Antihyperglycaemic and tissue-repair effects of Myrmeleon formicarius extract in streptozotocin-induced diabetic mice

Prihatin, Jekti; Narulita, Erlia; Mufidah, Lailatul; Kurniawan, Alief; Wulandari, Dwi Tari; Hariyadi, Slamet

doi:10.1016/j.jtumed.2019.01.004

Cited by 6 publications

(7 citation statements)

References 20 publications

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“…It was previously demonstrated that there are pathological changes in hepatic tissue of STZ-induced T2DM mice, including focal necrosis, lymphocyte infiltration, obvious congestion in the central vein, and so on. 43,44 In this study, we observed histopathological changes in the liver and the results are presented in (Fig. 6A).…”

Section: Effect Of Lnt-1 On Histomorphological Changes Of Mouse Liver...mentioning

confidence: 57%

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway

Wang

Gong

et al. 2022

Food Funct.

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Section: Effect Of Lnt-1 On Histomorphological Changes Of Mouse Liver...mentioning

confidence: 57%

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway

Wang

Gong

et al. 2022

Food Funct.

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“…Based on a research by Prihatin Jekti, it can be known that the comparison between doses 2.5, 7.5 and 10 mg/kg are significant in lowering blood glucose level, but there was no significant differences between those doses. 10 From this study, it can be known that treatment group 1 (P1) is the group that had the most significant decrease of blood glucose level on the 28 th day seen from its p value <0.001, smaller than p value =0.0034 in treatment group 3 (P3). This result is in line with a research conducted by Tyas Kurniasih (2006) which showed that the administration of antions juice dosed 0.01 mg/200 g mice body weight can lower the blood glucose level in hyperglycemic mice (p<0.05).…”

Section: Discussionmentioning

confidence: 78%

The Effect of Antlions Extract Towards Blood Glucose Level of Male Swiss Mice Induced by Streptozotocin

Puspito

Jaeri

Widodo

et al. 2021

DMJ

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Background: Diabetes mellitus is a disease that is included in the group of metabolic diseases, characterized by hyperglycemia that occurs due to abnormal insulin secretion. Generally, treatment of diabetes mellitus uses insulin injection and Oral Hypoglycemic Drugs (OHD). In addition there are also animals are trusted by public in healing diabetes mellitus. Antlions (Myrmeleon sp) is a useful animal to treat diabetes mellitus. The body of antlions contains sulfonylureas which is a substance that stimulates insulin secretion in pancreatic beta cells. Aim: The objective of this research was to analyze the effect of antlions extract on blood glucose level of male swiss mice induced by streptozotocin Methods: This research was a pure experimental laboratory study and the design used is the Pre Test and Post Test Control Group Design, which is done by comparing the results of observations in the control and treatment groups after the action was done. Sampling was done using the simple random sampling technique. The sample size used in this study amounted to 30 mice. The data obtained were analyzed using ANOVA test with a confidence level of 95%. Results: The administration of antlions extract could lower (p<0.05) blood glucose levels in male Swiss mice after 28 days of treatment. The administration of antlions extract with doses of 14 mg/kgBW and 56 mg/kgBW significantly lowered blood glucose levels in male Swiss mice as evidenced by p=<0.001 and p=0.034. Whereas the administration of antlions extract with a dose of 28 mg/kgBW was less significant in lowering blood glucose levels in male Swiss mice (p=0.210). Conclusion: The administration of antlions extract (Myrmeleon sp.) with a dose of 14 mg/kgBW had the best effect on lowering blood glucose levels in male Swiss mice after 28 days of treatment. Keywords: diabetes mellitus, blood glucose, antlions

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“…The study showed that antlion extract treatment resulted in minimal damage in kidney and liver at 5 and 10 mg/ kg BW respectively. In the study, another compound present in antlion larvae extract is a chaperone protein that can stimulate cell regeneration (Prihatin et al, 2019). Heat Shock Protein (HSP) HSP70 is the most common HSP in humans that could inhibit TNF-αinduced free radical formation, lipid peroxidation, and apoptosis (Ikwegbue et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Heat Shock Protein (HSP) HSP70 is the most common HSP in humans that could inhibit TNF-αinduced free radical formation, lipid peroxidation, and apoptosis (Ikwegbue et al, 2018). Thus, chaperone protein present in antlion extract can also take effect in its tissue-repair ability (Kumar et al, 2014;Prihatin et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice

Widyatmaka

Ismail

2021

Sains Medika

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Introduction: Some studies indicated that antlions (Myrmeleon sp.) is traditionally used by many people in Indonesia as a diabetes treatmenter. However. reseach has not been done to find the effect of antlion extract in pancreas, an important organ in diabetes mellitus pathophysiology. Objective: To prove the effect of antlion extract towards histopathological feature of pancreas in diabetic mice.Methods: In the post test only control group design, 25 Swiss mice were divided into five groups. Normal group (Nor-G), Negative control group (Neg-G), and the other 3 groups were intraperitoneally injected with Streptozotocine 200 mg/kg to induce diabetic state. In Neg-G had no antlion treatment, whereas in At-14, At-28, and At-56 were treated with antlion extract at the dose of 14, 28, and 56 mg/kg BW respectively for 24 days. Pancreas then collected and prepared to be examined under microscope with 400x magnification. The score of pancreatic islet injury was determined by assessing structural damage and inflammatory cells infiltration. Kruskal-Wallis and Mann-Whitney were adopted as statistical analysis.Results: Mann-Whitney analysis indicated that the score of pancreatic islets injury in At-56 was significant lower compared to that of Neg-G, p<0.05. The score of pancreatic islets injury in At-56 also significant lower compared to that of At-14 and At-28, p<0.05. In contrary, when compared to that of Nor-G, the pancreatic islets injury in At-56 was not signicantly lower, p>0.05.Conclusion: Antlion extract treatment at the dose of 56 mg/kg BW was capable of reducing pancreatic islet injury in diabetic mice induced by streptozotocine.

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Antihyperglycaemic and tissue-repair effects of Myrmeleon formicarius extract in streptozotocin-induced diabetic mice

Cited by 6 publications

References 20 publications

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway

Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway

The Effect of Antlions Extract Towards Blood Glucose Level of Male Swiss Mice Induced by Streptozotocin

The Effect of Antlion (Myrmeleon sp.) Extract Towards Histopathology Image of Pancreas in Diabetic Mice

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