Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes

Gupta, Shipra; Sharma, Suman; Bansal, Surendra K.; Prabhu, K. M.

doi:10.1016/j.jep.2009.02.019

Cited by 83 publications

(59 citation statements)

References 20 publications

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“…The antihyperglycemic effect shown by CLEt is consistent with our previous studies in experimentally induced diabetic rats and rabbits [15,37]. Other researchers have also shown blood glucose lowering effect of C. auriculata leaves in hydro-alcoholic and ethanolic extracts [14,38].…”

Section: Discussionsupporting

confidence: 90%

“…Previously, we have also demonstrated the antidiabetic effect of aqueous extract of C. auriculata leaves in experimental diabetes [15]. The present study demonstrates the antiatherosclerotic potential of C. auriculata aqueous leaf extract (CLEt) in streptozotocin (STZ) diabetic rat model.…”

Section: Introductionsupporting

confidence: 70%

“…Previously, we have shown 400 mg/kg body weight dose of CLEt as an effective dose in controlling hyperglycemia among the various doses tested i.e., 100, 200 and 400 mg/ kg body weight [15]. Therefore, 400 mg/kg body weight dose of CLEt was used for the treatment of the animals to study its effect on hyperglycemia-induced atherosclerotic environment.…”

Section: Experimental Designmentioning

confidence: 99%

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Salutary Effect of Cassia auriculata L. Leaves on Hyperglycemia-Induced Atherosclerotic Environment in Streptozotocin Rats

et al. 2011

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Diabetes mellitus is very often associated with dyslipidemia, increased oxidative stress and endothelial dysfunction that could develop atherosclerosis and consequently cardiovascular diseases. Medicinal plants with reputed traditional use to treat diabetes and cardiovascular diseases might provide valuable drugs. Therefore, the present study was designed to evaluate anti-atherosclerotic potential of aqueous extract of Cassia auriculata L. leaves in streptozotocin (STZ)-induced diabetic rats. The rats were rendered diabetic by STZ (45 mg/kg, ip). Diabetic rats were orally administered C. auriculata leaf extract at 400 mg/kg dose daily for 21 days. The supplementation of extract to the diabetic rats produced significant reduction in fasting blood glucose along with significant reversal in altered serum lipid profile and apolipoprotein B. Lipid peroxidation was found to be significantly suppressed in extract-fed diabetic rats. The significant reduction in serum levels of oxidized low-density lipoprotein, soluble vascular cell adhesion molecule and plasma fibrinogen with a concomitant elevation in serum nitric oxide was observed in diabetic rats following treatment with extract. Histopathological examination of heart myocardium of extract-treated diabetic rats revealed reversal of fatty change toward normal. These results suggest that C. auriculata aqueous leaf extract exhibits anti-atherosclerotic role in the diabetic state and it indicates toward the notion that extract may help to prevent the progression of cardiovascular diseases.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 70%

Section: Experimental Designmentioning

confidence: 99%

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Salutary Effect of Cassia auriculata L. Leaves on Hyperglycemia-Induced Atherosclerotic Environment in Streptozotocin Rats

et al. 2011

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“…The alloxan-induced diabetic rats showed a remarkable increase in the levels of lipid profiles such as TG, TC and lipoproteins including LDL-cholesterol, VLDL-cholesterol and marked the reduction in HDL-cholesterol [71]. In conditions of diabetes, a multifarious number of studies have demonstrated that there is an alteration of lipid profiles indicating a risk factor for CVD [72] [73].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i> Asparagus racemosus</i> Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

