Antihepatotoxic Effects of chlorogenic acid from Anthocephalus cadamba

Abstract

In the present study, chlorogenic acid (CGA) isolated from Anfhocephalus cadamba was screened for hepatoprotective activity by in uifro and in uiuo assay methods using carbon tetrachloride (CCI,) as a model of liver iqjury. Intraperitoneal administration of CGA to mice at a dose of 100 mgkg body weight for 8 days caused significant reversal in lipid peroxidation, enzymatic leakage, cytochrome P450 (Cyt P450) inactivation and produced enhancement of cellular antioxidant defence in CC4-intoxicated mice, revealii that the antioxidative action of CGA is responsible for its liver protective activity. CGA exhibited a better therapeutic protective action than silymarin (SM), in CCl.,-administered mice.

Hepatoprotection by chemical constituents of the marine brown algaSpatoglossum variabile: A relation to free radical scavenging potential

“…Hepatoprotective studies were performed by the method of Kapil with slight modifications (Kapil et al, 1995). Wistar rats were divided into seven groups of six animals.…”

3-Hydroxy-6-Methylpyridine with Preventive Activity on Carbon Tetrachloride-Induced Liver Injury Is Produced During Roasting of Coffee Beans

“…These amounts were much higher than those of 3,6-Py in the same coffee samples. Therefore, the stronger suppressive effects of coffee against liver injury from the light-roasted beans, compared to that from the French-roasted beans, might be mainly due to the higher content of chlorogenic acid in the light-roasted coffee, as chlorogenic acid is known to be available for the prevention of liver injury (Kapil et al, 1995;Zhou et al, 1993). The DPPH radical scavenging activity of chlorogenic acid (1.14 µmol TE/µmol sample) was stronger than that of 3-Py (9.09 × 10 -3 ) and 3,6-Py (9.07 × 10 -3 µmol TE/µmol sample) when measured using the DPPH method (Takahata et al, 2001).…”

“…On the other hand, coffee has been found to suppress the occurrence of stomach and liver cancers (Bauer et al, 1977;Mohr et al, 1984;Inoue et al, 2005). Instant coffee, and coffee diterpenes, kahweol and cafestrol, and chlorogenic acid are reported to prevent acute liver injury induced by carbon tetrachloride (CCl 4 ) (Ozercan et al, 2006;Lee et al, 2007;Kapil et al, 1995;Zhou et al, 1993). Moreover, coffee has been reported to be effective in the prevention of liver injury and the mitigation of type 2 diabetes (Dam and Feskens, 2002), although the validity of these findings is still under debate (Ruhl and Everhart, 2005;Haner et al, 2008).…”

Antinociceptive and gastro-protective effect of the ethanolic extract of the flowering top of Anthocephalus Cadamba Roxb

“…The leaves are recommended as a gargle in cases of stomatitis (Slkar et al, 1996). Some scientific studies have been carried out to reveal its antimalarial (Sianne and Fanie, 2002) and antihepatotoxic activities (Kapil et al, 1995). A. Cadamba is ethnomedicinally widely used in the form of paste by tribe in Western Ghats for treating skin diseases.…”