effect of aqueous extract of P. edulis on organ weight, hematological, renal, and hepatic markers were analyzed. In acute toxicity study, no mortality was seen with in 24 h of the administration of P. edulis extract. No signs of neurological and behavioral changes were noticed with in 72 h. In the subacute study, the extract intake has not changed the hematological parameters such as RBC, WBC, and platelets and it was also found that the plasma level of amino transferases, ALP, urea, uric acid and, creatinine were also not altered by the administration of P. edulis extract throughout the study. The weight of organ was found to be unaltered in all the doses selected. The acute toxicity study reveals that the oral administration of the extract was found to be safe up to the dose level of 2000 mg/kg. The subacute study indicates that the extract is safe on the bone marrow function and it is neither hepatotoxic nor nephrotoxic. This supports the safety use of the aqueous extract of P. edulis in pharmacological studies.

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Antihyperglycemic Effects of Fruits of Privet (Ligustrum obtusifolium) in Streptozotocin-Induced Diabetic Rats Fed a High Fat Diet

Cited by 9 publications

References 39 publications

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

Biosynthesis of Silver Nanoparticles Using Ligustrum Ovalifolium Fruits and Their Cytotoxic Effects

Toxicological assessment of the aqueous dried leaf extracts of Senna alata L. in wistar rats

Effect of aqueous extract of Passiflora edulis on biochemical and hematological parameters of Wistar Albino rats

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