Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

“…18) Andrographolide played a hepatoprotective role by reducing a lipid peroxidation product malondialdehyde (MDA), in which the lowering of MDA formation conveyed the free radical scavenging property of diterpene lactones of andrographolide, as well as by maintaining high level of glutathione, glutamicpyruvate transaminase, and alkaline phosphatase in carbontetrachloride or tert-butylhydroperoxide treated mice. 19) Antihepatotoxic action of andrographolide against Plasmodium berghei K173-induced hepatic damage of Mastomys natalensis was noted. 20) In other studies, andrographolide was sug-gested to play a role as a potent stimulator of gallbladder function by producing a significant increase in bile flow, bile salts, and bile acid in conscious rats and anaesthetized guinea pigs.…”

“…5) In Thailand, this plant was selected by the Ministry of Public Health as one of the medicinal plants to be included in "The National List of Essential Drugs A.D. 1999" (List of Herbal Medicinal Products). 6) Extensive research has revealed that Andrographis paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial, such as antiinflammatory, [7][8][9][10][11] antidiarrhoeal, 12,13) antiviral, 14) anti-malarial, 15,16) hepatoprotective, [17][18][19][20][21][22][23][24][25][26][27][28][29] cardiovascular, 30,31) anticancer, [32][33][34][35][36][37][38][39] and immunostimulatory [40][41][42][43][44] activities. On the other hand, male reproductive toxicity 45) and cytotoxicity 46) of this plant have been reported as well.…”

Effects of <i>Moringa</i> based Feed Additives on the Growth Performance and Carcass Quality of Broiler Chicken

“…The four herbal plant parts Andrographis paniculata, Solanum nigrum, Phylanthus niruni and Boerhavia diffusa are used in the preparation of Zigbir  . It has been shown that these herbs have beneficial effect on liver health and productivity of animals (Kapil et al, 1993). Therefore, objective of the present study was to evaluate the beneficial effects of selected herbal feed additives on the growth performance and carcass quality of broiler chicken.…”

Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

“…Piperine has been shown to exert a significant protection against liver toxicity induced by tert-butyl hydroperoxide and carbon tetrachloride by reducing both invitro and invivo lipid peroxidation by decreasing the reduction of GSH. [22,23] …”