Mamun¹,

Hossain²,

Islam³

et al. 2017

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In recent years, the popularity of medicinal plants as a remedy has been increased manifold due to having minimal adverse effects. The current study aimed to compare the hypoglycemic, hypolipidemic and hepatoprotective effects of the ethanolic extract of Asparagus racemosus (EEAR) Linn. alone and combinedly with conventional antidiabetic agents (gliclazide and pioglitazone) in alloxan-induced diabetic rats. Diabetes was induced in male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w.). Effect of oral administration of two different doses of EEAR (200 and 400 mg/kg b.w.), gliclazide (10 mg/kg b.w.) and pioglitazone (10 mg/70kg/b.w.) alone for 2 weeks and a combination of EEAR (200 mg/kg b.w.) with either gliclazide (10 mg/kg b.w.) or pioglitazone (10 mg/70kg/b.w.) for 2 weeks were examined on hypoglycemic activity on 0 treatment as compared to that of disease control rats, gliclazide treated rats and pioglitazone treated rats. Proposed adjunct therapy also markedly (p < 0.001; p < 0.01, p < 0.001) improved serum TG, HDL and LDL level with insignificant change in VLDL and TC level while comparing with groups receiving gliclazide treated rats and pioglitazone treated rats. Administration of different doses of EEAR markedly (p < 0.05, p < 0.01, p < 0.001; p < 0.05, p < 0.01; p < 0.05) reduced the activity of TC, TG, LDL, VLDL and HDL cholesterol levels in a dose-dependent approach with respect to that of gliclazide treated rats and pioglitazone treated rats. The effect of combination therapy significantly (p < 0.001; p < 0.001; p < 0.01, p < 0.001) decreased the SGOT, SGPT and TP hepatic enzyme levels when compared to disease control rats, gliclazide treated rats and pioglitazone treated rats indicated improvement in liver dysfunctions. Administration of different doses of EEAR noticeably (p < 0.05, p < 0.01, p < 0.001; p < 0.05, p < 0.01; p < 0.05, p < 0.01) reduced the liver enzymes level including SGOT, SGPT and TP in a dose-dependent manner as compared to the disease control rats, gliclazide treated rats and pioglitazone treated rats. The maximum survival rate (100%) was observed in rats of combination treated rats. No significant changes in the body weight and organ weight to body weight ratio were observed except the groups that were given combined therapy showed improvement in the liver and pancreas weight. Our study suggests that the EEAR potentiates the activity of gliclazide and pioglitazone in controlling blood glucose levels, modifies the lipid profile and improves in liver dysfunction on alloxan-induced diabetic rats.

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“…The leaves are anthelmintic and good for ulcers, skin diseases and leprosy (Balakrishna et al, 2011). Previously reported activities of tarvada are antioxidant (Doshi et al, 2011), antidiabetic (Gupta et al, 2009), immunomodulatory (Chakraborthy, 2009), hepatoprotective (Dhanasekaran & Ganapathy, 2011), anthelmentic, antibacterial (Wadekar et al, 2011) and nephroprotective (Annie et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Jaydeokar

Bandawane

Bibave

et al. 2014

Pharmaceutical Biology

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Context: Tarvada [Cassia auriculata Linn. (Caesalpiniaceae)] is used against liver ailments in Indian folk medicine, but there is a lack of scientific evidence for this traditional claim. Objective: The present study investigated the protective effect of methanol extract of tarvada (MECA) roots on ethanol and antitubercular drug induced hepatotoxicity in rats. Materials and methods: In the therapeutic model, ethanol (40%, 4 g/kg b.w., p.o.) was administered to rats for 21 days and the intoxicated rats were treated with MECA (300 and 600 mg/kg, b.w.) and silymarin (100 mg/kg, b.w.) for next 7 days. In the prophylactic model, MECA and silymarin were administered simultaneously along with a combination of isoniazid (27 mg/kg, b.w.), rifampicin (54 mg/kg, b.w.) and pyrazinamide (135 mg/kg, b.w.) for 30 days. After the study duration, serum levels of AST, ALT, ALP, total bilirubin, total cholesterol, total protein, albumin were estimated along with hepatic catalase (CAT), reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA) and liver histopathology in each group. Results: Administration of tarvada root extract significantly (p50.01 and p50.05) lowered the elevated levels of serum AST, ALT, ALP, total bilirubin, total cholesterol, total protein and restored the abnormal levels of enzymatic antioxidants and MDA in liver due to toxicant administration in a dose-dependent manner. These results were confirmed by histopathological analysis. Discussion and conclusion: Results suggest that tarvada root extract possess potent hepatoprotective activity against ethanol and antitubercular drug-induced hepatotoxicity in rats, which could be due to an inhibition of hepatic metabolizing enzymes and antioxidant activity.

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Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes

Cited by 83 publications

References 20 publications

Salutary Effect of Cassia auriculata L. Leaves on Hyperglycemia-Induced Atherosclerotic Environment in Streptozotocin Rats

Salutary Effect of Cassia auriculata L. Leaves on Hyperglycemia-Induced Atherosclerotic Environment in Streptozotocin Rats

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i> Asparagus racemosus</i> Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

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Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes

Cited by 83 publications

References 20 publications

Salutary Effect of Cassia auriculata L. Leaves on Hyperglycemia-Induced Atherosclerotic Environment in Streptozotocin Rats

Salutary Effect of Cassia auriculata L. Leaves on Hyperglycemia-Induced Atherosclerotic Environment in Streptozotocin Rats

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of&lt;i&gt; Asparagus racemosus&lt;/i&gt; Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

Hepatoprotective potential ofCassia auriculataroots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

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Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i> Asparagus racemosus</i> Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats