Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats

Harini, Ranganathan; Ezhumalai, Muthukrishnan; Pugalendi, Kodukkur Viswanathan

doi:10.1016/j.ejphar.2011.11.051

Cited by 86 publications

(45 citation statements)

References 20 publications

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“…BCA administration also controlled glucose metabolism by restoring activities of glucose 6-phosphatase and fructose 1,6-bisphosphatase to near normal. Although the activities of these enzymes increased significantly in the liver and kidney of diabetic rats (27) . The streptozocin-induced diabetic rats significantly lost weight compared to control rats (28) .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats

Sadri

Goodarzi

Saberi

et al. 2017

Braz. arch. biol. technol.

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Bioflavonoid-containing diets have been reported to be beneficial in diabetes. In the current study, the effect of Fasting blood glucose (FBG), Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and malondialdehyde (MDA) levels significantly increased and body weight, high density lipoprotein cholesterol (HDL-C), superoxide dismutase (SOD) and catalase (CAT) activity and total antioxidant status (TAS) significantly decreased in diabetic rats as compared to control rats. Oral administration of BCA in 10 and 15 mg/kg.bw, FBG, TG, TC,

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Section: Discussionmentioning

confidence: 99%

Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats

Sadri

Goodarzi

Saberi

et al. 2017

Braz. arch. biol. technol.

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“…18 Biochanin A that is isolated from soybean shows antihyperglicemic effect on STZ-diabetic rats. 19 Genestein, another soy isoflavone, has AGE inhibitor activity by capturing methyl glioksal that leads to the inhibition of the formation AGE. 20 Moreover, genestein regulates antioxidant genes expression involving estrogen receptors, ERK1/2 and NF B.…”

Section: Discussionmentioning

confidence: 99%

Expression of receptor advanced glycosilation end product (RAGE) and active caspase-3 of the streptozotocin-induced chronic diabetes mellitus Sprague Dawley rats’ sperm with soybean (Glycin max) powder suspension treatment

2013

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Diabetes mellitus (DM) affects all the process of spermatogenesis. Chronic hyperglycemia in DM increases the expression of receptor for advanced glycosilation end products (RAGE) that is responsible for the activation of signal production of reactive oxygen species (ROS) and caspase 3. Active caspase 3 plays an important role in cell apoptosis. Soybean (Glycin max) is reported to have antihyperglycemic and antiadvanced glycosilation end products (antiAGE) and antioxidants activities. The aim of this study was to evaluate the effect of soybean powder suspension on the expression of RAGE and active caspase 3 of diabetic rats' sperm. This was an experimental study with post test only control group design using 30 male Sprague Dawley rats, aged 11-12 weeks old and weighed 200-250g. The rats were divided into five groups with six rats in each group. Group 1 was non diabetic rats and Group 2 was diabetic rats that were given aquadest. Group 3-5 were diabetic rats that were given a soybean powder suspension at dose of 400; 800 and 1600 mg/kg body weight (BW)/day, respectively. Diabetic rats were made by induction of a single intraperitoneal injection of streptozotocin (STZ) at a dose of 60 mg/kg BW. Soybean powder suspension was ingested for four weeks after 14 days STZ induction. Blood glucose levels were monitored before and three days after STZ induction and four weeks after suspension ingestion. The expression of RAGE and active caspase-3 were analyzed using immunohistochemistry method four weeks after suspension ingestion. The results showed that soybean powder suspension ingestion significantly decreased blood glucose level of diabetic rats toward normality (p<0.05). However, the expression of RAGE and active caspase-3 in diabetic rats' sperm were not significantly lower than those after suspension ingestion. In conclusion, soybean powder suspension does not significantly affect the expression of RAGE and active caspase-3 in diabetic rats' sperm. ABSTRAKDiabetes melitus (DM) mempengaruhi semua proses spermatogenesis. Hiperglikemia kronis pada DM meningkatkan ekspresi receptor for advanced glycosilation end products (RAGE) yang bertanggung jawab terhadap aktivasi sinyal produksi reactive oxygen species (ROS) dan caspase-3. Caspase-3 aktif berperan penting pada apoptosis sel. Kedelai (Glycin max) dilaporkan memiliki aktivitas antihiperglikemia, antiadvanced glycosilation end products (antiAGE) dan antioksidan. Tujuan penelitian ini adalah mengevaluasi efek suspensi bubuk kedelai terhadap ekspresi RAGE 2 J Med Sci, Volume 45, No. 1, March 2013: 1-11 dan caspase-3 aktif pada sperma tikus diabetes. Penelitian ini merupakan penelitian eksperimental dengan rancangan post test only control group menggunakan 30 ekor tikus jantan Sprague Dawley, umur 11-12 minggu dan berat 200-250 g. Tikus dibagi menjadi lima kelompok dengan masing-masing kelompok 6 ekor. Kelompok 1, tikus tidak DM dan Kelompok 2, tikus DM yang diberi akuades. Kelompok 3-5, tikus diabetes yang diberi suspensi bubuk kedelai dengan dosis berturut-...

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“…Pharmacological studies have demonstrated that BCA possesses remarkable biological activities such as antioxidant, anti-inflammatory and antihyperglycemic effects (Kole et al, 2011;Yoon et al, 2011;Harini et al, 2012). In addition, BCA has been widely used as dietary supplement for treating premenstrual syndrome, lowering the cholesterol, improving urine production and preventing osteoporosis (Howes et al, 2000;Atkinson et al, 2004;Chedeaui et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Nanostructured lipid carriers as a delivery system of biochanin A

Wang¹,

Cheng²,

Zhou³

et al. 2013

Drug Delivery

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The aim of this study was to explore the nanostructured lipid carriers as a delivery system of biochanin A so as to supply a method to improve its bioavailability. Biochanin A-loaded nanostructured lipid carriers (BCA-NLCs) were prepared by the method of emulsionevaporation and low temperature solidification. Pharmacokinetics was carried out in rats upon oral administration at a dose of 10 mg/kg. BCA-NLC showed spherical formulation and had mean diameter174.68 AE 0.96 nm, zeta potential À20.9 AE 0.8 mv and entrapment efficiency 97.36 AE 0.14%. DSC and XRD studies indicated that BCA was not in crystal state in NLC. In in vitro release study, the BCA from BCA-NLC exhibited a biphasic release pattern with burst release initially and sustained release afterwards. BCA-NLC showed higher AUC value and circulated in blood for a longer time than BCA suspension. The studies demonstrated that NLC could be a potential delivery system for BCA to improve bioavailability.

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Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats

Cited by 86 publications

References 20 publications

Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats

Antioxidant Effects of Biochanin A in Streptozotocin Induced Diabetic Rats

Expression of receptor advanced glycosilation end product (RAGE) and active caspase-3 of the streptozotocin-induced chronic diabetes mellitus Sprague Dawley rats’ sperm with soybean (Glycin max) powder suspension treatment

Nanostructured lipid carriers as a delivery system of biochanin A

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