Antihyperglycaemic, antihyperlipidaemic and β cell regenerative effects of Spondias pinnata (Linn. f.) Kurz. bark extract on streptozotocin induced diabetic rats

Biochemical and Histological Evaluation of Three Selected Medicinal Plant Extracts of Sri Lankan Origin on Dyslipidemia and Oxidative Stress in Alloxan Induced Diabetic Rats

“…However, the administration of the selected plant extracts significantly increased the concentrations of C-peptide and insulin indicating their potent antihyperglycemic activity in diabetic rats. The results are in accordance with our previously published data on investigation of detailed antidiabetic mechanisms of the selected extracts in streptozotocin induced diabetic rats [13,15,16,34,35]. In the present study, alloxan induced diabetic rats had an alteration in the lipid profile at the end of the study period.…”

“…Selection of the plant part was based on the use of the particular part in Ayurvedic preparations in the management of diabetes mellitus. Extensive research has been done for the investigation on phytochemicals, antidiabetic mechanisms, and in vitro antioxidant potentials of the selected plant extracts by our research group [12][13][14][15][16]. In addition, the optimum effective antihyperglycemic doses of the bark extracts of G. arborea and S. pinnata and leaf extract of C. grandis were found to be 1.00, 1.00, and 0.75 g/kg in alloxan induced diabetic rats, respectively [12].…”

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“…Kurz. bark extract in streptozotocin-induced diabetic rats was reported previously by our group (9). The isolation of 24-methylene cycloartanone, stigma4en-3one, lignoceric acid, β-sitosterol and its β-Dglucoside from S. pinnata have also described previously 10 .…”

Corrigendum to “Gmelina arborea Roxb. (Family: Verbenaceae) Extract Upregulates the β-Cell Regeneration in STZ Induced Diabetic Rats”

“…f.) Kurz. Bark Extract on Streptozotocin Induced Diabetic Rats” [2], as the two studies were conducted in parallel by the same group. The use of common animals in control groups reduced the number of animals used in the experiments, an important aspect of the 3Rs principle in ethics involving animal research [3].…”

“…The use of common animals in control groups reduced the number of animals used in the experiments, an important aspect of the 3Rs principle in ethics involving animal research [3]. Furthermore, a common methodology was followed in the two studies [1, 2]. …”