Antihistaminic properties of local anesthetics and anesthetic properties of antihistaminic compounds

Landau, Samuel; Nelson, William A.

doi:10.1016/0021-8707(51)90127-x

Cited by 36 publications

(2 citation statements)

References 13 publications

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“…Furthermore, the intracutaneous injec tion of a 0.05% solution of diphenhy dramine led to the complete absence of pain from pin pricks 5 min after injection [8]. In our investigation, the 2 different diphenhy dramine preparations were not able to pro duce any significant local anaesthesia even after a 1-hour pretreatment.…”

Section: Discussionmentioning

confidence: 54%

“…While some open studies suggested a benefit of these drugs against itching arising from insect bites, pruritus, urticaria and so on [1][2][3], others could not see effects differ ent from placebo [4][5][6]. Furthermore, a local anaesthetic effect of antihistamines has been demonstrated after intracutaneous injection of antihistamine solutions [7,8], For topical antihistaminics, controlled studies of anal gesia produced by ointments have not been published to our knowledge.…”

Section: Introductionmentioning

confidence: 99%

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Placebo-Controlled Study of the Efficacy of Topical Antihistaminics against Histamine-Induced Pruritus

E¹,

Rohdewald²

1985

Dermatology

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2 antipruritic ointments, when compared to placebo, were ineffective against histamine-induced itching applied in 2 volunteers after the intracutaneous injection of histamine. Testing of 11 topical antihistaminics after pretreatment for 30 and 60 min on 12 volunteers showed that some of the preparations reduced the histamine-induced itching significantly, while others were able to inhibit itching only slightly or were very close to placebo. Pain from pin pricks could not be attenuated significantly by pretreatment with the topical antihistaminics at any time.

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Section: Discussionmentioning

confidence: 54%