Antihyperglycaemic and protective effects of flavonoids on streptozotocin–induced diabetic rats

Abstract

The antihyperglycaemic effect of eight standard flavonoids, previously identified in the ethanol extract of the claimed antidiabetic plant Genista tenera, was evaluated on streptozotocin (STZ)‐induced diabetic Wistar rats. The aglycones apigenin, chrysoeriol and genistein, the monoglucosides apigenin 7‐O‐glucoside, luteolin 7‐O‐glucoside and genistein 7‐O‐glucoside and the diglycosides rutin and luteolin 7,3′‐di‐O‐glucoside were administered i.p. for 7 days (4 mg/kg b.w./day). The protective effect of these compounds over liver and kidneys of STZ–diabetic models was also evaluated by the determination of seric AST, ALT and urea levels. After 7 days of treatment, apigenin, chrysoeriol and genistein significantly lowered the blood glucose levels of diabetic animals; this effect was more pronounced (P < 0.01) in the oral glucose tolerance test. Glucose tolerance was also significantly improved in the rutin (P < 0.01) and in the genistein 7–O–glucoside (P < 0.05) treated groups. In addition, almost all the tested compounds effectively protected the liver and kidneys against STZ‐induced damage in rats. Copyright © 2010 John Wiley & Sons, Ltd.

Apigenin Causes Biochemical Modulation, Glut4 and Cd38 Alterations to Improve Diabetes and to Protect Damages of Some Vital Organs in Experimental Diabetes

“…The structural and biochemical functions of liver and kidneys may also be affected by alteration of insulin concentration which inhibits rapid glucose uptake and storage as glycogen in liver (Seyer et al, 2013). It is well recognized that flavonoids are able to improve diabetic subject by decreasing blood glucose levels (Rauter et al, 2010). In our study, a significant decrease of fasting blood glucose level upon apigenin administration in STZ-induced diabetic rats indicates the potential of the flavonoid to ameliorate DM.…”

Citrus medicaL. cv Diamante (Rutaceae) peel extract improves glycaemic status of Zucker diabetic fatty (ZDF) rats and protects against oxidative stress

“…Different works investigated the effect of these flavonoids on diabetes and metabolic syndrome. The antihyperglycaemic effect of apigenin was analysed on streptozotocin (STZ)-induced diabetic Wistar rats 24 . The administration of this flavonoid at the dose of 4 mg/kg bw/day after 1 week determined the reduction of blood GLU levels and demonstrated an efficient protection on liver and kidney.…”

Effects of Eclipta Alba and Diabetic Diet With Life Style Modifications on Blood Glucose Levels in Diabetic Patient

“…These phyto-chemicals are numerous but the important phytochemicals related to the present study are as Coumestans (wedelolactone & demethylwedelolactone) 10 , Terpenoids and their glycosides, Alkaloids 11 , Volatile oils, Saponins, Tannins, lignin 12 . Possible mechanisms for anti-hyperglycemic action of Eclipta alba based on previous studies are due to decrease intestinal absorption of glucose by α glucosidase inhibitory activity due to phytochemical, wedelolactone, demethylwedelolactone 13 , eclalbasaponin VI present in eclipta alba 14 ; Insulin secretagogue activity -volatile oil; Initiating release of insulin -tannin 15 ; Insulin sensitizing activity -saponin, tannin, lignin 15 ; Flavonoids suppress blood glucose level [16][17][18][19][20] .…”