Abstract:The era of antihistaminic therapy was instituted in 1933 when Fourneau and Bovet 1 demonstrated that certain phenolic ethers had the property of counteracting the action of histamine in vivo and in vitro. Their most effective compound, 929 F, as well as compound 1571 F, studied by Staub,2 were so toxic to humans as to preclude their therapeutic usage. In 1942 Halpern 3 reported his studies with compound 2339 RP (antergan\s=r\[dimethylamino-ethyl-benzylamine]), which proved to be well tolerated. Since then nume… Show more
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