Diphenhydramine Hydrochloride as a Local Anesthetic Agent

Steffen, Charles; Zimmerman, Murray C.; Mihan, Richard

doi:10.1001/archderm.1956.01550070078015

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More Recent Local Anesthetics1

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Cited by 13 publications

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“…Lofgren and Lundqvist synthesized xylocaine in 1943 and Torsten Gordh introduced it clinically in 1949 17 . Steffen and colleagues reported on the use of antihistamines as local anesthetic agents in 1956 and 1957 and reviewed the literature on the subject 18, 19 . Tr ipelennamine (Pyribenzamine), pyrilamine maleate (Neo‐Antergan), diphenhydramine (Benadryl) and chlorprophenpyridamine maleate (Chlor‐Trimeton) each proved to be satisfactory anesthetic agents.…”

Section: More Recent Local Anestheticsmentioning

confidence: 99%