Antihyperglycemic effect of 18β-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats

Kalaiarasi, Panneerselvam; Pugalendi, Kodukkur Viswanathan

doi:10.1016/j.ejphar.2008.12.057

Cited by 76 publications

(45 citation statements)

References 28 publications

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“…[24] The streptozotocin induced diabetes is characterized by a severe loss in body weight. [25] The decrease in the body weight of diabetic rats in this study was due to the loss or degradation of structural proteins. Insulin plays an important role in the regulation of protein synthesis and proteolysis in skeletal muscle.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antidiabetic Effect of Citrullus Lanatus (Thunb) Seeds and Saraca Asoca (Roxb.) DE.WILD. Flowers in Streptozotocin-Induced Diabetic Rats

Shoba¹

2017

WJPPS

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Objective: To evaluate the in-vivo antidiabetic potential of the methanolic extracts of Citrullus lanatus seeds (CLS) and Saraca asoca flowers (SAF) in the streptozotocin (STZ) -induced rat model. Methods:Acute oral toxicity study was performed according to the OECD test guidelines and antidiabetic activity was carried out using STZ-induced diabetes in the male Sprague Dawley rats. The rats were treated with methanolic extracts of CLS and SAF at the dose of 100, 200 and 400 mg/kg of b.wt. administered orally for 28 days.Metformin was used as a standard drug at a dose of 100 mg/kg, b.wt.The antioxidant and histopathological studies were carried out using standard protocols. Results: The extracts did not show any sign of toxicity at a dose of 2000 mg/kg body weight. Oral administration of both the extracts at a dosage of 400 mg/kg body weight for 28 days resulted in a significant reduction in blood glucose, lipid profile (cholesterol, triglyceride), hepatic and renal markers (SGOT, SGPT, ALP, creatinine, urea and protein) when compared with the diabetic control. In in-vivo antioxidant enzymes study on both the extracts showed a significant (p<0.05) decrease in LPO level and increase in SOD and CAT levels as compared to the diabetic control.Histopathological studies of the liver, kidney and pancreas revealed normal histological pattern in the normal and treated groups. Conclusion: The experimental data revealed that both the extracts, CLS and SAF have significant antihyperglycemic and antioxidant activity in streptozotocin-induced rats compared to the standard drug.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antidiabetic Effect of Citrullus Lanatus (Thunb) Seeds and Saraca Asoca (Roxb.) DE.WILD. Flowers in Streptozotocin-Induced Diabetic Rats

Shoba¹

2017

WJPPS

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“…Various physical, biochemical and histomorphological parameters were evaluated to study the antihyperlipidemic effects [22]. In an independent study, oral dose of 100mg/kg of 18-β-glycirrhetic acid possess a suitable the anti-hyperglycemic effect in streptozotocin (40mg/ kg of body weight) induced diabetic rats that is comparable with glibenclamide [23].…”

Section: Therapeutic Potentials and Traditional Usesmentioning

confidence: 99%

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Thakur¹,

Raj²

2017

JAPLR

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The Glycyrrhiza genus contains more than 30 species and widely distributed all over the world [7]. Glycyrrhiza genus plants are wide spread in Mediterranean, Southern and Central Russia and Asia, being minor to Iran. Many species are now grown throughout Europe, Syria, Asia, UK, USA, Italy, France, Germany, AbstractGlycyrrhiza glabra Linn. (Family: Fabaceae) is a traditional medicinal plant used in various ancient medicine systems and documented across the globe for its ethanopharmacological value to cure varieties of ailments. Glycyrrhizin is the major active constituent obtained from liquorice roots, one of the most widely used in herbal preparations for the treatment and management of chronic diseases. The present mini-review is focused mainly on major secondary metabolites, ethnopharmacology and potential medicinal uses of Glycyrrhiza glabra. The sources for the literature search were PubMed, ScienceDirect, SciFinder and Google Scholar. Reported pharmacological activities, characterized secondary metabolites and traditional uses of Glycyrrhiza glabra warrants its potential therapeutic uses. However, further scientific validations along with evidencebased studies are still required in support to its traditional uses, to serve as "lead" for development of novel agents and a better drug candidate in future. Keywords:

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“…44 GL and GLA (2) were also reported as possessing a protective effect on acute cholestasis induced by α-naphtyl isocyanate in rats 45 and GLA was reported as an apoptosis inductor in human hepatoma, promyelotic leukemia and stomach cancer cells, 46 as an antihyperglycemic agent in rats with streptozocin-induced diabetes, 47 and as presenting antiviral activity against herpes simpex virus 1 (HSV-1). 48 Although several interesting biological activities are known for these two compounds, few molecular targets are described for them.…”

Section: New Pharmacological Activities Reported For Gl and Glamentioning

confidence: 99%

Glycyrrhizin and glycyrrhetic acid: scaffolds to promising new pharmacologically active compounds

Graebin¹,

Verli²,

Guimarães³

2010

J. Braz. Chem. Soc.

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O ácido glicirrizínico (GL), também conhecido como glicirrizina, é uma saponina triterpênica, um produto natural encontrado na raiz de Glycyrrhyza glabra L. ("licquorice" ou "alcaçuz"), utilizada mundialmente como edulcorante e também na medicina tradicional do Oriente. Este artigo de revisão enfoca os novos compostos sintetizados usando GL ou sua aglicona, o ácido glicirretínico (GLA), como materiais de partida e as atividades farmacológicas descritas para os mesmos e seus derivados.Glycyrrhizinic acid (GL), also known as glycyrrhizin, is a triterpene saponin, a natural product found on the root of Glycyrrhyza glabra L. ("licquorice"), used worldwide as sweetener and in the traditional eastern medicines. This review is focused on a series of new derivatives synthesized using GL and its aglycon, glycyrrhetinic acid (GLA), as starting materials, the pharmacological activities described for those compounds, as well as new activities reported for GL and GLA themselves.

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Antihyperglycemic effect of 18β-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats

Cited by 76 publications

References 28 publications

Evaluation of Antidiabetic Effect of Citrullus Lanatus (Thunb) Seeds and Saraca Asoca (Roxb.) DE.WILD. Flowers in Streptozotocin-Induced Diabetic Rats

Evaluation of Antidiabetic Effect of Citrullus Lanatus (Thunb) Seeds and Saraca Asoca (Roxb.) DE.WILD. Flowers in Streptozotocin-Induced Diabetic Rats

Pharmacological Perspective of Glycyrrhiza glabraLinn.: a Mini-Review

Glycyrrhizin and glycyrrhetic acid: scaffolds to promising new pharmacologically active compounds

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