Antihypercholesterolemic and antioxidant effect of sterol rich methanol extract of stem of Musa sapientum (banana) in cholesterol fed wistar rats

Abstract

Musa sapientum Linn. (English 'Banana' family Musaceae), is a plant with nutritive, as well as medicinal value. Antihypercholesterolemic and antioxidant effect of methanolic extract of stem of this plant was investigated in hypercholesterolemic rats. Rats were made hypercholesterolemic by feeding cholesterol (100 mg/kg/day) suspended in soya oil. Treatment groups received extract at a dose of 10, 20 and 40 mg/kg/day in addition to cholesterol orally once daily. Fasting blood samples were collected before and after 6 weeks treatment. Animals were sacrificed and liver stored at -80 °C. Total cholesterol, HDL-cholesterol and triacylglycerol were estimated in blood. Malondialdehyde, reduced glutathione, superoxide dismutase and catalase were measured in blood and liver. Total lipids, HMG CoA redutase and lipoprotein lipase were investigated in liver. Most effective dose was found to be 20 mg/kg/day. Rise in total cholesterol, LDL + VLDL-cholesterol and triacylglycerol in animals receiving only cholesterol was 179 %, 417 % and 74 % respectively, while in animals receiving 20 mg/kg dose rise in these parameters was restricted to 40 %, 106 % and 24 %. HDL-cholesterol decreased by 12 % in extract treated group, while it decreased to 36 % in untreated hypercholesterolemic rats. Malonaldialdehyde, marker of lipid peroxidation decreased while reduced glutathione and enzymes superoxide dismutase and catalase increased significantly in blood and liver (p < 0.01). Total lipids in liver decreased and enzymes of lipid metabolism viz. HMG CoA redutase and lipoprotein lipase were restored to near normal. Gas chromatography mass spectroscopy indicated high content of sterols in extract. Study demonstrated that methanol extract of stem of Musa sapientum has significant antihypercholesterolemic and antioxidant effects.

Naringenin attenuates highly active antiretroviral therapy‐induced sperm DNA fragmentations and testicular toxicity in Sprague‐Dawley rats

“…Thus, there may be need to include an adjuvant therapy with PrEP in the form of a phytochemical such as a flavonoid especially in those desirous of pregnancy to protect against the reproductive toxicity associated with the use of some ARTs. This can be either through the improvement in the oxidative status (Dikshit et al ., ; Kumar & Tiku, ) or through other pathways such as antihypercholesterolemic (Dikshit et al ., ), antiangiogenic, anti‐ischemic, inhibition of platelet aggregation, and anti‐inflammatory activities (Chu et al ., ).…”

“…Naringenin, the predominant flavanone in grapefruit, has been investigated for its beneficial properties. It is considered to have a bioactive effect on human health as an antioxidant (Dikshit et al ., ), free radical scavenger (Braca et al ., ), anti‐inflammatory (Bodet et al ., ), carbohydrate metabolism promoter (Kapoor et al ., ), immunity system modulator (Maatouk et al ., ), and repairs DNA (Gao et al ., ). Because of these promising properties and the fact that it has been shown to display antiretroviral effects especially as it demonstrated strong inhibition of virion assembly in the study by Khachatoorian et al .…”

Banana pseudostem substitution in wheat flour biscuits enriches the nutritional and antioxidative properties with considerable acceptability

“…ferulic acid, cinnamic acid, catechin, gingerol, with promising antioxidative activities has been reported [6]. It was shown that the methanolic extract of the pseudostem possesses significant hypolipidemic and antihypercholesterolemic properties [7]. Banana pseudostems also exhibited antimicrobial properties against both gram-positive and gram-negative bacteria and even antitumor activity against hepatocellular carcinoma (HepG-2) and human colon carcinoma (HCT-116) cell lines [8].…”

Antioxidant and antiproliferative activities on prostate and cervical cultured cancer cells of five medicinal plant extracts from Burkina Faso

“…A significant antidepressant-like activity was found in Musa sapientum stem extract in experimental models in mice (Reddy et al, 2016). Methanol extract of stems has significant antihypercholesterolemic and antioxidant effects (Dikshit et al, 2016). At last, Musa sapientum decoction extract of fresh unripe peels exhibited strong antioxidant activity (Phuaklee et al, 2012).…”