Antihyperglycemic activity of Tectona grandis Linn. bark extract on alloxan induced diabetes in rats

Varma, Sushil Kumar; Jaybhaye, Deepali

doi:10.4103/0974-7788.72488

Cited by 12 publications

(5 citation statements)

References 11 publications

(15 reference statements)

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“…Previous phytochemical research reported that T. grandis was not only rich in flavonoids and quinones, but also contained phenolic, steroids, phenylpropanoids, fatty esters and other compounds [ 2 ]. In ethnomedicine, T. grandis is commonly used to treat wounds, pain, fever, malaria, inflammation, diabetes, liver disease, helminthic infection, bronchitis, tumors, cholelithiasis, jaundice, skin disease and bacterial infection [ 3 , 4 , 5 , 6 , 7 ]. Pharmacological studies conducted on the methanolic extracts of T. grandis bark and flowers established its hypoglycemic activities [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Anti-Diabetic Activities of Tectona grandis Methanolic Extracts, Fractions, and Isolated Compounds

et al. 2023

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Tectona grandis is a traditional Dai medicine plant belonging to the Lamiaceae family, which can be used to treat malaria, inflammation, diabetes, liver disease, bronchitis, tumors, cholelithiasis, jaundice, skin disease and as an anti-helminthic. To find more novel therapeutic agents contained in this medicinal plant, the antioxidant, anti-inflammatory and anti-diabetic activities of T. grandis methanolic extract, fractions and compounds were evaluated. In this study, 26 compounds were isolated from the leaves and branches of T. grandis. Their structures were identified based on extensive spectral experiments, including NMR, ESI-MS and comparison with published spectral data. Among them, compounds 1–2, 4–6, 9–14 and 16–22 were reported for the first time for this plant. The antioxidant activity screening results showed that compounds 5, 15 and 23 had potent antioxidant capacities, with SC50 values from 0.32 to 9.92 µmol/L, 0.92 to 1.10 mmol Trolox/L and 1.02 to 1.22 mmol Trolox/L for DPPH, ABTS and FRAP, respectively. In addition, their anti-inflammatory effects were investigated by releasing TNF-α, IL-1β and IL-6 through the use of mouse monocytic macrophages (RAW 264.7). Compounds 1, 13, 18 and 23 had the effects of reducing the expression of inflammatory factors. Compounds 13 and 18 were reported for the first time for their anti-inflammatory activities. Furthermore, the methanolic extract (ME), petroleum ether extract (PEE) and EtOAc extract (EAE) of T. grandis showed significant glucose uptake activities; compounds 21 and 23 significantly promoted glucose uptake of 3T3-L1 adipocytes at 40 µM. Meanwhile, compounds 4, 5 and 7 showed significant inhibitory activities against α-glucosidase, with IC50 values of 14.16 ± 0.34 µmol/L, 19.29 ± 0.26 µmol/L and 3.04 ± 0.08 µmol/L, respectively. Compounds 4 and 5 were reported for the first time for their α-glucosidase inhibitory activities. Our investigation explored the possible therapeutic material basis of T. grandis to prevent oxidative stress and related diseases, especially inflammation and diabetes.

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Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Anti-Diabetic Activities of Tectona grandis Methanolic Extracts, Fractions, and Isolated Compounds

et al. 2023

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“…It is known that effective control of the blood glucose level is a key step in preventing or reversing diabetic complications and improving the quality of life in diabetic patients [ 38 , 39 , 40 ]. The hypoglycemic activity of salidroside in alloxan-induced diabetic mice has been indicated here by estimation of fasting blood glucose levels, as the important basal parameter for monitoring of diabetes.…”

Section: Resultsmentioning

confidence: 99%

Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice

Tang

Xiao

et al. 2011

Molecules

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It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.

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“…The anti-hyperglycemic activity of Tectona grandis bark extract may be due to the regeneration of islets' β-cells following destruction by alloxan, as the extract shows significant reduction of blood glucose levels in 15 and 30 days, at a dosage of 2.5 and 5 g/kg body wt. 61 In a study, ethenolic extract of bark of Tectona grandis showed significant decrease in plasma glucose and serum triglyceride levels at the dose of 100 and 200 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscles.…”

Section: Tectona Grandis Linnmentioning

confidence: 99%

A Review on Antidiabetic Action of Asanadi Gana

Gupta¹,

Keshari²,

Tiwari³

et al. 2013

Int. J. Res. Ayurveda Pharm.

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Herbs and herbal drugs have created interest among the people due to their various clinically proven effects and lack of side effect. Moreover the overuse of synthetic drug which result in higher incidence of adverse drug reaction, has motivated the human to revert to nature for safer herbal medicines. The current review focuses on Asanadi gana (group of drugs) and its potential in the treatment of diabetes mellitus, a major crippling disease worldwide leading to huge economic loss. The review describes, various aspect of Asanadi gana like active phytoconstituents having hypoglycemic action, pharmacological properties and mechanism of action of its ingredients. This review also focuses on the traditional therapeutic action of the asanadi gana dravyas mentioned in ancient classics. In various pharmacological studies, done in last few decades on the drugs of asanadi gana dravyas, it has been proved that almost all the constituents of asanadi gana, posses anti hyperglycemic, hypolipidemic, antioxidant and other therapeutic properties

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Antihyperglycemic activity of Tectona grandis Linn. bark extract on alloxan induced diabetes in rats

Cited by 12 publications

References 11 publications

Antioxidant, Anti-Inflammatory and Anti-Diabetic Activities of Tectona grandis Methanolic Extracts, Fractions, and Isolated Compounds

Antioxidant, Anti-Inflammatory and Anti-Diabetic Activities of Tectona grandis Methanolic Extracts, Fractions, and Isolated Compounds

Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice

A Review on Antidiabetic Action of Asanadi Gana

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