Antihyperglycemic Activity of the Aqueous Stem Extract of<i>Coscinium fenestratum</i>. in Non–insulin Dependent Diabetic Rats

Shirwaikar, Annie; Rajendran, K.; Punitha, I.S.R.

doi:10.1080/13880200500387083

Cited by 16 publications

(8 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In case of TRG concentration, we found a tendency (P > 0.05) for lower TRG content with increasing bee pollen intake. Similar results were reported by Shirwaikar et al (2005). The TRG serum content in male rats is affected mainly by age (Lukačínová et al 2011b).…”

Section: Discussionsupporting

confidence: 79%

The effect of dietary bee pollen intake on growth performance and biochemical indicators of rats

et al. 2016

View full text Add to dashboard Cite

The aim of this study was to analyse the effects of different daily intakes of rapeseed bee pollen on the growth and biochemical blood serum indicators in male and female rats. A total of 40 clinically healthy male and female Wistar rats were randomly divided into four groups. In the control group (C) rats were fed a standard complete diet; in the experimental groups standard diets were supplemented with different doses of bee pollen. Treatment group T1 was given standard diet with the addition of bee pollen at a 0.3% concentration; in group T2 the addition was 0.5%; and in group T3 it was 0.75%. The experimental period lasted for 90 days. A significant effect (P < 0.05) of bee pollen on the body weight gain and feed conversion ratio of female rats was found. Significantly (P < 0.05) higher cholesterol concentration in blood serum of male rats was found in the groups with bee pollen addition (groups T2 and T3) compared to the control group. Lower triglyceride serum content in all female experimental groups (T1 and T3) was observed in comparison to the control. Higher serum cholesterol content in the experimental female rats was detected; significant differences were analysed in groups T1 and T3 compared to the control female group. Rapeseed bee pollen at concentrations of 0.5 and 0.75% positively affected the body weight gain of female rats, however, with higher feed consumption (P < 0.05). Rapeseed bee pollen reduced the triglycerides serum content in female rats and increased the cholesterol serum content in male and female rats (P < 0.05). Additives, efficiency, blood serum, model animals

show abstract

Section: Discussionsupporting

confidence: 79%

The effect of dietary bee pollen intake on growth performance and biochemical indicators of rats

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The increases in the serum triglycerides and total cholesterol in diabetic rats are in agreement with previous reports [36][37][38].…”

Section: Discussionsupporting

confidence: 93%

Hypoglycemic activity of constituents from Astianthus viminalis in normal and streptozotocin-induced diabetic mice

Gutierrez¹,

Solís

Baez³

et al. 2009

J Nat Med

View full text Add to dashboard Cite

Astianthus viminalis has been used as a medicinal plant for a long time owing to its many physiological actions such as anti-inflammatory and antidiabetic activities. A new tetracyclic triterpenoid 3beta,19alpha-dihydroxyurs-12,20(21)-diene-28-oic acid (1), known constituents oleanolic acid (2) and ursolic acid (3), and the coumarins 7,8-dimethoxycoumarin (4) and 7-methoxycoumarin (5) were isolated from the chloroform extract of the leaves of A. viminalis. The structure and relative configurations of 1 were determined by spectroscopic methods (1H- and 13C-NMR, IR, and MS) and 2D-NMR experiments. The hypoglycemic ingredients of A. viminalis were characterized as compounds 1-3. The hypoglycemic effect of the isolated natural product 1 was investigated in normoglycemic and streptozotocin (STZ)-induced diabetic mice. All effects were compared with those of tolbutamide. Triterpenoid 1 showed potent hypoglycemic and hypolipidemic effects in the STZ-induced diabetic mice. Continuous administration of 1 (30 mg/kg, orally) led to significant decrease in the level of glucose, triglycerides, total cholesterol, LDL, and VLDL in the diabetic mice, whereas the level of HDL did not alter significantly in any of the groups studied.

show abstract

“…Glycosylated haemoglobin was estimated by the method of Shirwaikar et al (2005) and serum magnesium levels by the method of Garfinkel (1988).…”

Section: Determination Of Glycosylated Haemoglobin and Serum Magnesiumentioning

confidence: 99%

“…Ancient Indian literature has prescribed various herbs in the treatment of diabetes mellitus. Many indigenous drugs have been used by the practitioners of the Ayurvedic system for the treatment of diabetes mellitus in India (Shirwaikar et al 2005).…”

mentioning

confidence: 99%

Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin-nicotinamide diabetic rats

Prabhu

Lobo

Shirwaikar

2008

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

We have investigated the possible antihyperglycaemic effects of Sphaeranthus indicus extract in rats rendered diabetic by nicotinamide (120 mgkg −1 i.p.) and streptozotocin (STZ) (60 mgkg −1 i.p). Fasting plasma glucose levels, serum insulin levels, serum lipid profiles, magnesium levels, glycosylated haemoglobin, changes in body weight and liver glycogen levels were evaluated in normal and diabetic rats. Oral administration of S. indicus for 15 days resulted in significant decrease in blood glucose levels and increases in hepatic glycogen and plasma insulin levels. Fasting normal rats treated with the alcoholic extract of S. indicus showed significant improvement in oral glucose tolerance test.Glibenclamide was used as a reference standard. The findings demonstrate that the alcoholic S. indicus extract may be useful in the treatment of diabetes.

show abstract

Antihyperglycemic Activity of the Aqueous Stem Extract ofCoscinium fenestratum. in Non–insulin Dependent Diabetic Rats

Cited by 16 publications

References 25 publications

The effect of dietary bee pollen intake on growth performance and biochemical indicators of rats

The effect of dietary bee pollen intake on growth performance and biochemical indicators of rats

Hypoglycemic activity of constituents from Astianthus viminalis in normal and streptozotocin-induced diabetic mice

Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin-nicotinamide diabetic rats

Contact Info

Product

Resources

About