Antihistaminic Drugs in Dermatologic Therapy

Waldriff, George A.

doi:10.1001/archderm.1950.01530100005001

Cited by 9 publications

(1 citation statement)

References 16 publications

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“…The objection that all itching drug hypersensitivity reactions are not associated with a triple response can be met, as it seems that the release of sufficient histamine in the epidermis to cause severe itching may not be accompanied by a triple response, which is a dermal reaction. This view, which is in opposition to the contention of Rothman (1941) that itching without visible changes in the skin cannot be due to histamine, is strengthened by many reports that orally administered antihistamine drugs have some effect in relieving the pruritus of such conditions as eczema, prickly heat, chickenpox rashes, mosquito bites, the dermatitis of poison ivy, pruritus ani and vulvae (of uncertain aetiology), and pruritus associated with Hodgkin's disease, and obstructive jaundice (Baer and Sulzberger, 1946;Blumenthal and Rosenberg, 1947;Davis, 1950;Feinberg, 1950;Friedlaender and Feinberg, 1946;Gordon and Crewe, 1948;Hunter and Dunlop, 1948;Kuhn, 1949;Lynch, 1947;Silverman, 1949;Waldbott, 1946;and Waldriff, Davis, and Lewis, 1950). In many instances improvement in the pruritus leaves the rash unchanged.…”

Section: Discussionmentioning

confidence: 99%

Observations on Itching Produced by Cowhag, and on the Part Played by Histamine as a Mediator of the Itch Sensation

Broadbent

1953

British Journal of Pharmacology and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Observations on Itching Produced by Cowhag, and on the Part Played by Histamine as a Mediator of the Itch Sensation

Broadbent

1953

British Journal of Pharmacology and Chemotherapy

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Pharmacology and Toxicology

Leopold¹

1950

Arch Ophthalmol

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Appraisal of Topical Use of Antihistamines

Ellis¹,

Bundick²

1952

JAMA

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The era of antihistaminic therapy was instituted in 1933 when Fourneau and Bovet 1 demonstrated that certain phenolic ethers had the property of counteracting the action of histamine in vivo and in vitro. Their most effective compound, 929 F, as well as compound 1571 F, studied by Staub,2 were so toxic to humans as to preclude their therapeutic usage. In 1942 Halpern 3 reported his studies with compound 2339 RP (antergan\s=r\[dimethylamino-ethyl-benzylamine]), which proved to be well tolerated. Since then numerous antihistamines have been synthesized, studied, and made available for oral, parenteral, and topical use.The rapid succession of "new and better" antihistamines made appraisal of their value difficult and prompted a report by the Council on Pharmacy and Chemistry of the American Medical Association entitled "Too Many Drugs?" 4 Reports relating to the chemistry and pharmacology of the antihistamines and to the results of oral administration are plentiful and have been well summarized by Feinberg and others.5 We will con¬ fine this report to the clinical results obtained by the topi¬ cal application of the various antihistamines and will summarize herein the replies of 200 dermatologists to a questionnaire regarding their experiences with this type of therapy. PREVIOUS STUDIES Ethylenediamine Derivatives.1*-Tripelennamine (py-ribenzamine® [Ciba] ) hydrochloride: Feinberg and Bern¬ stein 7 found that the topical application of 2% tripelen¬ namine hydrochloride in water soluble or anhydrous base ointments afforded relief of itching in 24 of 33 pa¬ tients with atopic dermatitis and in 8 of 9 patients with .pruritus ani. Sulzberger and co-workers8 treated 90 pa¬ tients with tripelennamine cream. Allergic, contact-type, eczematous sensitization confirmed by patch test oc¬ curred in two of them. Sulzberger and co-authors con¬ cluded that 2 to 5 % tripelennamine hydrochloride cream was a good, clean, nonstaining ointment useful in the treatment of lichen simplex chronicus. They were unable to confirm Feinberg's 7 beneficial results in atopic der¬ matitis and pruritus ani. Waldriff and associates 9 in¬ cluded 141 patients treated with tripelennamine topically in their series. Thirty-three of these received good to excellent results, and 50 fair results. It appeared to be most useful in circumscribed neurodermatitis, for which 23 of 29 patients attained at least fair results. In the total series (141 patients) there were 10 reactions.Thenylpyramine ("histadyl" [Lilly]) hydrochloride or methapyrilene (thenylene® [Abbott]) hydrochloride: Bereston 10 used thenylpyramine hydrochloride cream and reported temporary relief of pruritus in 40% of 104 patients with dermatoses in which the cardinal symptom was pruritus, but few permanent or lasting results were observed. No cases of contact dermatitis were seen. Ep¬ stein and Macaulay11 stated that 2% thenylpyramine hydrochloride cream was a valuable adjunct to topical therapy of various forms of allergic dermatoses, especially lichen simplex chronicus. Occasionally the ointm...

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Antihistaminic Drugs in Dermatologic Therapy

Cited by 9 publications

References 16 publications

Observations on Itching Produced by Cowhag, and on the Part Played by Histamine as a Mediator of the Itch Sensation

Observations on Itching Produced by Cowhag, and on the Part Played by Histamine as a Mediator of the Itch Sensation

Pharmacology and Toxicology

Appraisal of Topical Use of Antihistamines

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